ENSG00000163138

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360916 ENSG00000163138 HEK293_OSMI2_2hA HEK293_TMG_2hB PACRGL protein_coding protein_coding 8.882041 3.926535 13.44544 0.3760819 0.467696 1.773192 0.2998484 0.02299563 0.8167338 0.02299563 0.15537695 4.64707597 0.02418750 0.00490000 0.06070000 0.05580000 0.004922135 0.004922135 FALSE  
ENST00000467997 ENSG00000163138 HEK293_OSMI2_2hA HEK293_TMG_2hB PACRGL protein_coding nonsense_mediated_decay 8.882041 3.926535 13.44544 0.3760819 0.467696 1.773192 1.2211711 0.91998134 1.8909139 0.17756410 0.07214716 1.03141951 0.17090833 0.23630000 0.14130000 -0.09500000 0.211937626 0.004922135 TRUE  
ENST00000503747 ENSG00000163138 HEK293_OSMI2_2hA HEK293_TMG_2hB PACRGL protein_coding nonsense_mediated_decay 8.882041 3.926535 13.44544 0.3760819 0.467696 1.773192 0.9984679 0.12525744 0.6331149 0.12525744 0.36981484 2.24936853 0.08978750 0.03523333 0.04540000 0.01016667 0.778534782 0.004922135    
ENST00000506702 ENSG00000163138 HEK293_OSMI2_2hA HEK293_TMG_2hB PACRGL protein_coding nonsense_mediated_decay 8.882041 3.926535 13.44544 0.3760819 0.467696 1.773192 0.2740685 0.37833123 0.3723095 0.20163900 0.18552433 -0.02254673 0.03618333 0.09103333 0.02686667 -0.06416667 0.612056945 0.004922135 TRUE  
ENST00000513861 ENSG00000163138 HEK293_OSMI2_2hA HEK293_TMG_2hB PACRGL protein_coding protein_coding 8.882041 3.926535 13.44544 0.3760819 0.467696 1.773192 0.6635130 0.16954508 1.8125730 0.16954508 0.29214755 3.34355853 0.06299167 0.04770000 0.13530000 0.08760000 0.225198105 0.004922135 FALSE  
MSTRG.24689.27 ENSG00000163138 HEK293_OSMI2_2hA HEK293_TMG_2hB PACRGL protein_coding   8.882041 3.926535 13.44544 0.3760819 0.467696 1.773192 1.3156232 0.59157303 2.3615338 0.32712453 0.39093283 1.97900864 0.13508750 0.14096667 0.17650000 0.03553333 0.806532662 0.004922135 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163138 E001 0.0000000       4 20696282 20696513 232 +      
ENSG00000163138 E002 0.0000000       4 20700413 20700418 6 +      
ENSG00000163138 E003 0.0000000       4 20700419 20700426 8 +      
ENSG00000163138 E004 0.2966881 0.0270346731 0.64400502   4 20700427 20700435 9 + 0.150 0.000 -11.204
ENSG00000163138 E005 0.5933762 0.0221310715 0.23339205 0.36643122 4 20700436 20700437 2 + 0.261 0.000 -14.232
ENSG00000163138 E006 0.5933762 0.0221310715 0.23339205 0.36643122 4 20700438 20700438 1 + 0.261 0.000 -14.232
ENSG00000163138 E007 1.0373134 0.0118412466 0.06551660 0.13590045 4 20700439 20700454 16 + 0.388 0.000 -14.973
ENSG00000163138 E008 1.0373134 0.0118412466 0.06551660 0.13590045 4 20700455 20700457 3 + 0.388 0.000 -14.973
ENSG00000163138 E009 1.0373134 0.0118412466 0.06551660 0.13590045 4 20700458 20700458 1 + 0.388 0.000 -14.973
ENSG00000163138 E010 1.0373134 0.0118412466 0.06551660 0.13590045 4 20700459 20700459 1 + 0.388 0.000 -14.973
ENSG00000163138 E011 1.0373134 0.0118412466 0.06551660 0.13590045 4 20700460 20700465 6 + 0.388 0.000 -14.973
ENSG00000163138 E012 1.1824861 0.0115372739 0.04446816 0.09923387 4 20700466 20700468 3 + 0.424 0.000 -15.131
ENSG00000163138 E013 3.2076907 0.0050628519 0.33093699 0.47450613 4 20700469 20700471 3 + 0.654 0.485 -0.775
ENSG00000163138 E014 3.6516279 0.0044281082 0.18557208 0.30821628 4 20700472 20700472 1 + 0.710 0.485 -1.009
ENSG00000163138 E015 9.1859557 0.0144240890 0.33410785 0.47785509 4 20700473 20700475 3 + 1.021 0.885 -0.510
ENSG00000163138 E016 10.8800274 0.0092209559 0.92287804 0.95536061 4 20700476 20700476 1 + 1.054 1.032 -0.082
