ENSG00000162923

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000480676 ENSG00000162923 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR26 protein_coding protein_coding 41.65183 32.66218 52.0039 1.686604 1.030732 0.6708346 8.256332 7.5876838 8.252304 1.0418114 0.3748135 0.1209846 0.20273333 0.23023333 0.15860000 -0.07163333 4.007421e-02 1.293936e-08 FALSE TRUE
ENST00000486652 ENSG00000162923 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR26 protein_coding nonsense_mediated_decay 41.65183 32.66218 52.0039 1.686604 1.030732 0.6708346 2.137588 3.7759835 1.754617 0.4662935 0.1178293 -1.1013130 0.05679167 0.11566667 0.03376667 -0.08190000 1.293936e-08 1.293936e-08 TRUE TRUE
ENST00000651911 ENSG00000162923 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR26 protein_coding protein_coding 41.65183 32.66218 52.0039 1.686604 1.030732 0.6708346 4.702634 3.4627091 6.873194 0.8093983 0.1098780 0.9870166 0.11962083 0.10396667 0.13223333 0.02826667 5.701075e-01 1.293936e-08 FALSE TRUE
ENST00000678555 ENSG00000162923 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR26 protein_coding protein_coding 41.65183 32.66218 52.0039 1.686604 1.030732 0.6708346 14.268138 12.2062020 16.546251 0.4620834 0.8870966 0.4385802 0.34472083 0.37486667 0.31773333 -0.05713333 1.919500e-01 1.293936e-08 FALSE TRUE
MSTRG.3130.6 ENSG00000162923 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR26 protein_coding   41.65183 32.66218 52.0039 1.686604 1.030732 0.6708346 3.372868 0.8091148 6.934530 0.8091148 0.8807908 3.0837394 0.07224583 0.02413333 0.13410000 0.10996667 8.601340e-02 1.293936e-08 TRUE TRUE
MSTRG.3130.8 ENSG00000162923 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR26 protein_coding   41.65183 32.66218 52.0039 1.686604 1.030732 0.6708346 6.766080 3.5773699 9.364309 0.4842788 0.5768362 1.3857858 0.15298333 0.11170000 0.17976667 0.06806667 1.217388e-01 1.293936e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162923 E001 1.4779251 0.0222171944 7.793172e-01 8.580637e-01 1 224385146 224385160 15 - 0.368 0.413 0.250
ENSG00000162923 E002 6.4535784 0.0025221652 1.116131e-01 2.079172e-01 1 224385161 224385183 23 - 0.783 0.970 0.715
ENSG00000162923 E003 13.6038780 0.0012669408 2.611651e-06 1.982011e-05 1 224385184 224385213 30 - 0.914 1.343 1.545
ENSG00000162923 E004 92.2243537 0.0003220612 1.736257e-02 4.573982e-02 1 224385214 224385665 452 - 1.930 2.011 0.272
ENSG00000162923 E005 177.8801817 0.0016922361 9.987472e-03 2.873300e-02 1 224385666 224386192 527 - 2.289 2.197 -0.309
ENSG00000162923 E006 102.7533679 0.0037819616 5.461474e-05 3.047958e-04 1 224386193 224386502 310 - 2.090 1.891 -0.669
ENSG00000162923 E007 736.5996016 0.0009072327 4.242142e-18 2.165035e-16 1 224386503 224389135 2633 - 2.935 2.760 -0.579
ENSG00000162923 E008 48.8007762 0.0004432689 1.242063e-01 2.259833e-01 1 224389136 224389183 48 - 1.664 1.734 0.236
ENSG00000162923 E009 524.3023179 0.0006063408 1.061962e-28 1.592918e-26 1 224389184 224389552 369 - 2.618 2.820 0.673
ENSG00000162923 E010 685.3717158 0.0001471129 1.107494e-25 1.292739e-23 1 224389553 224389832 280 - 2.768 2.907 0.463
ENSG00000162923 E011 277.2379577 0.0011431982 9.524285e-05 4.997171e-04 1 224389833 224389860 28 - 2.395 2.490 0.316
