ENSG00000163166

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295321 ENSG00000163166 HEK293_OSMI2_2hA HEK293_TMG_2hB IWS1 protein_coding protein_coding 28.46431 22.44638 36.93761 1.173866 0.9228304 0.7183557 21.933587 15.097007 31.3622285 0.7428253 0.7051093 1.054270 0.75046667 0.6729000 0.84936667 0.17646667 1.060540e-08 1.06054e-08 FALSE TRUE
MSTRG.19171.5 ENSG00000163166 HEK293_OSMI2_2hA HEK293_TMG_2hB IWS1 protein_coding   28.46431 22.44638 36.93761 1.173866 0.9228304 0.7183557 1.548070 2.918401 0.4321784 0.2795510 0.4321784 -2.727413 0.06267500 0.1298333 0.01196667 -0.11786667 3.782314e-02 1.06054e-08 FALSE TRUE
MSTRG.19171.8 ENSG00000163166 HEK293_OSMI2_2hA HEK293_TMG_2hB IWS1 protein_coding   28.46431 22.44638 36.93761 1.173866 0.9228304 0.7183557 1.925554 2.333774 1.1065611 0.1441150 0.3270445 -1.069772 0.07762083 0.1039333 0.03020000 -0.07373333 9.209674e-04 1.06054e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163166 E001 0.0000000       2 127436207 127436297 91 -      
ENSG00000163166 E002 0.9577023 0.0174959176 6.443125e-01 7.566378e-01 2 127469986 127470134 149 - 0.253 0.343 0.607
ENSG00000163166 E003 0.4427912 0.2349085432 8.479504e-01 9.055796e-01 2 127470251 127470385 135 - 0.184 0.145 -0.409
ENSG00000163166 E004 0.5858876 0.0205930443 5.242387e-01 6.578380e-01 2 127480810 127480811 2 - 0.253 0.147 -0.978
ENSG00000163166 E005 2.6914276 0.0569584987 2.072157e-01 3.351896e-01 2 127480812 127480813 2 - 0.454 0.696 1.106
ENSG00000163166 E006 12.6063462 0.0015085611 3.471423e-07 3.170471e-06 2 127480814 127480831 18 - 0.832 1.340 1.849
ENSG00000163166 E007 19.7516761 0.0009973177 3.151400e-04 1.441493e-03 2 127480832 127480835 4 - 1.160 1.452 1.024
ENSG00000163166 E008 27.4454839 0.0014970226 3.389021e-06 2.507772e-05 2 127480836 127480854 19 - 1.271 1.602 1.143
ENSG00000163166 E009 323.4472286 0.0022598462 3.893680e-15 1.361975e-13 2 127480855 127481175 321 - 2.379 2.627 0.828
ENSG00000163166 E010 2.9915295 0.0049308672 2.132468e-02 5.426906e-02 2 127485874 127486033 160 - 0.717 0.344 -1.806
ENSG00000163166 E011 267.6342244 0.0034314053 6.841161e-08 7.174301e-07 2 127486553 127486664 112 - 2.321 2.528 0.690
ENSG00000163166 E012 209.9942837 0.0020860098 8.057400e-07 6.826701e-06 2 127489179 127489235 57 - 2.233 2.410 0.591
ENSG00000163166 E013 3.7923292 0.0043451316 7.703433e-01 8.516756e-01 2 127489818 127489831 14 - 0.695 0.664 -0.129
ENSG00000163166 E014 276.7356410 0.0035108949 1.647130e-05 1.041430e-04 2 127489832 127489943 112 - 2.356 2.526 0.568
ENSG00000163166 E015 267.8424232 0.0025108351 3.249168e-04 1.480601e-03 2 127491971 127492088 118 - 2.360 2.493 0.442
ENSG00000163166 E016 241.5600087 0.0014305412 3.197533e-05 1.889584e-04 2 127493281 127493410 130 - 2.313 2.449 0.454
ENSG00000163166 E017 180.3451212 0.0025268959 5.139359e-03 1.630745e-02 2 127494872 127494954 83 - 2.197 2.314 0.390
ENSG00000163166 E018 230.2766026 0.0019220685 8.034658e-03 2.386775e-02 2 127495998 127496148 151 - 2.311 2.411 0.331
ENSG00000163166 E019 188.3826829 0.0009343020 6.177783e-01 7.355126e-01 2 127498140 127498237 98 - 2.258 2.289 0.102
