ENSG00000163029

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351948 ENSG00000163029 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC6 protein_coding protein_coding 14.43483 3.237437 20.86251 0.3014014 0.4307301 2.68423 0.4074411 1.2092233 0.3720352 0.0911614 0.3720352 -1.674185 0.09486667 0.37733333 0.01856667 -0.35876667 0.010419956 0.002465926 FALSE TRUE
ENST00000448223 ENSG00000163029 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC6 protein_coding protein_coding 14.43483 3.237437 20.86251 0.3014014 0.4307301 2.68423 2.9031940 0.3771288 4.7801561 0.2718909 0.4942344 3.629187 0.20345417 0.13540000 0.22836667 0.09296667 0.510080464 0.002465926 FALSE TRUE
MSTRG.18000.3 ENSG00000163029 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC6 protein_coding   14.43483 3.237437 20.86251 0.3014014 0.4307301 2.68423 5.4850064 0.1053605 9.5145145 0.1053605 0.4404309 6.367424 0.25516667 0.02936667 0.45570000 0.42633333 0.002465926 0.002465926 FALSE TRUE
MSTRG.18000.4 ENSG00000163029 HEK293_OSMI2_2hA HEK293_TMG_2hB SMC6 protein_coding   14.43483 3.237437 20.86251 0.3014014 0.4307301 2.68423 4.3365461 1.3397850 4.5979675 0.3709034 0.4549449 1.771401 0.34146667 0.39826667 0.22103333 -0.17723333 0.225120305 0.002465926 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163029 E001 9.3828812 0.0144742152 3.358394e-04 1.523850e-03 2 17663812 17663962 151 - 0.799 1.237 1.619
ENSG00000163029 E002 19.5900245 0.0301708644 8.989267e-04 3.610480e-03 2 17663963 17664031 69 - 1.110 1.495 1.349
ENSG00000163029 E003 97.8650550 0.0151754617 1.979408e-04 9.550068e-04 2 17664032 17665125 1094 - 1.828 2.095 0.896
ENSG00000163029 E004 61.6574207 0.0010772190 1.002317e-13 2.848575e-12 2 17665126 17665446 321 - 1.587 1.965 1.277
ENSG00000163029 E005 64.6702144 0.0004736570 7.153137e-11 1.293567e-09 2 17665447 17665502 56 - 1.630 1.950 1.081
ENSG00000163029 E006 100.1903750 0.0006338543 6.106099e-10 9.426958e-09 2 17665503 17665613 111 - 1.839 2.093 0.851
ENSG00000163029 E007 97.9645355 0.0005984689 4.491912e-10 7.098592e-09 2 17666420 17666517 98 - 1.828 2.085 0.865
ENSG00000163029 E008 120.1263715 0.0003132854 6.629812e-09 8.450501e-08 2 17670423 17670575 153 - 1.929 2.144 0.723
ENSG00000163029 E009 91.7605890 0.0003062775 1.227131e-06 9.998979e-06 2 17678859 17678964 106 - 1.816 2.023 0.693
ENSG00000163029 E010 6.7515934 0.0024541940 1.158438e-01 2.140138e-01 2 17678965 17682016 3052 - 0.747 0.961 0.831
ENSG00000163029 E011 98.2783890 0.0002974240 4.906283e-08 5.299243e-07 2 17683638 17683763 126 - 1.840 2.063 0.749
ENSG00000163029 E012 110.1952969 0.0002475066 1.570721e-05 9.977813e-05 2 17695152 17695297 146 - 1.902 2.072 0.569
ENSG00000163029 E013 105.2006507 0.0003354652 1.136477e-01 2.108429e-01 2 17696289 17696426 138 - 1.906 1.971 0.218
ENSG00000163029 E014 108.3322954 0.0002758292 9.257696e-01 9.572751e-01 2 17700208 17700378 171 - 1.935 1.928 -0.026
ENSG00000163029 E015 65.1349688 0.0003802576 8.658790e-01 9.176293e-01 2 17701829 17701909 81 - 1.717 1.723 0.020
ENSG00000163029 E016 79.8437223 0.0003668186 3.897862e-01 5.338353e-01 2 17703157 17703292 136 - 1.812 1.763 -0.163
ENSG00000163029 E017 36.8574938 0.0006767057 3.044709e-01 4.464723e-01 2 17707219 17707227 9 - 1.488 1.405 -0.285
ENSG00000163029 E018 75.6085898 0.0003844925 5.005381e-03 1.594401e-02 2 17707228 17707379 152 - 1.806 1.643 -0.552
