ENSG00000162736

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000294785 ENSG00000162736 HEK293_OSMI2_2hA HEK293_TMG_2hB NCSTN protein_coding protein_coding 60.5238 62.39314 48.00903 1.743175 0.6606576 -0.3780122 38.753623 38.083440 33.393413 2.5375925 0.3439927 -0.1895471 0.64587500 0.61083333 0.69586667 0.08503333 0.3340703996 0.0007249688 FALSE TRUE
ENST00000469159 ENSG00000162736 HEK293_OSMI2_2hA HEK293_TMG_2hB NCSTN protein_coding retained_intron 60.5238 62.39314 48.00903 1.743175 0.6606576 -0.3780122 7.501686 13.259494 2.645124 2.8779984 0.2953210 -2.3212625 0.11937500 0.21273333 0.05496667 -0.15776667 0.0007249688 0.0007249688   FALSE
ENST00000491390 ENSG00000162736 HEK293_OSMI2_2hA HEK293_TMG_2hB NCSTN protein_coding retained_intron 60.5238 62.39314 48.00903 1.743175 0.6606576 -0.3780122 5.982252 3.678011 4.965977 0.3467178 0.3725091 0.4321369 0.09654583 0.05873333 0.10330000 0.04456667 0.0007289258 0.0007249688 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162736 E001 4.3210716 0.0036450991 4.199833e-02 9.472311e-02 1 160343316 160343352 37 + 0.856 0.593 -1.082
ENSG00000162736 E002 12.2348051 0.0013777973 8.229953e-02 1.631411e-01 1 160343353 160343382 30 + 1.191 1.049 -0.509
ENSG00000162736 E003 12.5303473 0.0013558215 8.086597e-02 1.608913e-01 1 160343383 160343385 3 + 1.201 1.061 -0.504
ENSG00000162736 E004 12.8291118 0.0013287036 4.821735e-02 1.060206e-01 1 160343386 160343386 1 + 1.221 1.061 -0.573
ENSG00000162736 E005 13.6333241 0.0012702994 2.085553e-02 5.328268e-02 1 160343387 160343390 4 + 1.257 1.072 -0.662
ENSG00000162736 E006 16.0930277 0.0010915874 3.442255e-03 1.155901e-02 1 160343391 160343392 2 + 1.344 1.122 -0.782
ENSG00000162736 E007 22.9496177 0.0008401303 4.184375e-08 4.585097e-07 1 160343393 160343398 6 + 1.555 1.184 -1.287
ENSG00000162736 E008 128.3019631 0.0009478009 2.253769e-05 1.380796e-04 1 160343399 160343481 83 + 2.167 2.047 -0.403
ENSG00000162736 E009 0.9620705 0.0121662673 4.497410e-02 1.001482e-01 1 160343662 160343703 42 + 0.450 0.111 -2.637
ENSG00000162736 E010 2.6260550 0.0085688726 1.152830e-02 3.241464e-02 1 160343704 160343802 99 + 0.729 0.336 -1.899
ENSG00000162736 E011 1.1813507 0.0113538894 9.866393e-01 9.957204e-01 1 160343803 160343888 86 + 0.320 0.336 0.099
ENSG00000162736 E012 0.0000000       1 160344476 160344614 139 +      
ENSG00000162736 E013 218.2350822 0.0002286327 4.824197e-05 2.728881e-04 1 160344722 160344826 105 + 2.374 2.298 -0.253
ENSG00000162736 E014 0.1817044 0.0398871643 6.209131e-01   1 160344827 160345171 345 + 0.000 0.111 9.136
ENSG00000162736 E015 280.3622290 0.0001506215 1.190387e-07 1.192634e-06 1 160348999 160349122 124 + 2.490 2.401 -0.298
ENSG00000162736 E016 0.7708142 0.0142362963 9.570475e-02 1.839420e-01 1 160349486 160349548 63 + 0.390 0.111 -2.316
