ENSG00000163110

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317968 ENSG00000163110 HEK293_OSMI2_2hA HEK293_TMG_2hB PDLIM5 protein_coding protein_coding 10.75341 8.298232 13.1793 1.371107 0.802065 0.6667543 4.7790407 2.81808756 6.8302955 0.03387787 0.35969643 1.27423186 0.43733750 0.361266667 0.52476667 0.163500000 0.256123841 0.001758189 FALSE TRUE
ENST00000359265 ENSG00000163110 HEK293_OSMI2_2hA HEK293_TMG_2hB PDLIM5 protein_coding protein_coding 10.75341 8.298232 13.1793 1.371107 0.802065 0.6667543 0.6413041 0.57323416 0.8567971 0.06516952 0.09275517 0.57161912 0.06014167 0.070533333 0.06560000 -0.004933333 0.927162048 0.001758189 FALSE FALSE
ENST00000506632 ENSG00000163110 HEK293_OSMI2_2hA HEK293_TMG_2hB PDLIM5 protein_coding nonsense_mediated_decay 10.75341 8.298232 13.1793 1.371107 0.802065 0.6667543 0.7239483 0.03792807 1.2401246 0.03792807 0.64193702 4.70505743 0.05540833 0.004133333 0.09033333 0.086200000 0.434646692 0.001758189 TRUE TRUE
MSTRG.25195.6 ENSG00000163110 HEK293_OSMI2_2hA HEK293_TMG_2hB PDLIM5 protein_coding   10.75341 8.298232 13.1793 1.371107 0.802065 0.6667543 2.0507063 2.72656550 2.6013892 1.24008323 0.35508653 -0.06754889 0.20605000 0.289733333 0.19666667 -0.093066667 0.898303544 0.001758189 FALSE FALSE
MSTRG.25195.7 ENSG00000163110 HEK293_OSMI2_2hA HEK293_TMG_2hB PDLIM5 protein_coding   10.75341 8.298232 13.1793 1.371107 0.802065 0.6667543 0.9312037 1.37338609 0.3915169 0.19286358 0.08251067 -1.78467132 0.10395000 0.186400000 0.02953333 -0.156866667 0.001758189 0.001758189 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163110 E001 0.0000000       4 94451857 94451885 29 +      
ENSG00000163110 E002 0.9329388 0.2867213036 4.868434e-01 6.245541e-01 4 94451886 94451897 12 + 0.330 0.167 -1.273
ENSG00000163110 E003 0.9329388 0.2867213036 4.868434e-01 6.245541e-01 4 94451898 94451901 4 + 0.330 0.167 -1.273
ENSG00000163110 E004 1.8498561 0.0078410140 4.722030e-01 6.112611e-01 4 94451902 94451907 6 + 0.482 0.381 -0.534
ENSG00000163110 E005 6.3097682 0.0027522913 4.188214e-01 5.620729e-01 4 94451908 94451919 12 + 0.792 0.929 0.528
ENSG00000163110 E006 7.4104662 0.0033182617 3.621099e-01 5.065058e-01 4 94451920 94451927 8 + 0.851 0.996 0.544
ENSG00000163110 E007 9.2444146 0.0022925688 4.411836e-01 5.828272e-01 4 94451928 94451934 7 + 0.950 1.071 0.445
ENSG00000163110 E008 9.2444146 0.0022925688 4.411836e-01 5.828272e-01 4 94451935 94451941 7 + 0.950 1.071 0.445
ENSG00000163110 E009 9.2444146 0.0022925688 4.411836e-01 5.828272e-01 4 94451942 94451942 1 + 0.950 1.071 0.445
ENSG00000163110 E010 13.8398102 0.0046705065 4.152108e-01 5.586084e-01 4 94451943 94451955 13 + 1.113 1.228 0.411
ENSG00000163110 E011 33.1728715 0.0006595605 1.533478e-01 2.662299e-01 4 94451956 94451995 40 + 1.473 1.601 0.437
ENSG00000163110 E012 0.1451727 0.0436146254 1.000000e+00   4 94455245 94455246 2 + 0.088 0.000 -11.046
ENSG00000163110 E013 32.7098201 0.0018394849 1.820480e-01 3.037801e-01 4 94455247 94455266 20 + 1.470 1.595 0.429
ENSG00000163110 E014 64.8549420 0.0016425401 2.807149e-02 6.815579e-02 4 94455267 94455384 118 + 1.751 1.895 0.486
ENSG00000163110 E015 0.1482932 0.0406849411 2.610846e-01   4 94455385 94455542 158 + 0.000 0.167 12.408
ENSG00000163110 E016 4.3575557 0.1412245546 1.115123e-01 2.077751e-01 4 94455819 94456243 425 + 0.808 0.464 -1.505
ENSG00000163110 E017 17.2432214 0.0011081965 6.288697e-02 1.315216e-01 4 94456244 94457184 941 + 1.170 1.362 0.674
