ENSG00000162669

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370425 ENSG00000162669 HEK293_OSMI2_2hA HEK293_TMG_2hB HFM1 protein_coding protein_coding 0.9713264 0.4057412 1.908954 0.1189648 0.09675421 2.206562 0.32151779 0.02618465 0.76381488 0.01462315 0.09649089 4.41853893 0.29740833 0.0681000 0.39790000 0.32980000 0.001661164 0.001661164 FALSE TRUE
ENST00000427444 ENSG00000162669 HEK293_OSMI2_2hA HEK293_TMG_2hB HFM1 protein_coding protein_coding 0.9713264 0.4057412 1.908954 0.1189648 0.09675421 2.206562 0.07159160 0.00000000 0.07505428 0.00000000 0.07505428 3.08838391 0.05391250 0.0000000 0.03806667 0.03806667 1.000000000 0.001661164 FALSE FALSE
ENST00000430465 ENSG00000162669 HEK293_OSMI2_2hA HEK293_TMG_2hB HFM1 protein_coding protein_coding 0.9713264 0.4057412 1.908954 0.1189648 0.09675421 2.206562 0.06346153 0.00000000 0.02413436 0.00000000 0.02413436 1.77122463 0.05589583 0.0000000 0.01403333 0.01403333 1.000000000 0.001661164 FALSE TRUE
ENST00000448819 ENSG00000162669 HEK293_OSMI2_2hA HEK293_TMG_2hB HFM1 protein_coding protein_coding 0.9713264 0.4057412 1.908954 0.1189648 0.09675421 2.206562 0.08034212 0.06821137 0.16972235 0.06821137 0.09426078 1.20031953 0.07897917 0.1082000 0.08510000 -0.02310000 1.000000000 0.001661164 FALSE FALSE
ENST00000462405 ENSG00000162669 HEK293_OSMI2_2hA HEK293_TMG_2hB HFM1 protein_coding processed_transcript 0.9713264 0.4057412 1.908954 0.1189648 0.09675421 2.206562 0.20141007 0.19090079 0.34376264 0.10835691 0.15570410 0.81629851 0.28904583 0.4903667 0.17763333 -0.31273333 0.580737450 0.001661164 TRUE TRUE
ENST00000497520 ENSG00000162669 HEK293_OSMI2_2hA HEK293_TMG_2hB HFM1 protein_coding processed_transcript 0.9713264 0.4057412 1.908954 0.1189648 0.09675421 2.206562 0.03189274 0.05994270 0.06416993 0.05994270 0.06416993 0.08466098 0.04572500 0.1659000 0.03253333 -0.13336667 0.774329885 0.001661164   FALSE
MSTRG.1586.4 ENSG00000162669 HEK293_OSMI2_2hA HEK293_TMG_2hB HFM1 protein_coding   0.9713264 0.4057412 1.908954 0.1189648 0.09675421 2.206562 0.13282946 0.05282291 0.33135813 0.05282291 0.19159299 2.44192355 0.12917500 0.1462000 0.18456667 0.03836667 0.878863899 0.001661164 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162669 E001 7.4314995 0.077465585 0.075070852 0.15165386 1 91260766 91261359 594 - 0.739 1.036 1.136
ENSG00000162669 E002 0.3666179 0.026467309 0.165072562 0.28179010 1 91262186 91262240 55 - 0.054 0.257 2.616
ENSG00000162669 E003 3.1944391 0.005467237 0.380880066 0.52516475 1 91262241 91262314 74 - 0.492 0.626 0.614
ENSG00000162669 E004 5.5624299 0.003736180 0.273019475 0.41199799 1 91262315 91262392 78 - 0.683 0.822 0.562
ENSG00000162669 E005 7.3735722 0.002764574 0.000493582 0.00213556 1 91262481 91262592 112 - 0.706 1.117 1.566
ENSG00000162669 E006 1.9293523 0.008393934 0.797810196 0.87099252 1 91266017 91266107 91 - 0.389 0.416 0.152
ENSG00000162669 E007 8.7723093 0.002763331 0.075302369 0.15200862 1 91267745 91267855 111 - 0.832 1.028 0.739
ENSG00000162669 E008 6.8202290 0.069277505 0.292606629 0.43357853 1 91273712 91273815 104 - 0.728 0.928 0.780
ENSG00000162669 E009 7.1688760 0.035324090 0.059417863 0.12564080 1 91274730 91274809 80 - 0.728 1.000 1.053
ENSG00000162669 E010 5.7814186 0.048902142 0.079956222 0.15949234 1 91276628 91276743 116 - 0.658 0.922 1.051
ENSG00000162669 E011 4.0934872 0.004407038 0.365089131 0.50942431 1 91276982 91277062 81 - 0.576 0.701 0.544
ENSG00000162669 E012 5.9767309 0.003038917 0.981408638 0.99241469 1 91313349 91313495 147 - 0.738 0.701 -0.152
ENSG00000162669 E013 5.8074964 0.005424220 0.613227666 0.73198083 1 91313957 91314060 104 - 0.717 0.766 0.198
ENSG00000162669 E014 6.1858694 0.002773184 0.703998566 0.80260946 1 91315815 91315972 158 - 0.738 0.766 0.111
ENSG00000162669 E015 3.9661982 0.004338433 0.366012135 0.51034004 1 91316101 91316139 39 - 0.576 0.701 0.542
