ENSG00000162636

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370035 ENSG00000162636 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM102B protein_coding protein_coding 4.065047 1.200752 7.538662 0.1345276 0.1128383 2.640318 3.7061954 0.3953042 7.28612620 0.05167776 0.08638226 4.170054 0.7532667 0.3424000 0.9666 0.6242000 1.645007e-16 1.645007e-16 FALSE TRUE
MSTRG.1722.3 ENSG00000162636 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM102B protein_coding   4.065047 1.200752 7.538662 0.1345276 0.1128383 2.640318 0.2535687 0.7846693 0.04183964 0.17137314 0.04183964 -3.938227 0.2154917 0.6369667 0.0054 -0.6315667 3.306666e-08 1.645007e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162636 E001 0.6213751 0.0273045138 4.468855e-01 5.883412e-01 1 108560089 108560099 11 + 0.133 0.276 1.307
ENSG00000162636 E002 4.1453113 0.0892875484 1.807855e-01 3.021817e-01 1 108560100 108560355 256 + 0.625 0.276 -1.858
ENSG00000162636 E003 19.6422178 0.0010990436 5.578374e-02 1.193196e-01 1 108560356 108560565 210 + 1.189 0.953 -0.858
ENSG00000162636 E004 25.4086964 0.0007892730 1.050095e-03 4.132817e-03 1 108600566 108600686 121 + 1.306 0.908 -1.440
ENSG00000162636 E005 17.3627605 0.0010517159 3.297635e-02 7.775943e-02 1 108606223 108606252 30 + 1.143 0.858 -1.057
ENSG00000162636 E006 27.6085572 0.0008546304 1.003808e-01 1.910473e-01 1 108612178 108612294 117 + 1.321 1.155 -0.586
ENSG00000162636 E007 21.0201394 0.0008527737 5.755355e-02 1.224229e-01 1 108616382 108616428 47 + 1.218 0.994 -0.810
ENSG00000162636 E008 20.9230274 0.0009047493 2.726577e-02 6.653210e-02 1 108624645 108624664 20 + 1.222 0.953 -0.973
ENSG00000162636 E009 29.2300857 0.0006935427 4.816161e-02 1.059190e-01 1 108624665 108624748 84 + 1.352 1.155 -0.694
ENSG00000162636 E010 6.7251098 0.0439672756 6.087848e-01 7.284170e-01 1 108624749 108628166 3418 + 0.763 0.659 -0.428
ENSG00000162636 E011 37.8450725 0.0006142747 2.134841e-03 7.642174e-03 1 108628167 108628262 96 + 1.469 1.181 -1.004
ENSG00000162636 E012 0.1472490 0.0436868384 7.493993e-01   1 108628263 108628394 132 + 0.049 0.001 -6.544
ENSG00000162636 E013 51.0806932 0.0004750486 2.174101e-04 1.038441e-03 1 108628395 108628584 190 + 1.595 1.292 -1.044
ENSG00000162636 E014 38.4327759 0.0005336620 3.585728e-05 2.090556e-04 1 108628677 108628804 128 + 1.483 1.066 -1.467
ENSG00000162636 E015 30.7579278 0.0007130662 3.562684e-05 2.078784e-04 1 108629588 108629657 70 + 1.392 0.908 -1.739
ENSG00000162636 E016 31.5998203 0.0006723780 1.072743e-06 8.845998e-06 1 108635108 108635190 83 + 1.409 0.801 -2.211
ENSG00000162636 E017 52.9080795 0.0005517813 6.405647e-06 4.450710e-05 1 108635191 108635430 240 + 1.613 1.229 -1.327
ENSG00000162636 E018 410.1791301 0.0002272140 9.694533e-47 4.963784e-44 1 108635431 108639322 3892 + 2.417 2.641 0.745
ENSG00000162636 E019 0.0000000       1 108644696 108644900 205 +