ENSG00000162627

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306121 ENSG00000162627 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX7 protein_coding protein_coding 13.58606 9.709184 17.50196 1.034142 1.126514 0.8494334 10.7686594 7.4241010 14.0508328 0.7894419 0.73803121 0.91945186 0.78198333 0.7663333 0.80436667 0.03803333 0.7718431 0.0286586 FALSE  
ENST00000528824 ENSG00000162627 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX7 protein_coding nonsense_mediated_decay 13.58606 9.709184 17.50196 1.034142 1.126514 0.8494334 1.4707773 1.2693640 1.3170035 0.1741964 0.09823194 0.05274545 0.11283333 0.1303000 0.07580000 -0.05450000 0.0286586 0.0286586 FALSE  
ENST00000529992 ENSG00000162627 HEK293_OSMI2_2hA HEK293_TMG_2hB SNX7 protein_coding protein_coding 13.58606 9.709184 17.50196 1.034142 1.126514 0.8494334 0.4193208 0.6638273 0.2342932 0.3333220 0.12320353 -1.46376526 0.03794167 0.0673000 0.01436667 -0.05293333 0.7113695 0.0286586 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162627 E001 4.8081899 0.0039060978 1.484511e-03 5.586716e-03 1 98661309 98661700 392 + 0.903 0.421 -2.095
ENSG00000162627 E002 7.0515289 0.0024084859 8.425650e-02 1.662273e-01 1 98661701 98661720 20 + 0.980 0.771 -0.800
ENSG00000162627 E003 26.1393094 0.0152429255 2.544449e-01 3.911314e-01 1 98661721 98661809 89 + 1.470 1.365 -0.360
ENSG00000162627 E004 30.4435204 0.0148787597 9.359171e-02 1.807408e-01 1 98661810 98661861 52 + 1.549 1.402 -0.505
ENSG00000162627 E005 49.6743706 0.0049109001 1.777091e-01 2.982420e-01 1 98661862 98661911 50 + 1.733 1.655 -0.265
ENSG00000162627 E006 0.2934659 0.0285280295 7.476212e-01   1 98662223 98662382 160 + 0.100 0.149 0.657
ENSG00000162627 E007 6.9375762 0.0023738430 3.230004e-01 4.663398e-01 1 98662697 98662816 120 + 0.943 0.828 -0.440
ENSG00000162627 E008 1.4780112 0.1793773565 2.931473e-01 4.341887e-01 1 98677301 98677331 31 + 0.250 0.493 1.444
ENSG00000162627 E009 100.2448403 0.0006061851 1.778064e-07 1.721339e-06 1 98684885 98685067 183 + 2.076 1.891 -0.620
ENSG00000162627 E010 95.4326026 0.0047498561 3.367987e-04 1.527581e-03 1 98691075 98691185 111 + 2.049 1.885 -0.550
ENSG00000162627 E011 114.7604251 0.0002586487 9.267684e-02 1.793145e-01 1 98691535 98691699 165 + 2.083 2.035 -0.161
ENSG00000162627 E012 109.0300326 0.0003258329 1.573814e-01 2.716199e-01 1 98695518 98695716 199 + 2.016 2.069 0.175
ENSG00000162627 E013 118.9253369 0.0004648157 3.398001e-01 4.837248e-01 1 98698706 98698905 200 + 2.061 2.098 0.121
ENSG00000162627 E014 119.8706662 0.0002693791 1.998477e-01 3.260472e-01 1 98701817 98701903 87 + 2.060 2.106 0.153
ENSG00000162627 E015 128.7262652 0.0002820595 5.054610e-03 1.608136e-02 1 98738237 98738389 153 + 2.070 2.160 0.300
ENSG00000162627 E016 166.7758800 0.0041401268 1.236611e-06 1.006973e-05 1 98760054 98760500 447 + 2.134 2.320 0.622