ENSG00000162736 E017 253.7283118 0.0001810558 2.504185e-08 2.863825e-07 1 160349549 160349655 107 + 2.455 2.353 -0.339
ENSG00000162736 E018 107.4755726 0.0003066809 7.641243e-03 2.287627e-02 1 160349656 160349670 15 + 2.066 1.998 -0.229
ENSG00000162736 E019 269.4543719 0.0007875278 3.909484e-03 1.289033e-02 1 160350105 160350250 146 + 2.450 2.403 -0.158
ENSG00000162736 E020 219.0537397 0.0005993062 2.101275e-02 5.361712e-02 1 160351222 160351287 66 + 2.353 2.317 -0.121
ENSG00000162736 E021 175.6939092 0.0005411026 2.765962e-01 4.160505e-01 1 160351288 160351335 48 + 2.242 2.235 -0.023
ENSG00000162736 E022 169.9710943 0.0038135665 8.739371e-02 1.711883e-01 1 160351336 160351372 37 + 2.249 2.207 -0.143
ENSG00000162736 E023 244.1681606 0.0001803328 3.625573e-01 5.069698e-01 1 160351696 160351805 110 + 2.376 2.379 0.009
ENSG00000162736 E024 119.2968902 0.0004998750 2.168160e-01 3.465729e-01 1 160352054 160352075 22 + 2.077 2.059 -0.060
ENSG00000162736 E025 186.7390282 0.0002052183 1.433046e-02 3.897975e-02 1 160352076 160352125 50 + 2.285 2.244 -0.136
ENSG00000162736 E026 247.9968156 0.0001948942 4.505811e-04 1.968799e-03 1 160352126 160352206 81 + 2.418 2.361 -0.189
ENSG00000162736 E027 320.8297942 0.0001976703 1.257672e-01 2.282379e-01 1 160352887 160352991 105 + 2.500 2.493 -0.024
ENSG00000162736 E028 283.5264432 0.0005658943 8.905409e-02 1.736842e-01 1 160353160 160353237 78 + 2.452 2.436 -0.053
ENSG00000162736 E029 6.2698954 0.0027344579 7.485418e-01 8.357585e-01 1 160353323 160353501 179 + 0.809 0.870 0.236
ENSG00000162736 E030 438.1264099 0.0016830610 8.520371e-01 9.082799e-01 1 160354118 160354290 173 + 2.619 2.640 0.069
ENSG00000162736 E031 226.5287769 0.0012245698 4.015935e-01 5.452875e-01 1 160355655 160355684 30 + 2.315 2.364 0.163
ENSG00000162736 E032 318.6427371 0.0005520810 6.717781e-01 7.779259e-01 1 160355685 160355757 73 + 2.472 2.506 0.113
ENSG00000162736 E033 7.1664638 0.1114915947 4.518490e-01 5.927654e-01 1 160355842 160355862 21 + 0.936 0.855 -0.311
ENSG00000162736 E034 343.8495743 0.0001777611 1.505151e-01 2.623797e-01 1 160355863 160355958 96 + 2.492 2.545 0.176
ENSG00000162736 E035 382.3587116 0.0001359153 2.003493e-01 3.266541e-01 1 160356260 160356347 88 + 2.542 2.590 0.160
ENSG00000162736 E036 510.1455350 0.0001266090 1.560318e-02 4.185273e-02 1 160356600 160356754 155 + 2.658 2.722 0.211
ENSG00000162736 E037 33.1764562 0.0006338336 3.992718e-03 1.312298e-02 1 160356755 160356897 143 + 1.604 1.454 -0.516
ENSG00000162736 E038 31.9490008 0.0034764603 1.710978e-01 2.896105e-01 1 160356898 160357040 143 + 1.541 1.472 -0.236
ENSG00000162736 E039 585.4646593 0.0003990894 3.328963e-05 1.957362e-04 1 160357041 160357253 213 + 2.697 2.793 0.318
ENSG00000162736 E040 1246.5085849 0.0038446417 3.431471e-08 3.820416e-07 1 160358149 160358952 804 + 2.970 3.150 0.601