ENSG00000162669 E016 4.7109762 0.003752629 0.606542509 0.72665658 1 91316140 91316184 45 - 0.646 0.701 0.234
ENSG00000162669 E017 3.5105061 0.005576089 0.091826018 0.17797315 1 91316391 91316476 86 - 0.510 0.765 1.109
ENSG00000162669 E018 5.3816691 0.003529778 0.240918875 0.37525371 1 91319078 91319209 132 - 0.671 0.822 0.612
ENSG00000162669 E019 6.3332322 0.002596954 0.750623248 0.83724365 1 91319293 91319390 98 - 0.749 0.766 0.069
ENSG00000162669 E020 4.1814170 0.004848190 0.721105079 0.81558435 1 91322950 91322997 48 - 0.632 0.533 -0.447
ENSG00000162669 E021 4.5448007 0.003567357 0.617454894 0.73526006 1 91323093 91323199 107 - 0.658 0.533 -0.557
ENSG00000162669 E022 6.7818882 0.007165000 0.934166623 0.96251673 1 91324675 91324766 92 - 0.787 0.765 -0.088
ENSG00000162669 E023 0.0000000       1 91328838 91328937 100 -      
ENSG00000162669 E024 6.2167158 0.043326091 0.107965824 0.20251289 1 91343430 91343510 81 - 0.796 0.416 -1.709
ENSG00000162669 E025 5.0019644 0.051099061 0.059229323 0.12531766 1 91347429 91347476 48 - 0.727 0.256 -2.433
ENSG00000162669 E026 5.3938395 0.011626811 0.145577619 0.25564742 1 91350738 91350871 134 - 0.738 0.417 -1.474
ENSG00000162669 E027 3.9243440 0.005928710 0.111955627 0.20842619 1 91351549 91351643 95 - 0.632 0.257 -2.030
ENSG00000162669 E028 5.4861480 0.002936281 0.026877999 0.06574107 1 91352506 91352651 146 - 0.759 0.256 -2.557
ENSG00000162669 E029 5.0283675 0.003999201 0.003999975 0.01314227 1 91353051 91353152 102 - 0.738 0.000 -14.746
ENSG00000162669 E030 3.2611517 0.004848101 0.026532743 0.06501725 1 91353256 91353299 44 - 0.590 0.000 -14.118
ENSG00000162669 E031 4.6586265 0.003696718 0.058506909 0.12407740 1 91375358 91375446 89 - 0.694 0.257 -2.294
ENSG00000162669 E032 4.9531246 0.008274158 0.046706993 0.10331115 1 91375527 91375727 201 - 0.717 0.257 -2.386
ENSG00000162669 E033 0.1472490 0.046158102 0.810309033   1 91377443 91377758 316 - 0.054 0.000 -9.659
ENSG00000162669 E034 0.2987644 0.027627547 1.000000000   1 91377759 91378024 266 - 0.101 0.000 -10.659
ENSG00000162669 E035 3.9630658 0.004059470 0.392067041 0.53600962 1 91378025 91378183 159 - 0.619 0.417 -0.972
ENSG00000162669 E036 3.9928168 0.088088709 0.522600102 0.65637528 1 91378403 91378480 78 - 0.620 0.419 -0.968
ENSG00000162669 E037 0.4375944 0.035785394 1.000000000 1.00000000 1 91379059 91379062 4 - 0.144 0.000 -11.243
ENSG00000162669 E038 4.7079574 0.003535549 0.237782349 0.37157501 1 91379063 91379214 152 - 0.683 0.417 -1.245
ENSG00000162669 E039 3.2526189 0.008545807 0.027047023 0.06609025 1 91380104 91380232 129 - 0.590 0.000 -14.118
ENSG00000162669 E040 1.6283858 0.035642883 0.181356046 0.30294823 1 91380233 91380236 4 - 0.389 0.000 -13.118
ENSG00000162669 E041 2.6593564 0.006038980 0.051097949 0.11112920 1 91380912 91380982 71 - 0.527 0.000 -13.828
ENSG00000162669 E042 2.5863036 0.005890847 0.342686132 0.48669960 1 91385187 91385234 48 - 0.492 0.257 -1.386
ENSG00000162669 E043 2.5842273 0.005909486 0.342839059 0.48687253 1 91385575 91385613 39 - 0.492 0.257 -1.386
ENSG00000162669 E044 5.1705309 0.003348607 0.172456510 0.29139644 1 91385614 91385834 221 - 0.717 0.417 -1.386
ENSG00000162669 E045 1.6338101 0.014217391 0.713824583 0.81019894 1 91394093 91394172 80 - 0.365 0.256 -0.710
ENSG00000162669 E046 2.3679789 0.006216774 0.388206174 0.53231010 1 91394173 91394402 230 - 0.473 0.256 -1.295
ENSG00000162669 E047 0.6060617 0.806103467 1.000000000 1.00000000 1 91396293 91396405 113 - 0.186 0.000 -11.677
ENSG00000162669 E048 2.0119556 0.045989721 0.575358209 0.70097742 1 91401012 91401109 98 - 0.412 0.257 -0.969
ENSG00000162669 E049 0.6017953 0.109722030 1.000000000 1.00000000 1 91404581 91404797 217 - 0.184 0.000 -11.662
ENSG00000162669 E050 0.5244761 0.105190165 0.335029941 0.47877631 1 91404798 91404856 59 - 0.102 0.258 1.621