ENSG00000163006

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295124 ENSG00000163006 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC138 protein_coding protein_coding 17.05158 4.567183 31.94732 0.1163761 1.498611 2.803615 5.9538991 1.3464997 11.054329 0.10473861 0.42559295 3.027955 0.29186667 0.2948667 0.34716667 0.0523000000 0.50801306 0.003053892 FALSE  
ENST00000412964 ENSG00000163006 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC138 protein_coding protein_coding 17.05158 4.567183 31.94732 0.1163761 1.498611 2.803615 1.9117471 0.5753399 3.959924 0.14715239 0.53649069 2.761765 0.11840833 0.1254667 0.12523333 -0.0002333333 1.00000000 0.003053892 FALSE  
ENST00000456512 ENSG00000163006 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC138 protein_coding protein_coding 17.05158 4.567183 31.94732 0.1163761 1.498611 2.803615 0.6537515 0.0000000 2.607462 0.00000000 1.31134943 8.032025 0.02587500 0.0000000 0.07800000 0.0780000000 0.39537328 0.003053892 FALSE  
ENST00000608781 ENSG00000163006 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC138 protein_coding protein_coding 17.05158 4.567183 31.94732 0.1163761 1.498611 2.803615 0.1080690 0.2643273 0.000000 0.26432725 0.00000000 -4.777826 0.01975417 0.0586000 0.00000000 -0.0586000000 0.48402400 0.003053892    
ENST00000609740 ENSG00000163006 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC138 protein_coding retained_intron 17.05158 4.567183 31.94732 0.1163761 1.498611 2.803615 2.9361754 1.2086788 5.269860 0.12337414 0.08310173 2.115182 0.24665417 0.2645000 0.16570000 -0.0988000000 0.02447287 0.003053892    
MSTRG.19009.1 ENSG00000163006 HEK293_OSMI2_2hA HEK293_TMG_2hB CCDC138 protein_coding   17.05158 4.567183 31.94732 0.1163761 1.498611 2.803615 0.6263591 0.3097434 1.278769 0.08329452 1.14215886 2.011007 0.05782083 0.0675000 0.03836667 -0.0291333333 0.46150054 0.003053892 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000163006 E001 0.9170311 0.0451483696 2.493707e-01 3.851786e-01 2 108786749 108786756 8 + 0.182 0.419 1.644
ENSG00000163006 E002 1.0642801 0.0122255951 3.332297e-01 4.769232e-01 2 108786757 108786760 4 + 0.218 0.420 1.324
ENSG00000163006 E003 2.1100125 0.0069046050 9.994780e-01 1.000000e+00 2 108786761 108786767 7 + 0.408 0.420 0.061
ENSG00000163006 E004 2.2615279 0.0063830224 9.154451e-01 9.504797e-01 2 108786768 108786768 1 + 0.430 0.420 -0.055
ENSG00000163006 E005 2.9999631 0.0051567973 5.675049e-01 6.942804e-01 2 108786769 108786770 2 + 0.524 0.420 -0.524
ENSG00000163006 E006 2.9999631 0.0051567973 5.675049e-01 6.942804e-01 2 108786771 108786772 2 + 0.524 0.420 -0.524
ENSG00000163006 E007 4.0414292 0.0041572650 2.694017e-01 4.079170e-01 2 108786773 108786778 6 + 0.629 0.420 -0.998
ENSG00000163006 E008 9.4200821 0.0037909514 1.517110e-02 4.087490e-02 2 108786779 108786787 9 + 0.945 0.537 -1.677
ENSG00000163006 E009 20.3530700 0.0009378962 5.718967e-02 1.217883e-01 2 108786788 108786804 17 + 1.230 1.032 -0.712
ENSG00000163006 E010 49.5216096 0.0006909366 8.336397e-02 1.648338e-01 2 108786805 108786915 111 + 1.588 1.482 -0.364
