ENSG00000162688

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361915 ENSG00000162688 HEK293_OSMI2_2hA HEK293_TMG_2hB AGL protein_coding protein_coding 6.602721 1.736868 10.1319 0.03860512 0.198546 2.537485 4.33078222 0.7967849 6.918072 0.04375193 0.4102155 3.102198 0.58810000 0.46000000 0.6818667 0.22186667 0.0086656155 0.0009090496 FALSE TRUE
ENST00000370163 ENSG00000162688 HEK293_OSMI2_2hA HEK293_TMG_2hB AGL protein_coding protein_coding 6.602721 1.736868 10.1319 0.03860512 0.198546 2.537485 0.08077011 0.1324960 0.000000 0.07891070 0.0000000 -3.832849 0.02204167 0.07673333 0.0000000 -0.07673333 0.0009090496 0.0009090496 FALSE TRUE
MSTRG.1675.1 ENSG00000162688 HEK293_OSMI2_2hA HEK293_TMG_2hB AGL protein_coding   6.602721 1.736868 10.1319 0.03860512 0.198546 2.537485 2.00045545 0.7813014 2.950019 0.09015541 0.1593137 1.903307 0.36351250 0.44833333 0.2917667 -0.15656667 0.0693312598 0.0009090496 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162688 E001 38.6283984 0.0043990767 2.655330e-14 8.202450e-13 1 99849999 99850360 362 + 1.285 1.909 2.132
ENSG00000162688 E002 27.6324012 0.0037303156 1.181849e-09 1.726940e-08 1 99850361 99850415 55 + 1.164 1.741 1.992
ENSG00000162688 E003 2.2015959 0.0126226959 1.174013e-03 4.553169e-03 1 99850489 99850618 130 + 0.231 0.865 3.170
ENSG00000162688 E004 1.1739533 0.0130988629 2.400010e-01 3.741408e-01 1 99850619 99850898 280 + 0.287 0.001 -8.795
ENSG00000162688 E005 37.9192952 0.0006068517 1.348557e-10 2.330385e-09 1 99850975 99851034 60 + 1.316 1.837 1.780
ENSG00000162688 E006 58.9189509 0.0038794298 3.455296e-13 9.099186e-12 1 99851035 99851124 90 + 1.497 2.030 1.805
ENSG00000162688 E007 0.9170311 0.0372199825 2.590941e-01 3.964574e-01 1 99852561 99852669 109 + 0.167 0.448 1.943
ENSG00000162688 E008 0.6172225 0.4373995492 5.362100e-01 6.679557e-01 1 99852670 99852703 34 + 0.130 0.280 1.375
ENSG00000162688 E009 0.7019140 0.0162095671 9.463756e-02 1.823362e-01 1 99861210 99861502 293 + 0.092 0.448 2.946
ENSG00000162688 E010 92.3419024 0.0161236229 1.666645e-14 5.323568e-13 1 99861503 99861713 211 + 1.641 2.295 2.198
ENSG00000162688 E011 80.2727007 0.0201915358 4.018143e-12 8.922762e-11 1 99862257 99862423 167 + 1.582 2.232 2.191
ENSG00000162688 E012 70.0130719 0.0003939581 2.786371e-07 2.595229e-06 1 99864386 99864589 204 + 1.618 1.989 1.255
ENSG00000162688 E013 46.0059806 0.0005284899 3.391961e-09 4.558071e-08 1 99870400 99870581 182 + 1.550 1.105 -1.554
ENSG00000162688 E014 34.5315617 0.0014255143 5.551464e-07 4.869696e-06 1 99870758 99870869 112 + 1.430 1.001 -1.521
ENSG00000162688 E015 0.0000000       1 99874470 99874686 217 +      
ENSG00000162688 E016 37.9539557 0.0005385254 4.470232e-07 3.992796e-06 1 99874687 99874810 124 + 1.466 1.073 -1.383
ENSG00000162688 E017 34.1768632 0.0005870854 2.668446e-08 3.034571e-07 1 99875154 99875256 103 + 1.430 0.915 -1.843
