ENSG00000163026

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295148 ENSG00000163026 HEK293_OSMI2_2hA HEK293_TMG_2hB WDCP protein_coding protein_coding 13.617 10.26219 17.83827 2.043261 0.3545563 0.7970413 10.9883911 5.0028796 16.4951651 0.7342645 0.5763899 1.719206 0.74587500 0.4981333 0.924433333 0.42630000 2.261937e-07 2.261937e-07 FALSE TRUE
ENST00000406895 ENSG00000163026 HEK293_OSMI2_2hA HEK293_TMG_2hB WDCP protein_coding protein_coding 13.617 10.26219 17.83827 2.043261 0.3545563 0.7970413 0.6883527 0.4820322 1.2109758 0.4820322 0.3458683 1.311210 0.05542083 0.0529000 0.068366667 0.01546667 3.697070e-01 2.261937e-07 FALSE TRUE
MSTRG.18044.1 ENSG00000163026 HEK293_OSMI2_2hA HEK293_TMG_2hB WDCP protein_coding   13.617 10.26219 17.83827 2.043261 0.3545563 0.7970413 1.7432578 4.7560408 0.1003026 1.5057000 0.1003026 -5.433253 0.18719583 0.4460667 0.005466667 -0.44060000 2.227766e-05 2.261937e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163026 E001 1.0393871 0.0776490039 4.599447e-01 6.000092e-01 2 24029281 24029346 66 - 0.231 0.374 0.964
ENSG00000163026 E002 193.3635540 0.0069070203 1.140187e-11 2.350947e-10 2 24029347 24029697 351 - 2.130 2.451 1.069
ENSG00000163026 E003 493.4634644 0.0007416932 8.154755e-23 7.093177e-21 2 24029698 24030841 1144 - 2.612 2.790 0.595
ENSG00000163026 E004 167.8331996 0.0024633903 9.299231e-01 9.598985e-01 2 24030842 24031162 321 - 2.214 2.233 0.061
ENSG00000163026 E005 88.4727390 0.0008979373 4.318690e-01 5.743750e-01 2 24032829 24032946 118 - 1.950 1.935 -0.051
ENSG00000163026 E006 92.5872548 0.0046970304 3.892851e-02 8.905473e-02 2 24037677 24037797 121 - 1.996 1.900 -0.320
ENSG00000163026 E007 362.5788014 0.0037451003 3.475526e-07 3.173606e-06 2 24037798 24038916 1119 - 2.603 2.453 -0.499
ENSG00000163026 E008 50.3698052 0.0004951884 1.350413e-05 8.703537e-05 2 24038917 24038972 56 - 1.774 1.560 -0.725
ENSG00000163026 E009 57.3672566 0.0004768719 1.019265e-05 6.761565e-05 2 24038973 24039050 78 - 1.824 1.621 -0.687
ENSG00000163026 E010 167.7964088 0.0019030828 2.328937e-14 7.256745e-13 2 24039051 24039512 462 - 2.299 2.041 -0.863
ENSG00000163026 E011 51.3458556 0.0004730621 2.275746e-11 4.473730e-10 2 24047314 24047391 78 - 1.812 1.457 -1.206
ENSG00000163026 E012 0.3030308 0.3412101251 5.600820e-01   2 24049554 24049575 22 - 0.167 0.001 -8.621