ENSG00000162613

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370767 ENSG00000162613 HEK293_OSMI2_2hA HEK293_TMG_2hB FUBP1 protein_coding protein_coding 75.50694 35.89392 102.8915 4.784143 2.515581 1.51905 9.774962 8.476591 10.224033 1.8550968 0.5767940 0.2701177 0.15791667 0.23123333 0.09953333 -0.13170000 2.743887e-07 1.670277e-45 FALSE TRUE
ENST00000370768 ENSG00000162613 HEK293_OSMI2_2hA HEK293_TMG_2hB FUBP1 protein_coding protein_coding 75.50694 35.89392 102.8915 4.784143 2.515581 1.51905 10.705789 4.110786 16.418889 0.6338128 0.8855424 1.9952436 0.13419583 0.11460000 0.15993333 0.04533333 1.223550e-01 1.670277e-45 FALSE TRUE
ENST00000487684 ENSG00000162613 HEK293_OSMI2_2hA HEK293_TMG_2hB FUBP1 protein_coding processed_transcript 75.50694 35.89392 102.8915 4.784143 2.515581 1.51905 6.540639 1.191464 10.222282 0.1310299 0.4279966 3.0902622 0.07680417 0.03513333 0.09943333 0.06430000 5.693655e-04 1.670277e-45 FALSE FALSE
MSTRG.1467.21 ENSG00000162613 HEK293_OSMI2_2hA HEK293_TMG_2hB FUBP1 protein_coding   75.50694 35.89392 102.8915 4.784143 2.515581 1.51905 2.883351 7.052696 0.000000 1.9200292 0.0000000 -9.4640751 0.06906667 0.18986667 0.00000000 -0.18986667 1.670277e-45 1.670277e-45 FALSE TRUE
MSTRG.1467.23 ENSG00000162613 HEK293_OSMI2_2hA HEK293_TMG_2hB FUBP1 protein_coding   75.50694 35.89392 102.8915 4.784143 2.515581 1.51905 31.492904 5.575258 49.755412 1.9599394 2.4207445 3.1554476 0.35062917 0.16866667 0.48300000 0.31433333 1.734452e-02 1.670277e-45 FALSE TRUE
MSTRG.1467.5 ENSG00000162613 HEK293_OSMI2_2hA HEK293_TMG_2hB FUBP1 protein_coding   75.50694 35.89392 102.8915 4.784143 2.515581 1.51905 6.692888 3.224647 9.392099 0.3370504 0.9743988 1.5393747 0.09109167 0.09416667 0.09096667 -0.00320000 1.000000e+00 1.670277e-45 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162613 E001 0.000000       1 77943948 77943978 31 -      
ENSG00000162613 E002 0.000000       1 77943979 77944039 61 -      
ENSG00000162613 E003 1.332650 0.1111400459 2.741231e-04 1.274463e-03 1 77944040 77944054 15 - 0.000 0.688 12.996
ENSG00000162613 E004 1.628192 0.1537039948 2.481684e-03 8.709018e-03 1 77944055 77944061 7 - 0.085 0.725 4.325
ENSG00000162613 E005 8.988687 0.0104641715 3.836783e-03 1.268308e-02 1 77944062 77944063 2 - 0.847 1.181 1.236
ENSG00000162613 E006 15.572878 0.0389933462 2.355301e-03 8.324901e-03 1 77944064 77944090 27 - 1.020 1.434 1.465
ENSG00000162613 E007 115.987584 0.0228191652 4.842984e-04 2.100045e-03 1 77944091 77944269 179 - 1.921 2.222 1.011
ENSG00000162613 E008 426.911680 0.0138317570 9.282859e-01 9.588668e-01 1 77944270 77945505 1236 - 2.611 2.610 -0.002
ENSG00000162613 E009 176.019704 0.0071633827 1.399632e-01 2.479762e-01 1 77945506 77945642 137 - 2.253 2.171 -0.275
ENSG00000162613 E010 165.835315 0.0002373974 2.044059e-20 1.374169e-18 1 77945643 77946481 839 - 2.285 1.978 -1.029
ENSG00000162613 E011 34.387790 0.0009504836 4.794443e-11 8.932236e-10 1 77946482 77946529 48 - 1.646 1.140 -1.756
ENSG00000162613 E012 89.645862 0.0096197735 5.389286e-01 6.702685e-01 1 77946530 77946576 47 - 1.950 1.903 -0.159
ENSG00000162613 E013 272.897291 0.0110022456 1.547229e-10 2.644036e-09 1 77946577 77947452 876 - 2.515 2.124 -1.307
ENSG00000162613 E014 76.268553 0.0012669640 1.406328e-11 2.858021e-10 1 77947453 77947547 95 - 1.960 1.611 -1.177
ENSG00000162613 E015 40.090256 0.0005395133 2.642286e-09 3.623928e-08 1 77947548 77947552 5 - 1.697 1.295 -1.384
ENSG00000162613 E016 66.681533 0.0003816375 3.345138e-10 5.399390e-09 1 77947553 77947692 140 - 1.898 1.573 -1.100
ENSG00000162613 E017 226.447630 0.0003661176 7.213041e-34 1.626773e-31 1 77947693 77948333 641 - 2.430 2.065 -1.218
ENSG00000162613 E018 85.217673 0.0003424401 1.478134e-07 1.452879e-06 1 77948334 77948404 71 - 1.984 1.749 -0.789
