ENSG00000162607

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339950 ENSG00000162607 HEK293_OSMI2_2hA HEK293_TMG_2hB USP1 protein_coding protein_coding 58.27302 15.24916 106.3285 1.008734 4.225068 2.800917 40.2911959 7.101637 76.330806 1.8710318 3.51774737 3.424201 0.63545833 0.4680333 0.71773333 0.24970000 0.2154139007 2.600382e-09 FALSE TRUE
MSTRG.1318.10 ENSG00000162607 HEK293_OSMI2_2hA HEK293_TMG_2hB USP1 protein_coding   58.27302 15.24916 106.3285 1.008734 4.225068 2.800917 0.8051752 2.374268 0.000000 1.5211171 0.00000000 -7.897403 0.04997500 0.1524667 0.00000000 -0.15246667 0.0506728954 2.600382e-09 FALSE TRUE
MSTRG.1318.15 ENSG00000162607 HEK293_OSMI2_2hA HEK293_TMG_2hB USP1 protein_coding   58.27302 15.24916 106.3285 1.008734 4.225068 2.800917 1.3094861 2.420191 1.147976 1.1106421 0.09580014 -1.069464 0.05121667 0.1576333 0.01076667 -0.14686667 0.0001688254 2.600382e-09 FALSE TRUE
MSTRG.1318.4 ENSG00000162607 HEK293_OSMI2_2hA HEK293_TMG_2hB USP1 protein_coding   58.27302 15.24916 106.3285 1.008734 4.225068 2.800917 9.4004230 2.891340 17.713164 0.5340981 0.83948417 2.610845 0.16140833 0.1915667 0.16753333 -0.02403333 0.8877489438 2.600382e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162607 E001 0.000000       1 62436297 62436297 1 +      
ENSG00000162607 E002 0.000000       1 62436298 62436303 6 +      
ENSG00000162607 E003 2.344798 0.1179598909 5.188564e-01 6.529918e-01 1 62436304 62436467 164 + 0.412 0.299 -0.674
ENSG00000162607 E004 3.090722 0.0130681789 3.872067e-02 8.866491e-02 1 62436468 62436562 95 + 0.508 0.001 -10.033
ENSG00000162607 E005 43.554105 0.0005053896 3.347265e-02 7.872201e-02 1 62436894 62436922 29 + 1.460 1.398 -0.216
ENSG00000162607 E006 36.759754 0.0050659026 9.491297e-02 1.827502e-01 1 62436923 62436932 10 + 1.388 1.343 -0.153
ENSG00000162607 E007 67.252554 0.0039762410 2.105610e-04 1.009060e-03 1 62436933 62437027 95 + 1.656 1.478 -0.608
ENSG00000162607 E008 47.964991 0.0080195283 3.036858e-05 1.804767e-04 1 62437028 62437036 9 + 1.525 1.204 -1.117
ENSG00000162607 E009 43.099848 0.0187309155 2.218273e-02 5.605286e-02 1 62437037 62437038 2 + 1.467 1.322 -0.502
ENSG00000162607 E010 44.488353 0.0120190873 8.623662e-03 2.534604e-02 1 62437039 62437043 5 + 1.482 1.322 -0.551
ENSG00000162607 E011 56.020138 0.0071331983 5.270363e-02 1.139658e-01 1 62437044 62437048 5 + 1.567 1.520 -0.162
ENSG00000162607 E012 78.155447 0.0024901385 2.387983e-02 5.955639e-02 1 62437049 62437066 18 + 1.706 1.673 -0.112
ENSG00000162607 E013 329.818950 0.0072584027 2.629820e-05 1.585903e-04 1 62437067 62437400 334 + 2.331 2.237 -0.316
ENSG00000162607 E014 319.340836 0.0001710319 7.630181e-15 2.556623e-13 1 62439799 62439988 190 + 2.321 2.182 -0.466
ENSG00000162607 E015 182.559213 0.0004213487 4.406144e-05 2.516144e-04 1 62439989 62440037 49 + 2.071 2.017 -0.181
ENSG00000162607 E016 315.827922 0.0177775059 2.102130e-02 5.363316e-02 1 62441488 62441608 121 + 2.306 2.277 -0.098
ENSG00000162607 E017 296.625240 0.0002261982 5.723038e-06 4.020068e-05 1 62442195 62442299 105 + 2.278 2.250 -0.093
ENSG00000162607 E018 397.640176 0.0135175490 3.449834e-03 1.158138e-02 1 62443159 62443319 161 + 2.408 2.358 -0.167
ENSG00000162607 E019 4.545281 0.0650993539 1.188556e-01 2.183112e-01 1 62443320 62443320 1 + 0.611 0.302 -1.619
ENSG00000162607 E020 10.326717 0.0023077504 3.664118e-01 5.107582e-01 1 62444680 62444737 58 + 0.879 0.845 -0.132
ENSG00000162607 E021 979.252555 0.0030553062 2.629795e-07 2.462591e-06 1 62444738 62445250 513 + 2.797 2.767 -0.100
ENSG00000162607 E022 576.177125 0.0012358670 1.739800e-04 8.525606e-04 1 62445251 62445429 179 + 2.561 2.579 0.060
ENSG00000162607 E023 599.298001 0.0017461306 1.960568e-01 3.212925e-01 1 62447341 62447511 171 + 2.570 2.655 0.284
ENSG00000162607 E024 640.840663 0.0001090267 2.900532e-01 4.308294e-01 1 62448465 62448666 202 + 2.596 2.696 0.332
ENSG00000162607 E025 7.529776 0.0108834668 3.152739e-01 4.580266e-01 1 62448907 62448985 79 + 0.777 0.698 -0.321
ENSG00000162607 E026 2499.007057 0.0306422983 1.965829e-04 9.493254e-04 1 62450246 62451804 1559 + 3.148 3.477 1.093