ENSG00000163029 E019 65.2958336 0.0004013795 1.409812e-02 3.844826e-02 2 17708639 17708753 115 - 1.741 1.588 -0.519
ENSG00000163029 E020 3.3290157 0.0047782279 7.197947e-01 8.145388e-01 2 17713385 17713580 196 - 0.536 0.598 0.284
ENSG00000163029 E021 95.5321827 0.0021412785 2.938384e-02 7.074291e-02 2 17714861 17715065 205 - 1.900 1.780 -0.406
ENSG00000163029 E022 100.3754802 0.0005531384 3.070772e-02 7.334290e-02 2 17716086 17716264 179 - 1.919 1.811 -0.365
ENSG00000163029 E023 43.4204267 0.0006679932 1.519021e-01 2.642504e-01 2 17716741 17716749 9 - 1.560 1.453 -0.368
ENSG00000163029 E024 88.9375417 0.0003556771 1.633494e-02 4.346538e-02 2 17716750 17716905 156 - 1.868 1.741 -0.430
ENSG00000163029 E025 58.9285145 0.0128360573 3.194921e-01 4.625732e-01 2 17717088 17717176 89 - 1.686 1.601 -0.288
ENSG00000163029 E026 91.5206208 0.0003129464 1.944382e-02 5.029764e-02 2 17718077 17718223 147 - 1.880 1.758 -0.411
ENSG00000163029 E027 76.9296853 0.0003488673 2.861014e-04 1.323333e-03 2 17720940 17721038 99 - 1.818 1.605 -0.724
ENSG00000163029 E028 82.1066081 0.0002967419 3.146842e-04 1.439582e-03 2 17721142 17721261 120 - 1.847 1.643 -0.690
ENSG00000163029 E029 81.5383644 0.0003245405 1.706313e-08 2.014808e-07 2 17725257 17725358 102 - 1.860 1.516 -1.166
ENSG00000163029 E030 54.3446043 0.0043255347 6.399322e-07 5.540825e-06 2 17726389 17726456 68 - 1.694 1.273 -1.446
ENSG00000163029 E031 34.1318933 0.0024043967 8.919849e-04 3.586113e-03 2 17726457 17726469 13 - 1.488 1.178 -1.083
ENSG00000163029 E032 46.5296971 0.0005341661 2.180473e-06 1.681801e-05 2 17731078 17731139 62 - 1.625 1.238 -1.340
ENSG00000163029 E033 62.2701851 0.0003709340 2.428309e-06 1.854534e-05 2 17731741 17731877 137 - 1.742 1.418 -1.108
ENSG00000163029 E034 73.1212017 0.0003881230 1.119204e-08 1.367317e-07 2 17738221 17738326 106 - 1.815 1.442 -1.273
ENSG00000163029 E035 0.4720498 0.2000886979 4.455336e-01 5.870673e-01 2 17740745 17740822 78 - 0.109 0.241 1.378
ENSG00000163029 E036 45.5633118 0.0494635878 4.741857e-04 2.061479e-03 2 17741612 17741621 10 - 1.624 1.137 -1.692
ENSG00000163029 E037 46.8383393 0.0583403543 5.234593e-03 1.657077e-02 2 17741622 17741678 57 - 1.628 1.240 -1.339
ENSG00000163029 E038 44.4536074 0.0579680019 5.080152e-02 1.106051e-01 2 17741679 17741729 51 - 1.593 1.337 -0.882
ENSG00000163029 E039 61.3656867 0.0258069734 4.573746e-04 1.996136e-03 2 17745827 17745951 125 - 1.741 1.368 -1.275
ENSG00000163029 E040 5.4019475 0.0700394402 2.517495e-02 6.223666e-02 2 17745952 17746412 461 - 0.780 0.241 -2.762
ENSG00000163029 E041 8.6165195 0.0019771240 2.310377e-01 3.637085e-01 2 17752978 17753001 24 - 0.919 0.736 -0.717
ENSG00000163029 E042 13.8568955 0.0013637610 1.436095e-02 3.904868e-02 2 17753002 17753064 63 - 1.124 0.791 -1.248
ENSG00000163029 E043 42.4012204 0.0007685393 6.897222e-06 4.757885e-05 2 17753626 17753830 205 - 1.585 1.199 -1.340
ENSG00000163029 E044 0.1515154 0.0429416655 1.000000e+00   2 17787815 17787921 107 - 0.058 0.001 -5.999
ENSG00000163029 E045 0.0000000       2 17797565 17797898 334 -      
ENSG00000163029 E046 0.0000000       2 17799151 17799225 75 -      
ENSG00000163029 E047 0.0000000       2 17799639 17799724 86 -      
ENSG00000163029 E048 0.0000000       2 17799725 17799760 36 -      
ENSG00000163029 E049 0.0000000       2 17800104 17800242 139 -