ENSG00000163110 E018 0.0000000       4 94489035 94489070 36 +      
ENSG00000163110 E019 33.9984347 0.0046524487 4.396586e-02 9.831676e-02 4 94523724 94523724 1 + 1.463 1.638 0.599
ENSG00000163110 E020 63.3567741 0.0089959017 1.314162e-01 2.361214e-01 4 94523725 94523830 106 + 1.742 1.886 0.484
ENSG00000163110 E021 36.6995402 0.0148863645 3.401431e-01 4.840967e-01 4 94523831 94523875 45 + 1.517 1.649 0.450
ENSG00000163110 E022 3.4622378 0.0048258291 2.877236e-04 1.330024e-03 4 94549791 94549793 3 + 0.328 0.905 2.637
ENSG00000163110 E023 14.5148819 0.0308148699 2.774200e-07 2.584956e-06 4 94549794 94549986 193 + 0.808 1.492 2.469
ENSG00000163110 E024 26.3260465 0.0007386525 5.664728e-09 7.321865e-08 4 94573351 94573393 43 + 1.537 1.120 -1.458
ENSG00000163110 E025 0.6060617 0.9240197727 5.486309e-01 6.784764e-01 4 94573394 94573735 342 + 0.282 0.000 -12.431
ENSG00000163110 E026 67.8599803 0.0005059632 6.390134e-12 1.373332e-10 4 94575616 94575942 327 + 1.909 1.621 -0.973
ENSG00000163110 E027 38.0391228 0.0005816532 1.460582e-05 9.341761e-05 4 94575943 94576034 92 + 1.647 1.420 -0.779
ENSG00000163110 E028 0.1472490 0.0437773317 1.000000e+00   4 94579221 94579369 149 + 0.089 0.000 -11.046
ENSG00000163110 E029 0.0000000       4 94579521 94579537 17 +      
ENSG00000163110 E030 0.0000000       4 94582547 94582716 170 +      
ENSG00000163110 E031 0.0000000       4 94582717 94582731 15 +      
ENSG00000163110 E032 0.0000000       4 94582732 94582999 268 +      
ENSG00000163110 E033 0.1515154 0.0439087417 1.000000e+00   4 94584401 94584985 585 + 0.089 0.000 -11.046
ENSG00000163110 E034 0.9578041 0.0121989077 3.335814e-01 4.773183e-01 4 94584986 94585003 18 + 0.328 0.167 -1.269
ENSG00000163110 E035 30.9011026 0.0006892999 1.192485e-01 2.188695e-01 4 94585565 94585626 62 + 1.511 1.450 -0.210
ENSG00000163110 E036 41.8921939 0.0192851528 1.528253e-01 2.654931e-01 4 94585627 94585737 111 + 1.647 1.551 -0.327
ENSG00000163110 E037 28.4351833 0.0082165890 2.013021e-02 5.175697e-02 4 94586408 94586444 37 + 1.501 1.346 -0.538
ENSG00000163110 E038 5.4435475 0.0038143124 1.642689e-03 6.097347e-03 4 94586989 94588216 1228 + 0.570 1.016 1.789
ENSG00000163110 E039 0.5848540 0.0945083890 2.715644e-02 6.631567e-02 4 94608059 94608178 120 + 0.000 0.383 13.787
ENSG00000163110 E040 0.1817044 0.0403637312 2.588064e-01   4 94610161 94610304 144 + 0.000 0.167 12.413
ENSG00000163110 E041 0.0000000       4 94611069 94611200 132 +      
ENSG00000163110 E042 64.2158454 0.0006021716 4.397953e-05 2.511996e-04 4 94618004 94618191 188 + 1.849 1.697 -0.515
ENSG00000163110 E043 64.8183391 0.0004280684 1.291189e-03 4.946351e-03 4 94640276 94640450 175 + 1.839 1.732 -0.362
ENSG00000163110 E044 69.8290780 0.0005416260 2.545987e-02 6.282461e-02 4 94654460 94654640 181 + 1.856 1.798 -0.194
ENSG00000163110 E045 0.1515154 0.0439087417 1.000000e+00   4 94656818 94656911 94 + 0.089 0.000 -11.046
ENSG00000163110 E046 59.4625396 0.0004434761 6.175504e-02 1.295777e-01 4 94657427 94657547 121 + 1.783 1.736 -0.160
ENSG00000163110 E047 54.7349603 0.0004834400 8.627111e-02 1.694302e-01 4 94662422 94662537 116 + 1.748 1.705 -0.146
ENSG00000163110 E048 39.3338091 0.0005757802 1.055470e-01 1.989326e-01 4 94663978 94664035 58 + 1.611 1.558 -0.180
ENSG00000163110 E049 214.9482409 0.0057865046 7.128954e-01 8.094837e-01 4 94664036 94666024 1989 + 2.312 2.332 0.065
ENSG00000163110 E050 317.3692901 0.0120963820 3.276151e-03 1.108059e-02 4 94666025 94668227 2203 + 2.414 2.594 0.601