ENSG00000162613 E019 128.993210 0.0006381647 9.859091e-11 1.740866e-09 1 77948405 77948484 80 - 2.013 2.227 0.716
ENSG00000162613 E020 564.140327 0.0028433662 2.149033e-15 7.772583e-14 1 77948485 77948774 290 - 2.639 2.870 0.769
ENSG00000162613 E021 42.368810 0.0005413964 2.835085e-13 7.558377e-12 1 77948775 77948914 140 - 1.732 1.224 -1.747
ENSG00000162613 E022 40.392681 0.0005121899 1.315185e-12 3.163100e-11 1 77948970 77949154 185 - 1.712 1.211 -1.727
ENSG00000162613 E023 558.980454 0.0006989860 3.348028e-19 1.951011e-17 1 77949155 77949295 141 - 2.663 2.834 0.569
ENSG00000162613 E024 233.480628 0.0001727529 1.468313e-17 7.045784e-16 1 77949296 77949300 5 - 2.273 2.474 0.672
ENSG00000162613 E025 1.037212 0.0116128100 9.182572e-01 9.523504e-01 1 77951534 77951584 51 - 0.317 0.297 -0.129
ENSG00000162613 E026 1.073845 0.0118658135 3.340936e-01 4.778528e-01 1 77954757 77954790 34 - 0.360 0.174 -1.390
ENSG00000162613 E027 377.385116 0.0003495517 8.991955e-15 2.978145e-13 1 77955255 77955329 75 - 2.500 2.654 0.515
ENSG00000162613 E028 12.266522 0.0033037996 6.806682e-04 2.828359e-03 1 77955330 77955458 129 - 1.206 0.807 -1.475
ENSG00000162613 E029 424.070537 0.0002518012 5.585455e-14 1.645898e-12 1 77956572 77956700 129 - 2.558 2.696 0.461
ENSG00000162613 E030 335.952399 0.0001593962 1.138732e-10 1.990857e-09 1 77960184 77960263 80 - 2.462 2.590 0.427
ENSG00000162613 E031 459.864536 0.0001315118 2.066960e-17 9.685367e-16 1 77960344 77960495 152 - 2.591 2.736 0.481
ENSG00000162613 E032 4.219080 0.0103420833 7.433967e-02 1.504858e-01 1 77960496 77960785 290 - 0.774 0.473 -1.326
ENSG00000162613 E033 550.641688 0.0004307639 1.940148e-08 2.268719e-07 1 77962770 77962930 161 - 2.686 2.782 0.321
ENSG00000162613 E034 578.017009 0.0008187823 5.503476e-02 1.180566e-01 1 77963574 77963715 142 - 2.731 2.763 0.109
ENSG00000162613 E035 532.996190 0.0004504898 4.194744e-01 5.627261e-01 1 77964062 77964162 101 - 2.714 2.694 -0.068
ENSG00000162613 E036 504.424800 0.0001098278 7.477430e-02 1.511643e-01 1 77964254 77964356 103 - 2.696 2.662 -0.113
ENSG00000162613 E037 571.008187 0.0013586981 3.030598e-02 7.256727e-02 1 77964646 77964747 102 - 2.757 2.700 -0.189
ENSG00000162613 E038 591.651728 0.0021624729 2.961929e-03 1.015011e-02 1 77964870 77964968 99 - 2.782 2.693 -0.294
ENSG00000162613 E039 641.710173 0.0043156783 2.380408e-02 5.941127e-02 1 77965069 77965231 163 - 2.816 2.727 -0.296
ENSG00000162613 E040 374.641011 0.0035481270 1.100704e-01 2.056424e-01 1 77966694 77966751 58 - 2.576 2.511 -0.217
ENSG00000162613 E041 424.838703 0.0048307230 4.429189e-02 9.891741e-02 1 77966884 77966955 72 - 2.638 2.548 -0.298
ENSG00000162613 E042 336.198744 0.0010144434 4.403279e-04 1.929294e-03 1 77967049 77967098 50 - 2.540 2.442 -0.326
ENSG00000162613 E043 71.186140 0.0003805145 2.735107e-01 4.125624e-01 1 77967099 77967101 3 - 1.856 1.803 -0.179
ENSG00000162613 E044 337.492913 0.0013286754 1.342241e-03 5.117296e-03 1 77967627 77967666 40 - 2.540 2.445 -0.319
ENSG00000162613 E045 301.336048 0.0002022971 5.235867e-06 3.708565e-05 1 77968165 77968203 39 - 2.497 2.388 -0.361
ENSG00000162613 E046 11.729309 0.0028763362 4.405280e-02 9.847981e-02 1 77969022 77969084 63 - 1.150 0.924 -0.829
ENSG00000162613 E047 364.052267 0.0029434842 5.598948e-03 1.755057e-02 1 77969925 77970015 91 - 2.575 2.473 -0.340
ENSG00000162613 E048 268.590579 0.0023765014 9.127373e-05 4.810018e-04 1 77978885 77979059 175 - 2.454 2.312 -0.475
ENSG00000162613 E049 30.326540 0.0006670617 7.001800e-04 2.899642e-03 1 77979060 77979193 134 - 1.544 1.295 -0.861
ENSG00000162613 E050 1.741304 0.0082259899 3.685758e-01 5.129881e-01 1 77979397 77980037 641 - 0.468 0.298 -0.974