ENSG00000163006 E011 4.0774552 0.0582947884 6.882286e-01 7.904003e-01 2 108786916 108786933 18 + 0.614 0.537 -0.349
ENSG00000163006 E012 51.4136107 0.0006100224 1.035166e-01 1.958551e-01 2 108788032 108788089 58 + 1.601 1.504 -0.330
ENSG00000163006 E013 84.5646312 0.0003218054 6.199204e-04 2.606522e-03 2 108788852 108788966 115 + 1.823 1.645 -0.603
ENSG00000163006 E014 1.0224484 0.0697843993 4.596170e-02 1.019615e-01 2 108791555 108791674 120 + 0.143 0.539 2.657
ENSG00000163006 E015 42.7462027 0.0020988639 2.155799e-04 1.030817e-03 2 108791675 108791679 5 + 1.548 1.238 -1.077
ENSG00000163006 E016 65.0943606 0.0003812100 1.404742e-04 7.055669e-04 2 108791680 108791711 32 + 1.720 1.482 -0.814
ENSG00000163006 E017 59.9606776 0.0004360163 2.383387e-04 1.126364e-03 2 108791712 108791715 4 + 1.686 1.445 -0.822
ENSG00000163006 E018 96.4397703 0.0005801001 1.004323e-06 8.327830e-06 2 108791716 108791802 87 + 1.889 1.629 -0.881
ENSG00000163006 E019 117.1678070 0.0002966273 2.243083e-06 1.725876e-05 2 108794540 108794721 182 + 1.968 1.751 -0.732
ENSG00000163006 E020 100.4061953 0.0002879490 1.049016e-03 4.129000e-03 2 108798428 108798586 159 + 1.896 1.745 -0.510
ENSG00000163006 E021 32.0044156 0.0006548290 4.191245e-01 5.623760e-01 2 108804889 108804891 3 + 1.397 1.346 -0.177
ENSG00000163006 E022 90.4377147 0.0002851329 1.323380e-02 3.645848e-02 2 108804892 108805008 117 + 1.846 1.732 -0.384
ENSG00000163006 E023 88.1373897 0.0003028834 6.858671e-01 7.884909e-01 2 108812631 108812708 78 + 1.817 1.815 -0.007
ENSG00000163006 E024 106.7102997 0.0002964521 7.686614e-01 8.504882e-01 2 108812820 108812927 108 + 1.898 1.903 0.017
ENSG00000163006 E025 128.0513266 0.0002606717 3.118597e-01 4.543845e-01 2 108815941 108816105 165 + 1.981 1.957 -0.082
ENSG00000163006 E026 76.7442873 0.0033890662 8.947957e-01 9.367609e-01 2 108839185 108839301 117 + 1.758 1.769 0.036
ENSG00000163006 E027 106.1417412 0.0002894967 3.593513e-01 5.036881e-01 2 108846738 108846930 193 + 1.889 1.949 0.201
ENSG00000163006 E028 84.9444174 0.0003425771 9.558311e-03 2.767993e-02 2 108856794 108856927 134 + 1.777 1.920 0.484
ENSG00000163006 E029 50.2330064 0.0004976091 3.228697e-04 1.472335e-03 2 108856928 108856970 43 + 1.535 1.769 0.795
ENSG00000163006 E030 4.8259679 0.0188815466 1.291253e-02 3.570894e-02 2 108865497 108865719 223 + 0.557 0.962 1.647
ENSG00000163006 E031 67.6394265 0.0004517409 1.197521e-03 4.632013e-03 2 108873451 108873589 139 + 1.671 1.861 0.641
ENSG00000163006 E032 100.7859868 0.0078547984 4.460834e-05 2.543847e-04 2 108876088 108876582 495 + 1.824 2.086 0.881
ENSG00000163006 E033 40.2335974 0.0099826176 7.017121e-01 8.007640e-01 2 108882191 108882670 480 + 1.488 1.471 -0.059
ENSG00000163006 E034 26.9066871 0.0091818681 9.945921e-01 1.000000e+00 2 108882671 108882791 121 + 1.315 1.330 0.053
ENSG00000163006 E035 200.1109840 0.0022050776 9.453661e-08 9.639223e-07 2 108882792 108885101 2310 + 2.129 2.338 0.698
ENSG00000163006 E036 37.5884628 0.0088863799 3.388105e-16 1.362484e-14 2 108885102 108885477 376 + 1.284 1.903 2.118