ENSG00000163281

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295448 ENSG00000163281 HEK293_OSMI2_2hA HEK293_TMG_2hB GNPDA2 protein_coding protein_coding 3.714747 1.21795 5.089044 0.1657867 0.06861262 2.053975 1.3840245 0.63563255 2.06855120 0.07400022 0.17266602 1.686793 0.42128333 0.53060000 0.40630000 -0.1243000000 0.399345264 0.005495509 FALSE TRUE
ENST00000507534 ENSG00000163281 HEK293_OSMI2_2hA HEK293_TMG_2hB GNPDA2 protein_coding protein_coding 3.714747 1.21795 5.089044 0.1657867 0.06861262 2.053975 0.9736271 0.06723188 1.27441180 0.03370736 0.17253074 4.055768 0.18347500 0.04953333 0.25123333 0.2017000000 0.005495509 0.005495509 FALSE TRUE
ENST00000507917 ENSG00000163281 HEK293_OSMI2_2hA HEK293_TMG_2hB GNPDA2 protein_coding protein_coding 3.714747 1.21795 5.089044 0.1657867 0.06861262 2.053975 0.0291185 0.11412799 0.00000000 0.11412799 0.00000000 -3.633757 0.03859583 0.07703333 0.00000000 -0.0770333333 0.423041041 0.005495509 FALSE TRUE
ENST00000509756 ENSG00000163281 HEK293_OSMI2_2hA HEK293_TMG_2hB GNPDA2 protein_coding protein_coding 3.714747 1.21795 5.089044 0.1657867 0.06861262 2.053975 0.7543827 0.20653236 1.24760138 0.01175539 0.10048949 2.538020 0.19060417 0.17953333 0.24523333 0.0657000000 0.392814768 0.005495509 FALSE TRUE
ENST00000609092 ENSG00000163281 HEK293_OSMI2_2hA HEK293_TMG_2hB GNPDA2 protein_coding protein_coding 3.714747 1.21795 5.089044 0.1657867 0.06861262 2.053975 0.2103358 0.08428907 0.33127495 0.04638330 0.18280352 1.855772 0.05892917 0.06320000 0.06413333 0.0009333333 0.949513972 0.005495509 FALSE TRUE
MSTRG.24821.3 ENSG00000163281 HEK293_OSMI2_2hA HEK293_TMG_2hB GNPDA2 protein_coding   3.714747 1.21795 5.089044 0.1657867 0.06861262 2.053975 0.2255710 0.10098986 0.05546383 0.05242309 0.01215247 -0.761658 0.06493750 0.09290000 0.01090000 -0.0820000000 0.116159096 0.005495509 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163281 E001 0.0000000       4 44682200 44682207 8 -      
ENSG00000163281 E002 0.1515154 0.0418332200 1.000000000   4 44682208 44682384 177 - 0.070 0.000 -8.237
ENSG00000163281 E003 0.1515154 0.0418332200 1.000000000   4 44682385 44682581 197 - 0.070 0.000 -8.236
ENSG00000163281 E004 0.9233738 0.0145018989 0.570328634 0.696830471 4 44682582 44682642 61 - 0.231 0.344 0.787
ENSG00000163281 E005 0.2987644 0.0293417708 0.850923761   4 44701795 44701867 73 - 0.130 0.000 -9.236
ENSG00000163281 E006 31.6992963 0.0273395129 0.006853320 0.020844493 4 44701868 44702787 920 - 1.373 1.655 0.966
ENSG00000163281 E007 22.2000403 0.0008975551 0.790306390 0.865843000 4 44702788 44703142 355 - 1.299 1.334 0.121
ENSG00000163281 E008 0.9567573 0.4122297946 0.228444889 0.360564521 4 44703143 44703245 103 - 0.130 0.468 2.472
ENSG00000163281 E009 43.9191300 0.0007144416 0.349123598 0.493353262 4 44703246 44705491 2246 - 1.577 1.643 0.224
ENSG00000163281 E010 14.6747182 0.0013412837 0.042103367 0.094913688 4 44705492 44706411 920 - 1.181 0.976 -0.744
ENSG00000163281 E011 27.4371009 0.0082125669 0.001241211 0.004780799 4 44706412 44707751 1340 - 1.457 1.173 -0.991
ENSG00000163281 E012 37.2107260 0.0006054575 0.331303880 0.474902402 4 44707752 44707926 175 - 1.542 1.495 -0.161
ENSG00000163281 E013 34.3131288 0.0055615102 0.378801343 0.523094257 4 44710953 44711137 185 - 1.508 1.458 -0.169
ENSG00000163281 E014 29.4842307 0.0010822698 0.598782591 0.720311686 4 44717113 44717295 183 - 1.419 1.469 0.172
ENSG00000163281 E015 20.7815783 0.0009586788 0.547524813 0.677575746 4 44718309 44718410 102 - 1.291 1.254 -0.132
ENSG00000163281 E016 25.7404975 0.0036967579 0.831330066 0.894277432 4 44722084 44722242 159 - 1.363 1.391 0.098
ENSG00000163281 E017 16.8557367 0.0053635960 0.991240215 0.998644160 4 44726474 44726700 227 - 1.196 1.207 0.040