ENSG00000162664

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340281 ENSG00000162664 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF326 protein_coding protein_coding 11.24655 5.85002 19.64806 0.3992872 0.4196495 1.746143 8.724922 5.2586556 14.957157 0.1595791 0.3036749 1.506293 0.8063167 0.90346667 0.7616333 -0.1418333 0.091764108 0.005776555 FALSE TRUE
ENST00000361911 ENSG00000162664 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF326 protein_coding protein_coding 11.24655 5.85002 19.64806 0.3992872 0.4196495 1.746143 2.101767 0.3194791 4.100545 0.1270621 0.4273509 3.641071 0.1531792 0.05233333 0.2081667 0.1558333 0.005776555 0.005776555   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162664 E001 0.8073459 0.0196762825 5.828297e-01 7.070881e-01 1 89995096 89995108 13 + 0.205 0.313 0.807
ENSG00000162664 E002 0.8073459 0.0196762825 5.828297e-01 7.070881e-01 1 89995109 89995109 1 + 0.205 0.313 0.807
ENSG00000162664 E003 0.8073459 0.0196762825 5.828297e-01 7.070881e-01 1 89995110 89995111 2 + 0.205 0.313 0.807
ENSG00000162664 E004 0.8073459 0.0196762825 5.828297e-01 7.070881e-01 1 89995112 89995114 3 + 0.205 0.313 0.807
ENSG00000162664 E005 1.2523272 0.0103540777 5.837119e-01 7.077686e-01 1 89995115 89995118 4 + 0.302 0.412 0.654
ENSG00000162664 E006 2.5862149 0.0059034538 3.074133e-01 4.496424e-01 1 89995119 89995121 3 + 0.581 0.412 -0.832
ENSG00000162664 E007 4.9885354 0.0053506601 7.789203e-02 1.560895e-01 1 89995122 89995122 1 + 0.821 0.560 -1.095
ENSG00000162664 E008 26.5073383 0.0080255369 7.100839e-03 2.149037e-02 1 89995123 89995133 11 + 1.464 1.240 -0.779
ENSG00000162664 E009 32.1104631 0.0039305187 1.588938e-02 4.248989e-02 1 89995134 89995136 3 + 1.531 1.365 -0.571
ENSG00000162664 E010 192.3758867 0.0002438650 3.481201e-16 1.397549e-14 1 89995137 89995273 137 + 2.313 2.084 -0.768
ENSG00000162664 E011 0.9202533 0.0483457097 5.241473e-01 6.577813e-01 1 89997861 89997959 99 + 0.302 0.184 -0.930
ENSG00000162664 E012 191.9455193 0.0002326554 2.737128e-12 6.259544e-11 1 89998110 89998154 45 + 2.304 2.113 -0.639
ENSG00000162664 E013 177.3794845 0.0045481845 1.945224e-05 1.210316e-04 1 90005003 90005038 36 + 2.266 2.093 -0.578
ENSG00000162664 E014 7.7264406 0.0021584482 1.660793e-02 4.407601e-02 1 90005039 90005092 54 + 0.984 0.671 -1.227
ENSG00000162664 E015 267.9479565 0.0012638688 3.722201e-06 2.730003e-05 1 90005133 90005244 112 + 2.430 2.313 -0.391
ENSG00000162664 E016 40.0524229 0.0274048208 4.412994e-06 3.180024e-05 1 90005245 90006449 1205 + 1.684 1.190 -1.709
ENSG00000162664 E017 359.4447958 0.0006000674 8.418378e-06 5.688733e-05 1 90007345 90007608 264 + 2.548 2.463 -0.283
ENSG00000162664 E018 74.3798956 0.0006294840 7.912828e-01 8.665185e-01 1 90007609 90007611 3 + 1.832 1.862 0.100
ENSG00000162664 E019 101.6773746 0.0011124093 3.867829e-01 5.309522e-01 1 90007612 90007633 22 + 1.959 2.012 0.179
ENSG00000162664 E020 100.9930513 0.0024015985 4.476722e-01 5.890491e-01 1 90007634 90007646 13 + 1.956 2.009 0.176
ENSG00000162664 E021 223.0091194 0.0002450217 6.005724e-01 7.217819e-01 1 90007647 90007750 104 + 2.313 2.318 0.014
ENSG00000162664 E022 347.8335381 0.0002278262 5.512347e-02 1.182108e-01 1 90010088 90010286 199 + 2.514 2.492 -0.076
ENSG00000162664 E023 285.7911654 0.0002373023 4.372356e-01 5.792283e-01 1 90013126 90013237 112 + 2.425 2.424 -0.001
ENSG00000162664 E024 309.8678159 0.0001487659 3.791062e-01 5.233894e-01 1 90017317 90017464 148 + 2.447 2.484 0.123
ENSG00000162664 E025 282.0527766 0.0001748365 1.664450e-03 6.168330e-03 1 90018685 90018784 100 + 2.387 2.476 0.296
ENSG00000162664 E026 344.4304203 0.0014570661 4.051214e-07 3.648933e-06 1 90020792 90020922 131 + 2.452 2.603 0.503
ENSG00000162664 E027 393.9658903 0.0003303575 1.297095e-10 2.246373e-09 1 90022250 90022345 96 + 2.513 2.657 0.481
ENSG00000162664 E028 1249.3925101 0.0034521358 1.747930e-03 6.433776e-03 1 90027354 90035533 8180 + 3.033 3.128 0.317