ENSG00000163071

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295213 ENSG00000163071 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA18 protein_coding protein_coding 0.9538543 0.7517324 1.526946 0.02565555 0.1725643 1.01271 0.16866722 0.06906697 0.32849782 0.06906697 0.09786790 2.0979995 0.18190000 0.09786667 0.21450000 0.11663333 0.45474368 0.02506939 FALSE TRUE
ENST00000419395 ENSG00000163071 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA18 protein_coding protein_coding 0.9538543 0.7517324 1.526946 0.02565555 0.1725643 1.01271 0.55572582 0.66572411 0.80877429 0.08364792 0.08251208 0.2770315 0.59893333 0.88080000 0.54260000 -0.33820000 0.11224053 0.02506939 FALSE TRUE
ENST00000505038 ENSG00000163071 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA18 protein_coding nonsense_mediated_decay 0.9538543 0.7517324 1.526946 0.02565555 0.1725643 1.01271 0.06525109 0.00000000 0.06349769 0.00000000 0.06349769 2.8776989 0.05665000 0.00000000 0.04626667 0.04626667 0.92236302 0.02506939 FALSE FALSE
ENST00000506829 ENSG00000163071 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA18 protein_coding processed_transcript 0.9538543 0.7517324 1.526946 0.02565555 0.1725643 1.01271 0.05156066 0.00000000 0.32617573 0.00000000 0.17061039 5.0711437 0.03039583 0.00000000 0.19660000 0.19660000 0.02506939 0.02506939   FALSE
ENST00000511028 ENSG00000163071 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA18 protein_coding retained_intron 0.9538543 0.7517324 1.526946 0.02565555 0.1725643 1.01271 0.05436569 0.00000000 0.00000000 0.00000000 0.00000000 0.0000000 0.06245833 0.00000000 0.00000000 0.00000000   0.02506939 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163071 E001 0.5891098 0.0186180122 9.949881e-02 1.897137e-01 4 52051304 52051408 105 + 0.310 0.000 -11.773
ENSG00000163071 E002 0.5933762 0.0220709850 1.004372e-01 1.911334e-01 4 52051409 52051411 3 + 0.311 0.000 -13.811
ENSG00000163071 E003 0.5933762 0.0220709850 1.004372e-01 1.911334e-01 4 52051412 52051415 4 + 0.311 0.000 -13.811
ENSG00000163071 E004 0.5933762 0.0220709850 1.004372e-01 1.911334e-01 4 52051416 52051418 3 + 0.311 0.000 -13.811
ENSG00000163071 E005 2.5778951 0.0238058200 2.830721e-01 4.231440e-01 4 52051419 52051460 42 + 0.616 0.420 -0.943
ENSG00000163071 E006 5.2832689 0.0052414795 5.425079e-01 6.732556e-01 4 52051461 52051541 81 + 0.829 0.738 -0.363
ENSG00000163071 E007 13.7412067 0.0400701507 5.872258e-01 7.105512e-01 4 52051542 52051791 250 + 1.202 1.108 -0.337
ENSG00000163071 E008 8.0721528 0.0025811700 1.702364e-01 2.884843e-01 4 52060419 52060524 106 + 1.017 0.850 -0.627
ENSG00000163071 E009 6.8396184 0.0034751424 4.893911e-01 6.268264e-01 4 52060782 52060897 116 + 0.920 0.825 -0.362
ENSG00000163071 E010 6.0560195 0.0030389172 3.709623e-01 5.153760e-01 4 52062220 52062332 113 + 0.891 0.769 -0.479
ENSG00000163071 E011 1.2587586 0.0108293996 1.047649e-01 1.977600e-01 4 52069821 52069916 96 + 0.451 0.148 -2.170
ENSG00000163071 E012 8.0250371 0.0021647147 2.808955e-01 4.207603e-01 4 52071917 52072156 240 + 1.006 0.875 -0.493
ENSG00000163071 E013 8.2784595 0.0031498056 8.035728e-01 8.749861e-01 4 52076779 52077040 262 + 0.995 0.959 -0.132
ENSG00000163071 E014 0.0000000       4 52078344 52078734 391 +      
ENSG00000163071 E015 8.7701657 0.0109908388 2.866281e-01 4.270545e-01 4 52078735 52078893 159 + 1.048 0.918 -0.484
ENSG00000163071 E016 8.7537049 0.0088600922 4.850652e-01 6.230069e-01 4 52079744 52079919 176 + 1.028 0.939 -0.328
ENSG00000163071 E017 6.5374464 0.0026707312 3.009221e-01 4.426973e-01 4 52082387 52082510 124 + 0.933 0.797 -0.522
ENSG00000163071 E018 0.3299976 0.0274424043 1.017064e-01   4 52082511 52082560 50 + 0.000 0.258 12.614
ENSG00000163071 E019 0.3299976 0.0274424043 1.017064e-01   4 52082561 52082664 104 + 0.000 0.258 12.614
ENSG00000163071 E020 5.4895254 0.0152638582 5.155046e-01 6.501741e-01 4 52084916 52084999 84 + 0.861 0.767 -0.371
ENSG00000163071 E021 5.9133015 0.1511326275 6.009308e-01 7.221118e-01 4 52094527 52094572 46 + 0.890 0.784 -0.413
ENSG00000163071 E022 65.5546556 0.0005351094 9.921485e-08 1.007934e-06 4 52094880 52097299 2420 + 1.739 1.908 0.572