ENSG00000162688 E018 29.7709300 0.0056134717 3.256816e-08 3.641586e-07 1 99875358 99875455 98 + 1.378 0.742 -2.342
ENSG00000162688 E019 43.6600512 0.0009304717 6.191757e-09 7.943992e-08 1 99876458 99876597 140 + 1.529 1.073 -1.600
ENSG00000162688 E020 57.1173577 0.0004025469 4.744392e-10 7.456536e-09 1 99877641 99877828 188 + 1.639 1.237 -1.389
ENSG00000162688 E021 41.6205258 0.0188809259 3.005186e-06 2.248069e-05 1 99879923 99880046 124 + 1.509 1.041 -1.648
ENSG00000162688 E022 42.5744317 0.0006646887 1.236907e-10 2.149999e-09 1 99880632 99880795 164 + 1.523 0.960 -1.994
ENSG00000162688 E023 35.1549796 0.0023785808 2.745636e-08 3.114499e-07 1 99881076 99881177 102 + 1.441 0.915 -1.882
ENSG00000162688 E024 47.2035448 0.0057582236 2.685005e-07 2.509205e-06 1 99881292 99881447 156 + 1.559 1.163 -1.377
ENSG00000162688 E025 45.4126531 0.0005559304 2.351160e-06 1.800551e-05 1 99881541 99881691 151 + 1.535 1.237 -1.035
ENSG00000162688 E026 37.6683040 0.0005537696 3.296283e-08 3.682022e-07 1 99884120 99884244 125 + 1.468 1.001 -1.652
ENSG00000162688 E027 33.8343855 0.0007658554 3.155336e-05 1.867561e-04 1 99884339 99884451 113 + 1.413 1.105 -1.082
ENSG00000162688 E028 38.5114630 0.0005568690 1.062868e-05 7.020089e-05 1 99884569 99884703 135 + 1.466 1.163 -1.061
ENSG00000162688 E029 40.7376618 0.0062282735 5.102532e-04 2.197986e-03 1 99887978 99888108 131 + 1.483 1.260 -0.774
ENSG00000162688 E030 43.9654259 0.0024482000 4.057556e-04 1.796933e-03 1 99891220 99891356 137 + 1.512 1.320 -0.665
ENSG00000162688 E031 47.4666692 0.0091625243 1.085237e-02 3.081044e-02 1 99891606 99891739 134 + 1.537 1.422 -0.397
ENSG00000162688 E032 48.1079778 0.0147764561 5.517506e-02 1.182935e-01 1 99892432 99892607 176 + 1.536 1.467 -0.236
ENSG00000162688 E033 35.2123562 0.0017160448 1.829685e-03 6.694766e-03 1 99896286 99896388 103 + 1.417 1.237 -0.626
ENSG00000162688 E034 58.4538629 0.0003936402 1.002995e-11 2.088529e-10 1 99900636 99900861 226 + 1.653 1.189 -1.606
ENSG00000162688 E035 52.6343808 0.0007256102 1.481207e-08 1.769072e-07 1 99902683 99902794 112 + 1.604 1.237 -1.269
ENSG00000162688 E036 57.2660887 0.0004035374 4.820297e-09 6.310053e-08 1 99910712 99910847 136 + 1.638 1.280 -1.233
ENSG00000162688 E037 41.0101139 0.0045576868 5.062758e-05 2.849533e-04 1 99912405 99912517 113 + 1.492 1.214 -0.966
ENSG00000162688 E038 54.0281758 0.0220644493 5.148127e-02 1.117816e-01 1 99913527 99913738 212 + 1.588 1.506 -0.279
ENSG00000162688 E039 35.1421398 0.0074022121 1.979909e-01 3.237060e-01 1 99915389 99915486 98 + 1.397 1.391 -0.020
ENSG00000162688 E040 37.8804073 0.0118139769 7.220794e-03 2.179769e-02 1 99916410 99916497 88 + 1.448 1.282 -0.579
ENSG00000162688 E041 48.3857456 0.0007034219 4.661298e-04 2.030557e-03 1 99916598 99916731 134 + 1.550 1.389 -0.554
ENSG00000162688 E042 304.4195684 0.0104072048 3.273068e-10 5.292079e-09 1 99921534 99924023 2490 + 2.238 2.646 1.362