ENSG00000162676

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000294702 ENSG00000162676 HEK293_OSMI2_2hA HEK293_TMG_2hB GFI1 protein_coding protein_coding 5.149389 6.172061 3.144828 0.3399167 0.3397338 -0.9705267 0.4832994 0.5468630 0.4327896 0.05986506 0.05952104 -0.33070110 0.10072500 0.09003333 0.14010000 0.05006667 3.592980e-01 2.102642e-05 FALSE TRUE
ENST00000427103 ENSG00000162676 HEK293_OSMI2_2hA HEK293_TMG_2hB GFI1 protein_coding protein_coding 5.149389 6.172061 3.144828 0.3399167 0.3397338 -0.9705267 1.2261912 1.3584142 1.3454752 0.23542190 0.03691478 -0.01370634 0.25793333 0.22223333 0.43646667 0.21423333 4.374983e-02 2.102642e-05 FALSE TRUE
ENST00000483490 ENSG00000162676 HEK293_OSMI2_2hA HEK293_TMG_2hB GFI1 protein_coding protein_coding 5.149389 6.172061 3.144828 0.3399167 0.3397338 -0.9705267 0.5176024 0.5693631 0.2037021 0.11580641 0.03965331 -1.43886653 0.10130417 0.09156667 0.06410000 -0.02746667 6.576296e-01 2.102642e-05   FALSE
ENST00000696667 ENSG00000162676 HEK293_OSMI2_2hA HEK293_TMG_2hB GFI1 protein_coding protein_coding 5.149389 6.172061 3.144828 0.3399167 0.3397338 -0.9705267 1.6937147 2.7420044 0.4888268 0.37274127 0.08623850 -2.46387189 0.30705417 0.44156667 0.15280000 -0.28876667 2.102642e-05 2.102642e-05 FALSE FALSE
ENST00000696670 ENSG00000162676 HEK293_OSMI2_2hA HEK293_TMG_2hB GFI1 protein_coding protein_coding 5.149389 6.172061 3.144828 0.3399167 0.3397338 -0.9705267 0.3345180 0.2407056 0.2948286 0.08215091 0.09333494 0.28200391 0.06655833 0.03923333 0.09866667 0.05943333 4.231016e-01 2.102642e-05 FALSE FALSE
ENST00000696671 ENSG00000162676 HEK293_OSMI2_2hA HEK293_TMG_2hB GFI1 protein_coding processed_transcript 5.149389 6.172061 3.144828 0.3399167 0.3397338 -0.9705267 0.4925743 0.5010950 0.2119353 0.27385766 0.21193526 -1.20345256 0.09573750 0.08120000 0.05950000 -0.02170000 7.260656e-01 2.102642e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162676 E001 20.8452116 0.0080883056 0.8510897042 0.9076712715 1 92473043 92474761 1719 - 1.317 1.316 -0.005
ENSG00000162676 E002 160.4596886 0.0041116721 0.0001050922 0.0005455963 1 92474762 92476207 1446 - 2.094 2.216 0.407
ENSG00000162676 E003 26.5550656 0.0007759566 0.4682375518 0.6076576043 1 92478588 92478753 166 - 1.434 1.401 -0.113
ENSG00000162676 E004 17.4589045 0.0011740717 0.1830333923 0.3049897982 1 92480348 92480485 138 - 1.298 1.206 -0.325
ENSG00000162676 E005 26.9855165 0.0182814377 0.0361857964 0.0839409631 1 92480601 92481088 488 - 1.521 1.352 -0.582
ENSG00000162676 E006 15.7815994 0.0040550727 0.0567833518 0.1210891123 1 92482864 92482989 126 - 1.298 1.148 -0.531
ENSG00000162676 E007 10.1383740 0.0145533096 0.2732434166 0.4122544760 1 92482990 92483046 57 - 1.100 0.993 -0.392
ENSG00000162676 E008 20.1242192 0.0009482836 0.3896716917 0.5337368757 1 92483373 92483586 214 - 1.334 1.285 -0.173
ENSG00000162676 E009 0.9158852 0.0154008974 0.4751804368 0.6139190865 1 92483735 92483954 220 - 0.359 0.240 -0.799
ENSG00000162676 E010 5.4989940 0.0031145910 0.7828783822 0.8605893053 1 92484446 92484663 218 - 0.757 0.808 0.202
ENSG00000162676 E011 7.1899161 0.0616604586 0.4398926811 0.5816246895 1 92484664 92484960 297 - 0.789 0.917 0.497
ENSG00000162676 E012 3.8655183 0.0211206365 0.3330152276 0.4766954485 1 92485671 92486013 343 - 0.757 0.623 -0.560
ENSG00000162676 E013 0.8846626 0.0139408898 0.4484558111 0.5897450120 1 92486014 92486097 84 - 0.155 0.298 1.199
ENSG00000162676 E014 4.5276533 0.0040248422 0.0556834996 0.1191554686 1 92486726 92486925 200 - 0.871 0.624 -1.003