ENSG00000162604

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371180 ENSG00000162604 HEK293_OSMI2_2hA HEK293_TMG_2hB TM2D1 protein_coding protein_coding 28.26384 15.40999 40.21402 4.241357 0.9599122 1.383255 1.371087 3.1248641 3.177342 3.1248641 3.1773419 0.02395089 0.07446250 0.23890000 0.08106667 -0.157833333 9.445469e-01 5.731558e-34 FALSE TRUE
ENST00000472989 ENSG00000162604 HEK293_OSMI2_2hA HEK293_TMG_2hB TM2D1 protein_coding processed_transcript 28.26384 15.40999 40.21402 4.241357 0.9599122 1.383255 2.380081 1.0605732 2.040573 0.5811417 1.0469927 0.93764385 0.07734167 0.05826667 0.05050000 -0.007766667 9.922858e-01 5.731558e-34 FALSE FALSE
ENST00000606498 ENSG00000162604 HEK293_OSMI2_2hA HEK293_TMG_2hB TM2D1 protein_coding protein_coding 28.26384 15.40999 40.21402 4.241357 0.9599122 1.383255 5.228767 7.9980177 3.568231 4.9769282 3.5682309 -1.16219867 0.29014583 0.48213333 0.08470000 -0.397433333 3.173598e-01 5.731558e-34 FALSE TRUE
MSTRG.1309.1 ENSG00000162604 HEK293_OSMI2_2hA HEK293_TMG_2hB TM2D1 protein_coding   28.26384 15.40999 40.21402 4.241357 0.9599122 1.383255 12.701743 0.0000000 21.611662 0.0000000 1.7212883 11.07826172 0.30453750 0.00000000 0.53846667 0.538466667 5.731558e-34 5.731558e-34 TRUE TRUE
MSTRG.1309.5 ENSG00000162604 HEK293_OSMI2_2hA HEK293_TMG_2hB TM2D1 protein_coding   28.26384 15.40999 40.21402 4.241357 0.9599122 1.383255 1.535038 0.8424193 1.930846 0.2933571 0.4226994 1.18705062 0.06434167 0.05676667 0.04826667 -0.008500000 9.005933e-01 5.731558e-34 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162604 E001 0.6266857 0.0170394154 5.758600e-01 7.013768e-01 1 61673871 61673917 47 - 0.174 0.270 0.813
ENSG00000162604 E002 1.8402900 0.2253990751 5.217904e-01 6.556647e-01 1 61681046 61681046 1 - 0.392 0.545 0.772
ENSG00000162604 E003 1.8402900 0.2253990751 5.217904e-01 6.556647e-01 1 61681047 61681047 1 - 0.392 0.545 0.772
ENSG00000162604 E004 2.5850799 0.2182216645 6.755133e-01 7.807772e-01 1 61681048 61681048 1 - 0.506 0.633 0.582
ENSG00000162604 E005 8.8140160 0.0024251154 4.660172e-03 1.498601e-02 1 61681049 61681086 38 - 0.853 1.157 1.124
ENSG00000162604 E006 9.8489488 0.0022287975 2.479723e-03 8.703264e-03 1 61681087 61681099 13 - 0.896 1.206 1.135
ENSG00000162604 E007 73.4265357 0.0003954171 3.219445e-29 5.053142e-27 1 61681100 61681244 145 - 1.633 2.094 1.555
ENSG00000162604 E008 62.8601220 0.0055145191 3.848791e-15 1.347767e-13 1 61681245 61681312 68 - 1.574 2.018 1.500
ENSG00000162604 E009 94.7240426 0.0005544052 2.939642e-21 2.168638e-19 1 61681313 61681350 38 - 1.811 2.158 1.165
ENSG00000162604 E010 9.7275028 0.0321446439 7.957646e-01 8.696028e-01 1 61683272 61683416 145 - 1.044 0.985 -0.217
ENSG00000162604 E011 109.2891115 0.0002832614 9.925587e-08 1.008297e-06 1 61683417 61683451 35 - 1.966 2.144 0.597
ENSG00000162604 E012 141.1159625 0.0003067327 1.721272e-04 8.443766e-04 1 61683452 61683496 45 - 2.109 2.221 0.375
ENSG00000162604 E013 168.6741723 0.0002943059 8.063607e-01 8.769176e-01 1 61683497 61683546 50 - 2.230 2.238 0.027
ENSG00000162604 E014 1.9552749 0.0072540314 3.120718e-01 4.545956e-01 1 61683547 61683857 311 - 0.538 0.361 -0.922
ENSG00000162604 E015 14.6051668 0.0012017612 5.468635e-01 6.769624e-01 1 61686792 61686895 104 - 1.175 1.229 0.191
ENSG00000162604 E016 9.4482721 0.0020348252 8.923777e-01 9.352245e-01 1 61686896 61686921 26 - 1.034 1.021 -0.048
ENSG00000162604 E017 0.6172225 0.5179741057 9.679284e-01 9.839495e-01 1 61694154 61694696 543 - 0.238 0.157 -0.751
ENSG00000162604 E018 119.0998431 0.0002981644 1.231009e-01 2.243751e-01 1 61694697 61694697 1 - 2.101 2.050 -0.169
ENSG00000162604 E019 210.6806546 0.0002193238 9.987689e-01 1.000000e+00 1 61694698 61694770 73 - 2.328 2.328 0.003
ENSG00000162604 E020 2.6906887 0.0065232725 1.000961e-01 1.906261e-01 1 61696065 61696241 177 - 0.647 0.361 -1.404
ENSG00000162604 E021 21.9262865 0.0008867627 4.405778e-05 2.516011e-04 1 61697509 61700274 2766 - 1.462 1.131 -1.159
ENSG00000162604 E022 247.4898584 0.0002094716 2.376641e-01 3.714454e-01 1 61700934 61701025 92 - 2.406 2.379 -0.089
ENSG00000162604 E023 265.5671146 0.0003146049 5.035650e-05 2.835994e-04 1 61709329 61709437 109 - 2.459 2.366 -0.310
ENSG00000162604 E024 179.7816447 0.0002042051 1.135075e-09 1.665822e-08 1 61723713 61723772 60 - 2.316 2.150 -0.555
ENSG00000162604 E025 94.8307719 0.0003783058 1.388747e-04 6.986663e-04 1 61723773 61723784 12 - 2.033 1.888 -0.486
ENSG00000162604 E026 83.7703129 0.0003668505 2.388046e-04 1.128228e-03 1 61723785 61723786 2 - 1.982 1.834 -0.496
ENSG00000162604 E027 4.7134878 0.0712322981 6.918505e-01 7.932230e-01 1 61724288 61724425 138 - 0.788 0.689 -0.403
ENSG00000162604 E028 21.5747659 0.0044692560 1.117599e-01 2.081425e-01 1 61724902 61724919 18 - 1.403 1.270 -0.461
ENSG00000162604 E029 31.9373734 0.0062244848 1.872186e-01 3.102411e-01 1 61724920 61724954 35 - 1.554 1.448 -0.364
ENSG00000162604 E030 21.5252922 0.0009362346 1.575446e-01 2.718469e-01 1 61724955 61724956 2 - 1.390 1.282 -0.377
ENSG00000162604 E031 214.9539805 0.0019350922 1.546297e-08 1.839737e-07 1 61724957 61725423 467 - 2.398 2.209 -0.633