ENSG00000162601

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000472487 ENSG00000162601 HEK293_OSMI2_2hA HEK293_TMG_2hB MYSM1 protein_coding protein_coding 11.46565 5.537213 19.41562 0.3501317 1.977761 1.808126 1.4494718 0.03240147 2.6765951 0.03240147 0.2417662 5.9855207 0.10119583 0.005233333 0.14256667 0.13733333 1.077903e-06 5.396535e-19 FALSE TRUE
ENST00000483003 ENSG00000162601 HEK293_OSMI2_2hA HEK293_TMG_2hB MYSM1 protein_coding processed_transcript 11.46565 5.537213 19.41562 0.3501317 1.977761 1.808126 2.8018439 3.45023012 4.7570970 0.47178692 1.4723606 0.4622430 0.32915833 0.618100000 0.23456667 -0.38353333 1.826813e-03 5.396535e-19 FALSE FALSE
ENST00000493821 ENSG00000162601 HEK293_OSMI2_2hA HEK293_TMG_2hB MYSM1 protein_coding processed_transcript 11.46565 5.537213 19.41562 0.3501317 1.977761 1.808126 1.3401688 0.24816594 2.9992274 0.14211893 0.2498460 3.5430225 0.09864583 0.047933333 0.15526667 0.10733333 5.958336e-02 5.396535e-19 FALSE TRUE
ENST00000622766 ENSG00000162601 HEK293_OSMI2_2hA HEK293_TMG_2hB MYSM1 protein_coding protein_coding 11.46565 5.537213 19.41562 0.3501317 1.977761 1.808126 1.4953841 1.44252573 1.9290395 0.15335393 0.2879498 0.4167785 0.17587083 0.261866667 0.09996667 -0.16190000 3.964801e-04 5.396535e-19 FALSE TRUE
ENST00000665648 ENSG00000162601 HEK293_OSMI2_2hA HEK293_TMG_2hB MYSM1 protein_coding nonsense_mediated_decay 11.46565 5.537213 19.41562 0.3501317 1.977761 1.808126 1.3842546 0.00000000 2.7316883 0.00000000 0.2662373 8.0989208 0.08380833 0.000000000 0.14083333 0.14083333 5.396535e-19 5.396535e-19 TRUE TRUE
MSTRG.1285.14 ENSG00000162601 HEK293_OSMI2_2hA HEK293_TMG_2hB MYSM1 protein_coding   11.46565 5.537213 19.41562 0.3501317 1.977761 1.808126 0.8887645 0.02672377 1.8175125 0.02672377 0.1118788 5.6370234 0.05882500 0.005366667 0.09526667 0.08990000 1.488611e-08 5.396535e-19 FALSE TRUE
MSTRG.1285.8 ENSG00000162601 HEK293_OSMI2_2hA HEK293_TMG_2hB MYSM1 protein_coding   11.46565 5.537213 19.41562 0.3501317 1.977761 1.808126 0.8949838 0.00000000 0.9525749 0.00000000 0.4990259 6.5888269 0.05180417 0.000000000 0.05173333 0.05173333 3.656626e-01 5.396535e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162601 E001 0.6976476 0.1001981077 8.050812e-02 1.603518e-01 1 58643440 58645384 1945 - 0.088 0.463 3.085
ENSG00000162601 E002 0.3697384 0.0274424043 6.726532e-03 2.051221e-02 1 58646427 58646569 143 - 0.000 0.461 13.107
ENSG00000162601 E003 0.0000000       1 58654739 58654742 4 -      
ENSG00000162601 E004 0.0000000       1 58654743 58654750 8 -      
ENSG00000162601 E005 92.6659133 0.0121177996 2.593899e-37 7.536909e-35 1 58654751 58655397 647 - 1.529 2.421 3.002
ENSG00000162601 E006 213.1332222 0.0108850237 7.908199e-12 1.673388e-10 1 58655398 58656243 846 - 2.063 2.517 1.517
ENSG00000162601 E007 473.8661892 0.0003234651 5.585755e-01 6.867935e-01 1 58656244 58658967 2724 - 2.487 2.564 0.258
ENSG00000162601 E008 32.6352733 0.0007590404 3.694598e-01 5.138726e-01 1 58658968 58659143 176 - 1.351 1.356 0.019
