ENSG00000163069

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381431 ENSG00000163069 HEK293_OSMI2_2hA HEK293_TMG_2hB SGCB protein_coding protein_coding 16.39646 11.52006 22.20689 1.278763 1.326938 0.9462574 5.570306 2.1549897 8.978061 0.37102683 0.4620059 2.0536497 0.30556250 0.18606667 0.4047000 0.21863333 4.734020e-09 4.73402e-09 FALSE TRUE
MSTRG.24867.1 ENSG00000163069 HEK293_OSMI2_2hA HEK293_TMG_2hB SGCB protein_coding   16.39646 11.52006 22.20689 1.278763 1.326938 0.9462574 0.977912 0.4992613 1.248813 0.04502075 0.2560337 1.3055858 0.05244583 0.04436667 0.0563000 0.01193333 7.685286e-01 4.73402e-09 TRUE TRUE
MSTRG.24867.3 ENSG00000163069 HEK293_OSMI2_2hA HEK293_TMG_2hB SGCB protein_coding   16.39646 11.52006 22.20689 1.278763 1.326938 0.9462574 3.647940 4.3939993 3.763129 0.46718844 0.1607099 -0.2230527 0.24224583 0.38356667 0.1708667 -0.21270000 2.717430e-06 4.73402e-09 FALSE TRUE
MSTRG.24867.4 ENSG00000163069 HEK293_OSMI2_2hA HEK293_TMG_2hB SGCB protein_coding   16.39646 11.52006 22.20689 1.278763 1.326938 0.9462574 5.586694 4.2856644 6.881849 0.46725813 0.3239620 0.6820098 0.36022500 0.37240000 0.3112667 -0.06113333 2.485831e-01 4.73402e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163069 E001 0.0000000       4 52014145 52014174 30 -      
ENSG00000163069 E002 138.1456455 0.0122142029 2.241800e-02 5.654629e-02 4 52020706 52021579 874 - 2.179 2.048 -0.439
ENSG00000163069 E003 308.3770940 0.0002110029 2.509133e-37 7.301809e-35 4 52021580 52023792 2213 - 2.565 2.291 -0.915
ENSG00000163069 E004 86.7168280 0.0003518494 1.957542e-05 1.217180e-04 4 52023793 52023969 177 - 1.871 2.024 0.515
ENSG00000163069 E005 131.2383270 0.0003183195 1.033854e-08 1.270585e-07 4 52023970 52024160 191 - 2.044 2.211 0.558
ENSG00000163069 E006 138.0415718 0.0002779923 2.088965e-06 1.618535e-05 4 52027968 52028099 132 - 2.079 2.212 0.446
ENSG00000163069 E007 94.9409821 0.0003995530 4.575422e-01 5.978715e-01 4 52028730 52028770 41 - 1.963 1.983 0.067
ENSG00000163069 E008 103.1989722 0.0012038526 2.353638e-02 5.885556e-02 4 52028771 52028828 58 - 1.976 2.052 0.254
ENSG00000163069 E009 133.1888822 0.0009472695 5.058234e-03 1.608992e-02 4 52028829 52028921 93 - 2.084 2.166 0.275
ENSG00000163069 E010 164.8029510 0.0002160833 1.834187e-03 6.708651e-03 4 52029678 52029863 186 - 2.181 2.258 0.257
ENSG00000163069 E011 1.0361675 0.0117666524 2.596738e-01 3.971167e-01 4 52031852 52031864 13 - 0.378 0.164 -1.601
ENSG00000163069 E012 4.1944506 0.0101185530 6.002685e-01 7.215311e-01 4 52031865 52031961 97 - 0.750 0.668 -0.341
ENSG00000163069 E013 98.2850407 0.0003476173 2.930745e-01 4.341089e-01 4 52033431 52033640 210 - 2.007 1.962 -0.152
ENSG00000163069 E014 0.2966881 0.0290785164 4.833632e-01   4 52038223 52038226 4 - 0.165 0.000 -8.794
ENSG00000163069 E015 45.0411216 0.0030437780 4.309665e-01 5.735682e-01 4 52038227 52038299 73 - 1.674 1.620 -0.186