ENSG00000162923 E012 3.2216489 0.7802809435 3.021417e-01 4.439985e-01 1 224393222 224393354 133 - 0.765 0.344 -2.001
ENSG00000162923 E013 557.2557566 0.0001241351 3.188771e-14 9.745169e-13 1 224393828 224394013 186 - 2.693 2.801 0.362
ENSG00000162923 E014 2.1486074 0.0068468716 1.480132e-01 2.589718e-01 1 224397727 224398096 370 - 0.595 0.340 -1.304
ENSG00000162923 E015 494.9961065 0.0001347120 1.935961e-07 1.859942e-06 1 224398097 224398226 130 - 2.658 2.735 0.256
ENSG00000162923 E016 394.1515665 0.0001499973 4.144228e-08 4.545311e-07 1 224398515 224398593 79 - 2.552 2.644 0.307
ENSG00000162923 E017 526.7999862 0.0002185072 3.783149e-03 1.253443e-02 1 224398889 224399034 146 - 2.703 2.743 0.132
ENSG00000162923 E018 527.8161382 0.0010365593 5.599909e-01 6.880560e-01 1 224400950 224401069 120 - 2.720 2.726 0.020
ENSG00000162923 E019 12.2032863 0.0134821199 4.332061e-01 5.756241e-01 1 224402004 224402109 106 - 1.149 1.056 -0.335
ENSG00000162923 E020 495.2908771 0.0001868032 6.832418e-01 7.865038e-01 1 224404430 224404570 141 - 2.701 2.687 -0.048
ENSG00000162923 E021 406.5159401 0.0006339832 2.986461e-01 4.401042e-01 1 224411427 224411562 136 - 2.622 2.592 -0.100
ENSG00000162923 E022 137.4640966 0.0002313402 2.130015e-02 5.422048e-02 1 224411563 224411565 3 - 2.174 2.095 -0.265
ENSG00000162923 E023 5.5810753 0.0390884221 4.840122e-01 6.220397e-01 1 224412909 224413252 344 - 0.854 0.734 -0.476
ENSG00000162923 E024 2.8076576 0.0055980989 9.065172e-01 9.445959e-01 1 224413253 224413335 83 - 0.565 0.577 0.058
ENSG00000162923 E025 359.3733931 0.0002007604 2.279978e-04 1.083250e-03 1 224418260 224418398 139 - 2.588 2.507 -0.269
ENSG00000162923 E026 178.8575868 0.0002443715 6.935392e-05 3.768829e-04 1 224418399 224418416 18 - 2.301 2.183 -0.394
ENSG00000162923 E027 0.7749669 0.1555778376 4.174142e-01 5.607701e-01 1 224419445 224419517 73 - 0.316 0.145 -1.426
ENSG00000162923 E028 199.6641588 0.0002584840 1.552769e-07 1.520167e-06 1 224419518 224419548 31 - 2.360 2.213 -0.491
ENSG00000162923 E029 171.6349788 0.0002033742 3.600760e-10 5.785863e-09 1 224419549 224419561 13 - 2.308 2.122 -0.622
ENSG00000162923 E030 215.4021434 0.0002254762 6.691939e-09 8.523382e-08 1 224419562 224419615 54 - 2.395 2.240 -0.520
ENSG00000162923 E031 285.5005098 0.0002129217 7.178167e-04 2.962835e-03 1 224424518 224424654 137 - 2.492 2.409 -0.274
ENSG00000162923 E032 4.0976519 0.0039458114 1.765609e-01 2.967725e-01 1 224424655 224424719 65 - 0.783 0.577 -0.869
ENSG00000162923 E033 4.5873699 0.0060587897 4.688612e-01 6.082191e-01 1 224429297 224431476 2180 - 0.802 0.695 -0.432
ENSG00000162923 E034 85.8237865 0.0003568347 3.700272e-01 5.144352e-01 1 224431477 224431524 48 - 1.952 1.909 -0.145
ENSG00000162923 E035 194.5641957 0.0002885874 9.362703e-06 6.264962e-05 1 224431525 224431581 57 - 2.341 2.214 -0.425
ENSG00000162923 E036 248.3714908 0.0016929123 7.261526e-04 2.992939e-03 1 224431682 224431781 100 - 2.440 2.328 -0.374
ENSG00000162923 E037 1.3349293 0.0101024520 5.658061e-01 6.928464e-01 1 224433096 224433265 170 - 0.316 0.413 0.572
ENSG00000162923 E038 431.5739534 0.0052559210 4.559066e-04 1.990049e-03 1 224433684 224434797 1114 - 2.692 2.546 -0.486
ENSG00000162923 E039 0.1451727 0.0434254919 7.173012e-01   1 224435717 224435891 175 - 0.103 0.000 -8.870
ENSG00000162923 E040 0.0000000       1 224436821 224437033 213 -