ENSG00000162813

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322067 ENSG00000162813 HEK293_OSMI2_2hA HEK293_TMG_2hB BPNT1 protein_coding protein_coding 25.5343 10.75264 39.74889 3.249558 0.6155116 1.885245 10.5509425 5.9911844 13.9520720 1.6524039 1.4903155 1.218194 0.48696250 0.5647000 0.351733333 -0.21296667 1.179927e-02 8.3811e-34 FALSE TRUE
ENST00000354807 ENSG00000162813 HEK293_OSMI2_2hA HEK293_TMG_2hB BPNT1 protein_coding protein_coding 25.5343 10.75264 39.74889 3.249558 0.6155116 1.885245 0.5164848 0.0000000 2.1282209 0.0000000 1.0847861 7.740267 0.01271667 0.0000000 0.053500000 0.05350000 3.417780e-01 8.3811e-34 FALSE TRUE
ENST00000414869 ENSG00000162813 HEK293_OSMI2_2hA HEK293_TMG_2hB BPNT1 protein_coding protein_coding 25.5343 10.75264 39.74889 3.249558 0.6155116 1.885245 0.4018835 1.4655031 0.2499942 0.9421987 0.2499942 -2.504656 0.04329167 0.1183667 0.006133333 -0.11223333 2.912130e-01 8.3811e-34 FALSE TRUE
ENST00000498791 ENSG00000162813 HEK293_OSMI2_2hA HEK293_TMG_2hB BPNT1 protein_coding protein_coding 25.5343 10.75264 39.74889 3.249558 0.6155116 1.885245 4.6367677 0.0000000 7.8829432 0.0000000 0.4882308 9.624420 0.12136250 0.0000000 0.198133333 0.19813333 8.381100e-34 8.3811e-34 FALSE FALSE
MSTRG.3070.6 ENSG00000162813 HEK293_OSMI2_2hA HEK293_TMG_2hB BPNT1 protein_coding   25.5343 10.75264 39.74889 3.249558 0.6155116 1.885245 3.0826806 1.2290555 5.5671721 0.3495548 1.6144048 2.170293 0.10309583 0.1248000 0.139633333 0.01483333 9.333504e-01 8.3811e-34 FALSE TRUE
MSTRG.3070.7 ENSG00000162813 HEK293_OSMI2_2hA HEK293_TMG_2hB BPNT1 protein_coding   25.5343 10.75264 39.74889 3.249558 0.6155116 1.885245 4.1570415 0.7742067 7.2375010 0.4186954 0.1320476 3.208178 0.14056250 0.0701000 0.182066667 0.11196667 4.094925e-01 8.3811e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162813 E001 2.0712115 0.0079352667 2.163564e-02 5.492171e-02 1 220057482 220057483 2 - 0.313 0.699 1.921
ENSG00000162813 E002 16.3681995 0.0012541500 4.855587e-14 1.443396e-12 1 220057484 220057730 247 - 0.913 1.550 2.263
ENSG00000162813 E003 48.8399599 0.0007564871 7.155680e-15 2.411281e-13 1 220057731 220057917 187 - 1.515 1.916 1.360
ENSG00000162813 E004 116.2706793 0.0046933384 7.814991e-08 8.102707e-07 1 220057918 220058090 173 - 1.953 2.205 0.846
ENSG00000162813 E005 108.7081402 0.0003512858 5.399997e-07 4.745620e-06 1 220058091 220058162 72 - 1.958 2.140 0.609
ENSG00000162813 E006 117.4744041 0.0003259160 4.691972e-07 4.173537e-06 1 220058163 220058238 76 - 1.994 2.170 0.590
ENSG00000162813 E007 247.1078537 0.0014212545 1.528567e-06 1.220065e-05 1 220058239 220058651 413 - 2.327 2.468 0.470
ENSG00000162813 E008 222.3126399 0.0002788066 2.998031e-02 7.192199e-02 1 220058652 220058945 294 - 2.313 2.373 0.201
ENSG00000162813 E009 131.7872470 0.0029053780 7.186624e-01 8.136815e-01 1 220058946 220058992 47 - 2.103 2.112 0.029
ENSG00000162813 E010 184.9735745 0.0005242963 6.820244e-01 7.855847e-01 1 220059686 220059791 106 - 2.249 2.266 0.059
ENSG00000162813 E011 158.0431398 0.0019510218 3.842875e-01 5.284553e-01 1 220062757 220062798 42 - 2.195 2.166 -0.098
ENSG00000162813 E012 118.1552830 0.0007924077 1.485693e-01 2.597267e-01 1 220062799 220062810 12 - 2.077 2.031 -0.155
ENSG00000162813 E013 194.4925998 0.0002285036 1.308990e-01 2.354087e-01 1 220062811 220062911 101 - 2.288 2.255 -0.110
ENSG00000162813 E014 100.6718354 0.0014550241 5.622275e-01 6.898846e-01 1 220062912 220062915 4 - 2.000 1.984 -0.051
ENSG00000162813 E015 149.7917187 0.0003291226 1.165218e-01 2.149813e-01 1 220062916 220062954 39 - 2.179 2.138 -0.135
ENSG00000162813 E016 10.1319346 0.0029723451 2.093668e-02 5.345366e-02 1 220066073 220066117 45 - 1.108 0.845 -0.980
ENSG00000162813 E017 0.3030308 0.4228998920 7.991013e-01   1 220067015 220067029 15 - 0.154 0.000 -10.131
ENSG00000162813 E018 0.5997190 0.1896040690 2.871505e-01 4.276241e-01 1 220067030 220067125 96 - 0.267 0.000 -11.127
ENSG00000162813 E019 0.7362571 0.0182122469 6.488751e-01 7.602770e-01 1 220067126 220067301 176 - 0.213 0.301 0.657
ENSG00000162813 E020 180.9875360 0.0003800914 2.140941e-02 5.445102e-02 1 220067302 220067383 82 - 2.265 2.208 -0.193
ENSG00000162813 E021 103.2882227 0.0037899099 1.962588e-01 3.215401e-01 1 220067384 220067393 10 - 2.021 1.969 -0.175
ENSG00000162813 E022 137.8487024 0.0004935160 1.952345e-01 3.202829e-01 1 220069384 220069432 49 - 2.140 2.105 -0.118
ENSG00000162813 E023 165.1105454 0.0002720850 1.259265e-04 6.409220e-04 1 220072850 220072957 108 - 2.237 2.127 -0.367
ENSG00000162813 E024 224.5891894 0.0001981379 2.411688e-05 1.468429e-04 1 220073967 220074071 105 - 2.368 2.267 -0.337
ENSG00000162813 E025 200.1488794 0.0001838402 8.159706e-09 1.022714e-07 1 220079727 220079854 128 - 2.333 2.182 -0.503
ENSG00000162813 E026 21.1043912 0.0008737431 2.265194e-01 3.582507e-01 1 220089644 220089685 42 - 1.357 1.268 -0.313
ENSG00000162813 E027 153.1663881 0.0002153473 2.320865e-12 5.365889e-11 1 220089686 220089951 266 - 2.233 2.013 -0.735
ENSG00000162813 E028 1.1834285 0.0547143367 7.176840e-01 8.129867e-01 1 220090287 220090462 176 - 0.313 0.396 0.495