ENSG00000163138 E017 11.7271141 0.0143457779 0.92536747 0.95701593 4 20700477 20700480 4 + 1.077 1.072 -0.020
ENSG00000163138 E018 24.7329062 0.0008524394 0.39908885 0.54282868 4 20700481 20700578 98 + 1.371 1.425 0.188
ENSG00000163138 E019 19.1103375 0.0017510373 0.15128640 0.26342606 4 20700579 20700611 33 + 1.243 1.353 0.382
ENSG00000163138 E020 14.4945389 0.0208870464 0.18413389 0.30641053 4 20700612 20700617 6 + 1.120 1.251 0.466
ENSG00000163138 E021 22.4432548 0.0041356131 0.70676984 0.80486800 4 20700618 20700670 53 + 1.340 1.362 0.078
ENSG00000163138 E022 24.3837559 0.0015224915 0.92667856 0.95783329 4 20700671 20700706 36 + 1.386 1.372 -0.049
ENSG00000163138 E023 26.0079879 0.0008132767 0.77201824 0.85286874 4 20700707 20700747 41 + 1.418 1.391 -0.095
ENSG00000163138 E024 23.6199367 0.0008847362 0.87550408 0.92403632 4 20700748 20700787 40 + 1.367 1.372 0.017
ENSG00000163138 E025 0.0000000       4 20701510 20701518 9 +      
ENSG00000163138 E026 1.0317993 0.2104189788 0.59488846 0.71704891 4 20701519 20701667 149 + 0.261 0.397 0.856
ENSG00000163138 E027 0.3268771 0.0330606418 0.48695078   4 20701726 20701757 32 + 0.081 0.180 1.314
ENSG00000163138 E028 5.6964123 0.0101542832 0.61380529 0.73243496 4 20701758 20701884 127 + 0.831 0.749 -0.324
ENSG00000163138 E029 5.5349958 0.0100577631 0.24647480 0.38182623 4 20702141 20702221 81 + 0.844 0.662 -0.738
ENSG00000163138 E030 0.0000000       4 20702651 20702674 24 +      
ENSG00000163138 E031 0.1451727 0.0436849862 1.00000000   4 20702675 20702740 66 + 0.081 0.000 -12.262
ENSG00000163138 E032 47.5050522 0.0005544614 0.75002278 0.83680230 4 20704466 20704533 68 + 1.663 1.673 0.035
ENSG00000163138 E033 71.9108656 0.0003985551 0.54726498 0.67734047 4 20704660 20704814 155 + 1.834 1.853 0.061
ENSG00000163138 E034 0.2924217 0.0272508889 0.64390117   4 20707802 20707802 1 + 0.150 0.000 -13.299
ENSG00000163138 E035 35.6519082 0.0104936224 0.86844829 0.91943157 4 20707803 20707870 68 + 1.552 1.520 -0.109
ENSG00000163138 E036 34.3471692 0.0203522167 0.71615615 0.81187734 4 20709683 20709773 91 + 1.544 1.489 -0.187
ENSG00000163138 E037 0.2924217 0.0272508889 0.64390117   4 20709774 20709836 63 + 0.150 0.000 -13.299
ENSG00000163138 E038 1.0748892 0.0243860769 0.98947366 0.99744492 4 20712699 20712787 89 + 0.308 0.306 -0.011
ENSG00000163138 E039 50.8874935 0.0090387924 0.52100383 0.65490234 4 20712788 20712922 135 + 1.712 1.659 -0.181
ENSG00000163138 E040 0.8168978 0.0151684745 0.69466650 0.79544071 4 20713076 20713431 356 + 0.261 0.180 -0.686
ENSG00000163138 E041 48.4834933 0.0004920119 0.34658072 0.49070054 4 20713432 20713539 108 + 1.659 1.701 0.142
ENSG00000163138 E042 0.1472490 0.0447337650 1.00000000   4 20713540 20713541 2 + 0.082 0.000 -12.256
ENSG00000163138 E043 0.7415557 0.1192119779 0.70699406 0.80502656 4 20716107 20716248 142 + 0.262 0.179 -0.697
ENSG00000163138 E044 1.8831524 0.0076210344 0.33313853 0.47681791 4 20718816 20718976 161 + 0.388 0.552 0.827
ENSG00000163138 E045 17.5050493 0.0076985689 0.68081833 0.78466783 4 20724808 20724888 81 + 1.259 1.213 -0.159
ENSG00000163138 E046 0.0000000       4 20724889 20724889 1 +      
ENSG00000163138 E047 51.7777005 0.0056196526 0.39124548 0.53517608 4 20727285 20727397 113 + 1.686 1.738 0.179
ENSG00000163138 E048 138.5245270 0.0003622849 0.41788694 0.56120046 4 20727398 20732557 5160 + 2.134 2.104 -0.102
ENSG00000163138 E049 13.8980687 0.0089961037 0.10759043 0.20198074 4 20752565 20752907 343 + 1.099 1.252 0.543