ENSG00000163170

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295326 ENSG00000163170 HEK293_OSMI2_2hA HEK293_TMG_2hB BOLA3 protein_coding protein_coding 119.574 171.0432 121.892 15.31959 6.811634 -0.488723 62.68668 94.08168 54.8503 5.968592 3.925493 -0.7783048 0.5308125 0.5525333 0.4492667 -0.1032667 0.0006095677 0.0006095677 FALSE FALSE
ENST00000327428 ENSG00000163170 HEK293_OSMI2_2hA HEK293_TMG_2hB BOLA3 protein_coding protein_coding 119.574 171.0432 121.892 15.31959 6.811634 -0.488723 56.73286 76.83276 66.9435 9.417856 2.952437 -0.1987499 0.4676708 0.4467333 0.5499333 0.1032000 0.0006853927 0.0006095677 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163170 E001 1.508113 0.010325719 0.282507524 0.422519111 2 74135400 74135400 1 - 0.256 0.455 1.205
ENSG00000163170 E002 5.113458 0.003900503 0.002776592 0.009603233 2 74135401 74135414 14 - 0.415 0.881 2.044
ENSG00000163170 E003 789.822756 0.001585069 0.010849456 0.030804075 2 74135415 74135658 244 - 2.849 2.899 0.165
ENSG00000163170 E004 485.458744 0.000978433 0.005496464 0.017277636 2 74142272 74142360 89 - 2.703 2.656 -0.158
ENSG00000163170 E005 943.690560 0.000166847 0.391377518 0.535287129 2 74145189 74145303 115 - 2.962 2.959 -0.010
ENSG00000163170 E006 2.294835 0.006846787 0.425816365 0.568704761 2 74145304 74146241 938 - 0.580 0.455 -0.601
ENSG00000163170 E007 3.397606 0.005183398 0.184348370 0.306681236 2 74146242 74147226 985 - 0.478 0.696 0.984
ENSG00000163170 E008 1.663781 0.008818749 0.548229186 0.678094699 2 74147227 74147820 594 - 0.343 0.455 0.621
ENSG00000163170 E009 573.458414 0.002128889 0.715492950 0.811382830 2 74147821 74147912 92 - 2.747 2.738 -0.030