ENSG00000163104

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354268 ENSG00000163104 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCAD1 protein_coding protein_coding 13.24571 3.029696 20.96312 0.345235 0.6290714 2.786542 2.0225062 0.69387736 3.08659804 0.36780159 1.55757143 2.137288 0.1384917 0.23393333 0.143366667 -0.09056667 9.514806e-01 1.318051e-10 FALSE TRUE
ENST00000359052 ENSG00000163104 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCAD1 protein_coding protein_coding 13.24571 3.029696 20.96312 0.345235 0.6290714 2.786542 5.2933928 0.79098396 9.06902247 0.11614383 1.95583777 3.502692 0.3781458 0.25930000 0.429400000 0.17010000 3.218758e-01 1.318051e-10 FALSE TRUE
ENST00000457823 ENSG00000163104 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCAD1 protein_coding protein_coding 13.24571 3.029696 20.96312 0.345235 0.6290714 2.786542 1.0056275 0.08512617 1.79324783 0.08512617 1.79324783 4.244612 0.0673000 0.03086667 0.090166667 0.05930000 8.129416e-01 1.318051e-10 FALSE TRUE
ENST00000509418 ENSG00000163104 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCAD1 protein_coding protein_coding 13.24571 3.029696 20.96312 0.345235 0.6290714 2.786542 0.4975584 1.40702938 0.05753868 0.33811301 0.03547418 -4.391012 0.1677292 0.46173333 0.002766667 -0.45896667 1.318051e-10 1.318051e-10 FALSE TRUE
MSTRG.25193.2 ENSG00000163104 HEK293_OSMI2_2hA HEK293_TMG_2hB SMARCAD1 protein_coding   13.24571 3.029696 20.96312 0.345235 0.6290714 2.786542 4.0742771 0.00000000 6.09902017 0.00000000 1.40588795 9.254797 0.2185542 0.00000000 0.293633333 0.29363333 7.031811e-08 1.318051e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163104 E001 0.1451727 0.0428281522 6.858630e-01   4 94207611 94207611 1 + 0.041 0.000 -9.055
ENSG00000163104 E002 1.0267042 0.0139956262 4.737862e-01 6.126867e-01 4 94207612 94207622 11 + 0.229 0.000 -11.846
ENSG00000163104 E003 24.1932035 0.0040893094 2.757533e-04 1.281036e-03 4 94207623 94207735 113 + 1.222 0.802 -1.555
ENSG00000163104 E004 0.0000000       4 94207841 94207844 4 +      
ENSG00000163104 E005 0.7490443 0.0940660560 7.814749e-01 8.595952e-01 4 94207845 94207864 20 + 0.175 0.000 -11.364
ENSG00000163104 E006 0.7490443 0.0940660560 7.814749e-01 8.595952e-01 4 94207865 94207865 1 + 0.175 0.000 -11.364
ENSG00000163104 E007 15.5768789 0.0011511666 6.881065e-01 7.902908e-01 4 94207866 94208070 205 + 1.010 1.067 0.209
ENSG00000163104 E008 0.1472490 0.0433819125 6.871232e-01   4 94208084 94208242 159 + 0.041 0.000 -9.039
ENSG00000163104 E009 81.4168572 0.0006391106 4.518662e-08 4.917267e-07 4 94208346 94208584 239 + 1.723 1.425 -1.017
ENSG00000163104 E010 0.7342825 0.0160540244 7.618143e-01 8.455841e-01 4 94213035 94213152 118 + 0.175 0.000 -11.361
ENSG00000163104 E011 88.0290803 0.0002980929 3.960828e-10 6.322607e-09 4 94226119 94226296 178 + 1.758 1.407 -1.198
ENSG00000163104 E012 91.6915642 0.0004388046 5.986560e-09 7.709440e-08 4 94233954 94234122 169 + 1.772 1.474 -1.013
