ENSG00000163125

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369068 ENSG00000163125 HEK293_OSMI2_2hA HEK293_TMG_2hB RPRD2 protein_coding protein_coding 14.17196 12.09643 15.26835 0.5387877 0.4035194 0.3357155 4.6340268 3.125353 4.957207 0.9594409 0.3197342 0.6638069 0.32090417 0.2549333 0.3251667 0.07023333 6.426922e-01 2.137568e-13 FALSE TRUE
ENST00000401000 ENSG00000163125 HEK293_OSMI2_2hA HEK293_TMG_2hB RPRD2 protein_coding protein_coding 14.17196 12.09643 15.26835 0.5387877 0.4035194 0.3357155 4.4406417 5.656228 2.770832 0.5132160 0.4789553 -1.0268722 0.32926667 0.4695333 0.1807333 -0.28880000 3.336294e-04 2.137568e-13 FALSE TRUE
MSTRG.2164.2 ENSG00000163125 HEK293_OSMI2_2hA HEK293_TMG_2hB RPRD2 protein_coding   14.17196 12.09643 15.26835 0.5387877 0.4035194 0.3357155 0.9168336 0.000000 2.418517 0.0000000 0.5303137 7.9239315 0.05996667 0.0000000 0.1573000 0.15730000 2.137568e-13 2.137568e-13 FALSE TRUE
MSTRG.2164.6 ENSG00000163125 HEK293_OSMI2_2hA HEK293_TMG_2hB RPRD2 protein_coding   14.17196 12.09643 15.26835 0.5387877 0.4035194 0.3357155 2.3312329 1.596628 3.560363 0.5901835 0.2719462 1.1520353 0.16347083 0.1299000 0.2344000 0.10450000 2.518153e-01 2.137568e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163125 E001 1.5509899 0.0093609818 8.944859e-01 9.366028e-01 1 150363091 150363398 308 + 0.369 0.473 0.555
ENSG00000163125 E002 4.2246261 0.0545340016 1.152912e-01 2.132779e-01 1 150364147 150364196 50 + 0.785 0.619 -0.688
ENSG00000163125 E003 37.6528674 0.0287320593 1.011417e-01 1.922172e-01 1 150364197 150364529 333 + 1.600 1.568 -0.110
ENSG00000163125 E004 15.3624617 0.0566174814 2.398634e-01 3.739831e-01 1 150364530 150364649 120 + 1.225 1.202 -0.083
ENSG00000163125 E005 4.4504646 0.0519089619 1.493600e-01 2.607841e-01 1 150364650 150364654 5 + 0.785 0.660 -0.514
ENSG00000163125 E006 5.7245617 0.1222078576 2.823006e-01 4.222806e-01 1 150364655 150364671 17 + 0.855 0.790 -0.255
ENSG00000163125 E007 9.0544061 0.0102924313 7.302647e-02 1.483719e-01 1 150364672 150364696 25 + 1.038 0.949 -0.329
ENSG00000163125 E008 9.4469360 0.0206690186 3.093769e-02 7.379075e-02 1 150364697 150364707 11 + 1.079 0.930 -0.549
ENSG00000163125 E009 75.6279183 0.0150088944 4.323393e-05 2.473063e-04 1 150364708 150364919 212 + 1.944 1.786 -0.534
ENSG00000163125 E010 0.2966881 0.0270037787 2.250663e-01   1 150408906 150409052 147 + 0.187 0.000 -13.456
ENSG00000163125 E011 102.3361090 0.0039102342 4.730037e-08 5.128141e-07 1 150417596 150417725 130 + 2.060 1.938 -0.408
ENSG00000163125 E012 100.8532366 0.0049787376 2.740232e-05 1.645384e-04 1 150440923 150441023 101 + 2.035 1.962 -0.244
ENSG00000163125 E013 1.8069817 0.0076322187 2.521802e-02 6.232407e-02 1 150441024 150441623 600 + 0.566 0.253 -1.765
ENSG00000163125 E014 82.3660234 0.0006069171 9.676371e-15 3.189213e-13 1 150441881 150441958 78 + 1.992 1.805 -0.629
ENSG00000163125 E015 85.6365876 0.0059237007 1.181401e-04 6.052921e-04 1 150443231 150443283 53 + 1.965 1.892 -0.243
ENSG00000163125 E016 120.6743639 0.0003506405 9.755016e-10 1.449799e-08 1 150444251 150444377 127 + 2.110 2.038 -0.241
ENSG00000163125 E017 132.5538405 0.0003166577 2.120871e-06 1.640305e-05 1 150446226 150446401 176 + 2.128 2.109 -0.063
ENSG00000163125 E018 158.8137083 0.0062492079 1.345397e-03 5.127676e-03 1 150457288 150457570 283 + 2.208 2.193 -0.050
ENSG00000163125 E019 165.3519515 0.0025183353 6.465929e-05 3.542061e-04 1 150460060 150460317 258 + 2.223 2.211 -0.041
ENSG00000163125 E020 125.8779711 0.0035057793 1.095372e-04 5.659295e-04 1 150464527 150464727 201 + 2.114 2.081 -0.110
ENSG00000163125 E021 243.1171162 0.0005629363 6.881614e-07 5.918113e-06 1 150470561 150470980 420 + 2.378 2.387 0.028
ENSG00000163125 E022 405.1824022 0.0016403508 1.089208e-02 3.090723e-02 1 150470981 150471742 762 + 2.571 2.641 0.231
ENSG00000163125 E023 112.5020156 0.0010469618 5.461972e-01 6.764074e-01 1 150471743 150471882 140 + 1.977 2.128 0.504
ENSG00000163125 E024 1535.0092046 0.0132778362 9.754079e-09 1.205245e-07 1 150471883 150476566 4684 + 3.007 3.333 1.084
ENSG00000163125 E025 2.3625865 0.0070386481 7.773327e-02 1.558309e-01 1 150485045 150485172 128 + 0.317 0.694 1.879