ENSG00000162769

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366971 ENSG00000162769 HEK293_OSMI2_2hA HEK293_TMG_2hB FLVCR1 protein_coding protein_coding 10.57832 4.545482 14.72502 0.4556218 0.3447207 1.693574 8.8603434 3.93179416 11.911225 0.25381963 0.2750138 1.596608 0.82915000 0.870900000 0.8089667 -0.06193333 0.433430976 0.001294442 FALSE  
ENST00000474693 ENSG00000162769 HEK293_OSMI2_2hA HEK293_TMG_2hB FLVCR1 protein_coding processed_transcript 10.57832 4.545482 14.72502 0.4556218 0.3447207 1.693574 0.4659958 0.04655303 1.190825 0.04655303 0.1191460 4.408278 0.04537500 0.008533333 0.0813000 0.07276667 0.001294442 0.001294442    
MSTRG.3035.2 ENSG00000162769 HEK293_OSMI2_2hA HEK293_TMG_2hB FLVCR1 protein_coding   10.57832 4.545482 14.72502 0.4556218 0.3447207 1.693574 0.8412134 0.23001784 1.310768 0.04424239 0.3385745 2.460163 0.07726667 0.050433333 0.0884000 0.03796667 0.458638228 0.001294442 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162769 E001 79.8521515 0.0003912482 1.139680e-01 2.113026e-01 1 212858275 212858784 510 + 1.925 1.826 -0.334
ENSG00000162769 E002 73.9795996 0.0011530828 6.109849e-02 1.284840e-01 1 212858785 212858915 131 + 1.899 1.780 -0.402
ENSG00000162769 E003 102.1332253 0.0013618984 3.987897e-01 5.425325e-01 1 212858916 212859190 275 + 2.019 1.952 -0.227
ENSG00000162769 E004 0.8889184 0.0134411630 4.587348e-01 5.990291e-01 1 212863631 212863724 94 + 0.324 0.170 -1.210
ENSG00000162769 E005 86.0211682 0.0003762788 7.420759e-01 8.310911e-01 1 212863725 212863869 145 + 1.930 1.911 -0.065
ENSG00000162769 E006 2.6062742 0.0278628376 5.646068e-01 6.918501e-01 1 212864393 212864411 19 + 0.589 0.464 -0.593
ENSG00000162769 E007 5.8223971 0.0051435332 2.226978e-01 3.535948e-01 1 212864412 212864519 108 + 0.883 0.684 -0.795
ENSG00000162769 E008 1.4307842 0.0712788069 8.248825e-01 8.896640e-01 1 212870054 212870166 113 + 0.367 0.387 0.117
ENSG00000162769 E009 90.2919242 0.0003773799 4.285012e-01 5.712515e-01 1 212872678 212872818 141 + 1.944 1.943 -0.006
ENSG00000162769 E010 59.5108161 0.0006079702 8.566927e-01 9.114017e-01 1 212883371 212883408 38 + 1.772 1.748 -0.081
ENSG00000162769 E011 58.5734946 0.0004691679 5.243924e-01 6.579141e-01 1 212883409 212883438 30 + 1.757 1.756 -0.005
ENSG00000162769 E012 99.4739718 0.0003226832 2.092551e-02 5.343265e-02 1 212885293 212885396 104 + 1.965 2.017 0.175
ENSG00000162769 E013 2.5088852 0.0061269865 1.357026e-02 3.723864e-02 1 212885397 212885565 169 + 0.657 0.170 -2.887
ENSG00000162769 E014 96.0371282 0.0003585792 1.073326e-02 3.053060e-02 1 212887891 212888001 111 + 1.950 2.012 0.210
ENSG00000162769 E015 107.7094336 0.0003309349 4.491271e-05 2.559202e-04 1 212888489 212888594 106 + 1.979 2.088 0.366
ENSG00000162769 E016 117.3408996 0.0002631948 8.389706e-08 8.646186e-07 1 212889146 212889257 112 + 2.002 2.145 0.481
ENSG00000162769 E017 85.9701956 0.0003086391 7.643505e-07 6.513603e-06 1 212894986 212895053 68 + 1.863 2.020 0.529
ENSG00000162769 E018 871.4108625 0.0031433622 3.916870e-05 2.262808e-04 1 212895216 212899363 4148 + 2.960 2.849 -0.370