ENSG00000162889

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367103 ENSG00000162889 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAPK2 protein_coding protein_coding 53.05154 90.98275 33.40355 3.009646 0.2932715 -1.445318 29.77122 47.51726 21.921802 3.0938948 0.5076902 -1.115731 0.5807708 0.5213000 0.6561000 0.1348000 3.476895e-04 9.564119e-08 FALSE TRUE
MSTRG.2953.6 ENSG00000162889 HEK293_OSMI2_2hA HEK293_TMG_2hB MAPKAPK2 protein_coding   53.05154 90.98275 33.40355 3.009646 0.2932715 -1.445318 19.39319 37.91941 9.195873 0.4502458 0.1766639 -2.042691 0.3424167 0.4175667 0.2753333 -0.1422333 9.564119e-08 9.564119e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162889 E001 6.041025 0.0416891804 8.896360e-01 9.334611e-01 1 206684905 206684943 39 + 0.783 0.807 0.098
ENSG00000162889 E002 7.255685 0.0670338696 9.076366e-01 9.453811e-01 1 206684944 206684994 51 + 0.818 0.884 0.256
ENSG00000162889 E003 6.080677 0.1002131766 6.491296e-01 7.604798e-01 1 206684995 206684995 1 + 0.704 0.832 0.515
ENSG00000162889 E004 21.970721 0.0071124295 5.256147e-02 1.137194e-01 1 206684996 206685209 214 + 1.385 1.270 -0.401
ENSG00000162889 E005 275.723543 0.0042817774 1.606629e-01 2.759872e-01 1 206685210 206685508 299 + 2.378 2.381 0.011
ENSG00000162889 E006 485.061458 0.0018499843 1.690486e-03 6.252830e-03 1 206728710 206728849 140 + 2.645 2.619 -0.088
ENSG00000162889 E007 3.276381 0.0049236076 9.678071e-01 9.838927e-01 1 206728934 206729034 101 + 0.548 0.595 0.214
ENSG00000162889 E008 464.833989 0.0005356442 1.139470e-03 4.435548e-03 1 206729035 206729099 65 + 2.615 2.603 -0.041
ENSG00000162889 E009 6.209930 0.0131319309 9.581300e-01 9.777472e-01 1 206729100 206729108 9 + 0.782 0.822 0.159
ENSG00000162889 E010 277.718447 0.0001548396 4.471440e-04 1.955992e-03 1 206729396 206729398 3 + 2.405 2.376 -0.096
ENSG00000162889 E011 496.716693 0.0002099101 1.444366e-05 9.245848e-05 1 206729399 206729475 77 + 2.653 2.629 -0.082
ENSG00000162889 E012 687.334865 0.0006853793 5.507438e-08 5.881109e-07 1 206729972 206730098 127 + 2.809 2.764 -0.150
ENSG00000162889 E013 480.523791 0.0001867069 2.335138e-08 2.686657e-07 1 206730688 206730763 76 + 2.657 2.609 -0.158
ENSG00000162889 E014 710.959717 0.0002501988 2.904654e-06 2.180269e-05 1 206731138 206731262 125 + 2.804 2.785 -0.063
ENSG00000162889 E015 14.036158 0.0193005944 5.170758e-05 2.902387e-04 1 206731288 206731639 352 + 1.376 0.982 -1.404
ENSG00000162889 E016 593.253484 0.0001235874 9.617394e-03 2.782296e-02 1 206731640 206731725 86 + 2.703 2.715 0.040
ENSG00000162889 E017 10.493192 0.0018199188 4.970214e-01 6.335909e-01 1 206731806 206731838 33 + 1.026 1.000 -0.094
ENSG00000162889 E018 569.324045 0.0004680822 1.137397e-01 2.109805e-01 1 206731839 206731919 81 + 2.675 2.700 0.084
ENSG00000162889 E019 5.744403 0.0029273591 1.776544e-02 4.663445e-02 1 206731920 206732037 118 + 0.959 0.697 -1.024
ENSG00000162889 E020 12.487087 0.0014239427 1.350242e-01 2.411222e-01 1 206732038 206732084 47 + 1.151 1.051 -0.358
ENSG00000162889 E021 29.265226 0.0015984401 1.275782e-02 3.534301e-02 1 206732085 206732574 490 + 1.510 1.388 -0.419
ENSG00000162889 E022 325.567749 0.0001778095 5.386920e-02 1.160214e-01 1 206732575 206732577 3 + 2.443 2.454 0.038
ENSG00000162889 E023 3472.748010 0.0024004187 6.949815e-15 2.345665e-13 1 206732578 206734281 1704 + 3.333 3.522 0.628