ENSG00000163104 E013 58.0965404 0.0048054951 9.243496e-04 3.700426e-03 4 94236952 94237018 67 + 1.571 1.389 -0.623
ENSG00000163104 E014 73.5788049 0.0003243602 8.648759e-08 8.887402e-07 4 94240906 94241006 101 + 1.679 1.369 -1.061
ENSG00000163104 E015 0.5869198 0.1672559450 1.000000e+00 1.000000e+00 4 94248481 94248553 73 + 0.145 0.000 -11.037
ENSG00000163104 E016 76.9190659 0.0016761768 2.025136e-04 9.746120e-04 4 94249654 94249755 102 + 1.688 1.533 -0.529
ENSG00000163104 E017 79.5538096 0.0009225003 1.421319e-03 5.377542e-03 4 94250752 94250833 82 + 1.698 1.596 -0.346
ENSG00000163104 E018 166.7250038 0.0014307280 4.699841e-05 2.665781e-04 4 94252616 94253007 392 + 2.013 1.931 -0.273
ENSG00000163104 E019 1.0382438 0.0123659033 7.815264e-01 8.596269e-01 4 94253294 94253671 378 + 0.203 0.315 0.840
ENSG00000163104 E020 0.6653823 0.0170585026 4.022635e-01 5.459859e-01 4 94264528 94264706 179 + 0.113 0.316 1.843
ENSG00000163104 E021 119.3840264 0.0002995243 1.668727e-02 4.425062e-02 4 94264707 94264906 200 + 1.861 1.854 -0.023
ENSG00000163104 E022 0.8794552 0.0409239226 5.970915e-01 7.189140e-01 4 94270567 94270727 161 + 0.203 0.000 -11.623
ENSG00000163104 E023 76.6245647 0.0003536625 6.670057e-01 7.743542e-01 4 94270728 94270818 91 + 1.661 1.752 0.310
ENSG00000163104 E024 81.1686869 0.0003680216 5.482203e-01 6.780881e-01 4 94273617 94273716 100 + 1.686 1.768 0.277
ENSG00000163104 E025 58.4236887 0.0003920587 2.217608e-02 5.603844e-02 4 94274738 94274797 60 + 1.563 1.504 -0.200
ENSG00000163104 E026 46.6288181 0.0036824195 5.080941e-02 1.106172e-01 4 94274890 94274965 76 + 1.467 1.408 -0.202
ENSG00000163104 E027 90.0336828 0.0003493536 1.186894e-03 4.596914e-03 4 94276339 94276474 136 + 1.748 1.661 -0.295
ENSG00000163104 E028 100.6789097 0.0003001126 8.984379e-03 2.624131e-02 4 94277022 94277159 138 + 1.793 1.760 -0.110
ENSG00000163104 E029 84.4733825 0.0003127016 2.148758e-01 3.442967e-01 4 94278422 94278517 96 + 1.709 1.752 0.147
ENSG00000163104 E030 84.7974987 0.0003551572 3.333755e-01 4.770958e-01 4 94278616 94278733 118 + 1.708 1.768 0.204
ENSG00000163104 E031 23.0405035 0.0008310425 1.216612e-02 3.392856e-02 4 94278923 94278928 6 + 1.190 0.979 -0.764
ENSG00000163104 E032 102.7284054 0.0003216722 2.611820e-01 3.988179e-01 4 94278929 94279050 122 + 1.790 1.847 0.194
ENSG00000163104 E033 138.6315463 0.0005422130 6.181398e-01 7.358567e-01 4 94280592 94280780 189 + 1.914 2.010 0.322
ENSG00000163104 E034 100.5891929 0.0003159204 3.782575e-01 5.225337e-01 4 94281472 94281590 119 + 1.767 1.931 0.553
ENSG00000163104 E035 118.7557785 0.0006284189 4.755756e-03 1.524963e-02 4 94283121 94283303 183 + 1.824 2.074 0.839
ENSG00000163104 E036 106.5671620 0.0031723878 1.756516e-01 2.955333e-01 4 94284960 94285069 110 + 1.789 1.983 0.654
ENSG00000163104 E037 452.2464606 0.0356248397 1.645818e-07 1.603390e-06 4 94289473 94291292 1820 + 2.348 2.861 1.706