ENSG00000163166 E020 2.8628307 0.0152507623 5.175002e-03 1.640379e-02 2 127502579 127502814 236 - 0.739 0.256 -2.478
ENSG00000163166 E021 177.8690159 0.0002074362 9.177612e-01 9.520081e-01 2 127502815 127502872 58 - 2.239 2.257 0.060
ENSG00000163166 E022 302.6717313 0.0015097150 2.233005e-01 3.543284e-01 2 127503387 127503573 187 - 2.456 2.505 0.162
ENSG00000163166 E023 106.7740622 0.0054980379 6.532260e-02 1.355767e-01 2 127503574 127503576 3 - 1.980 2.085 0.352
ENSG00000163166 E024 381.8653290 0.0014854131 9.631303e-01 9.807156e-01 2 127504684 127504997 314 - 2.572 2.587 0.049
ENSG00000163166 E025 142.2765401 0.0002713893 2.478196e-03 8.698709e-03 2 127504998 127505039 42 - 2.181 2.103 -0.260
ENSG00000163166 E026 114.6517209 0.0004372769 7.628900e-06 5.205937e-05 2 127505040 127505054 15 - 2.115 1.974 -0.473
ENSG00000163166 E027 171.2831537 0.0002519925 7.848278e-06 5.341018e-05 2 127505055 127505125 71 - 2.277 2.167 -0.369
ENSG00000163166 E028 95.5859668 0.0003290171 1.005370e-04 5.243773e-04 2 127505126 127505132 7 - 2.034 1.904 -0.438
ENSG00000163166 E029 145.3257503 0.0002689687 7.560285e-04 3.100964e-03 2 127505133 127505190 58 - 2.198 2.111 -0.291
ENSG00000163166 E030 112.9557147 0.0009891184 5.185339e-07 4.572634e-06 2 127505191 127505210 20 - 2.122 1.951 -0.573
ENSG00000163166 E031 115.2117649 0.0082064587 3.328939e-03 1.123198e-02 2 127505211 127505241 31 - 2.118 1.973 -0.487
ENSG00000163166 E032 135.4273081 0.0069649972 3.676069e-03 1.222863e-02 2 127505242 127505306 65 - 2.187 2.052 -0.450
ENSG00000163166 E033 91.7444510 0.0004653576 1.095595e-09 1.612596e-08 2 127505307 127505320 14 - 2.050 1.825 -0.755
ENSG00000163166 E034 83.4309944 0.0009705211 1.793348e-09 2.535217e-08 2 127505321 127505327 7 - 2.015 1.773 -0.815
ENSG00000163166 E035 98.0070660 0.0018599855 1.558233e-05 9.905792e-05 2 127505328 127505349 22 - 2.059 1.893 -0.558
ENSG00000163166 E036 95.7941779 0.0014185830 5.292957e-04 2.269093e-03 2 127505350 127505387 38 - 2.031 1.905 -0.425
ENSG00000163166 E037 193.6195684 0.0025347113 1.526403e-05 9.725315e-05 2 127505388 127505554 167 - 2.339 2.202 -0.459
ENSG00000163166 E038 220.4197758 0.0013665924 1.573831e-10 2.684411e-09 2 127505555 127505752 198 - 2.411 2.234 -0.591
ENSG00000163166 E039 0.0000000       2 127506692 127506719 28 -      
ENSG00000163166 E040 0.2214452 0.0378762911 3.367956e-01   2 127514817 127514937 121 - 0.000 0.147 9.167
ENSG00000163166 E041 150.7138148 0.0009230875 8.680833e-08 8.918524e-07 2 127523676 127523791 116 - 2.240 2.081 -0.534
ENSG00000163166 E042 129.6930307 0.0057240233 1.872451e-03 6.830415e-03 2 127526175 127526382 208 - 2.165 2.030 -0.450
ENSG00000163166 E043 56.2430810 0.0059842316 1.447347e-01 2.544703e-01 2 127526383 127526410 28 - 1.781 1.709 -0.243
ENSG00000163166 E044 50.5507482 0.0030454256 9.076866e-02 1.763514e-01 2 127526411 127526489 79 - 1.736 1.657 -0.270
ENSG00000163166 E045 10.0020739 0.0018094465 1.072204e-03 4.208466e-03 2 127526636 127526886 251 - 1.167 0.821 -1.286