ENSG00000162601 E009 20.3978429 0.0009571770 1.681534e-01 2.857951e-01 1 58659144 58659152 9 - 1.167 1.091 -0.272
ENSG00000162601 E010 33.4811941 0.0006308751 2.935551e-02 7.068920e-02 1 58659153 58659212 60 - 1.376 1.255 -0.422
ENSG00000162601 E011 90.5749817 0.0487372729 1.331017e-02 3.664169e-02 1 58659213 58659665 453 - 1.806 1.596 -0.711
ENSG00000162601 E012 42.5816617 0.0005356275 4.180407e-04 1.843581e-03 1 58659666 58659768 103 - 1.488 1.255 -0.807
ENSG00000162601 E013 33.1742691 0.0005985833 9.015049e-05 4.757044e-04 1 58659769 58659805 37 - 1.392 1.056 -1.189
ENSG00000162601 E014 33.4842855 0.0053726373 7.434181e-05 4.009860e-04 1 58659806 58659908 103 - 1.396 1.019 -1.339
ENSG00000162601 E015 60.8689162 0.0141370449 3.720586e-04 1.666203e-03 1 58659909 58660155 247 - 1.640 1.377 -0.901
ENSG00000162601 E016 36.3901745 0.0076555112 1.927557e-03 7.000955e-03 1 58661170 58661227 58 - 1.426 1.180 -0.861
ENSG00000162601 E017 44.8781730 0.0004589326 2.752893e-04 1.279099e-03 1 58661406 58661511 106 - 1.511 1.277 -0.808
ENSG00000162601 E018 13.2642088 0.0177687908 1.947345e-01 3.196674e-01 1 58661512 58663449 1938 - 1.004 0.882 -0.458
ENSG00000162601 E019 2.6539441 0.0452557382 3.341744e-01 4.779251e-01 1 58663450 58663522 73 - 0.463 0.288 -1.017
ENSG00000162601 E020 52.2198979 0.0004322215 1.554880e-03 5.813449e-03 1 58665499 58665631 133 - 1.568 1.407 -0.553
ENSG00000162601 E021 59.0260433 0.0004400160 7.689499e-07 6.547202e-06 1 58667038 58667226 189 - 1.632 1.319 -1.078
ENSG00000162601 E022 30.3172595 0.0007134906 5.890995e-04 2.493590e-03 1 58667847 58667921 75 - 1.349 1.056 -1.037
ENSG00000162601 E023 6.3198970 0.0485357785 1.247401e-01 2.267650e-01 1 58668430 58668566 137 - 0.740 0.461 -1.251
ENSG00000162601 E024 18.1085680 0.0011085456 6.987180e-02 1.431633e-01 1 58668632 58668682 51 - 1.125 0.978 -0.538
ENSG00000162601 E025 28.8849285 0.0024484227 3.792167e-03 1.255992e-02 1 58668984 58669038 55 - 1.326 1.091 -0.834
ENSG00000162601 E026 35.5874012 0.0005655275 2.050260e-05 1.268710e-04 1 58671870 58671958 89 - 1.423 1.056 -1.294
ENSG00000162601 E027 38.6803661 0.0069253709 8.488768e-04 3.433843e-03 1 58673573 58673650 78 - 1.448 1.182 -0.928
ENSG00000162601 E028 45.1666180 0.0004732426 1.671520e-05 1.055197e-04 1 58675477 58675580 104 - 1.517 1.207 -1.077
ENSG00000162601 E029 2.3074978 0.0536980791 9.389856e-01 9.656857e-01 1 58676772 58676925 154 - 0.391 0.461 0.371
ENSG00000162601 E030 49.7337803 0.0004714423 1.480859e-04 7.387799e-04 1 58676926 58677056 131 - 1.551 1.319 -0.801
ENSG00000162601 E031 124.6162022 0.0004214176 1.970021e-11 3.908416e-10 1 58681785 58682545 761 - 1.948 1.666 -0.953
ENSG00000162601 E032 29.9365387 0.0008212490 2.466777e-08 2.824560e-07 1 58685153 58685251 99 - 1.366 0.679 -2.557
ENSG00000162601 E033 27.0923799 0.0007613112 3.361687e-05 1.974948e-04 1 58689038 58689116 79 - 1.315 0.881 -1.571
ENSG00000162601 E034 14.5403516 0.0011790631 8.278128e-04 3.358748e-03 1 58689117 58689293 177 - 1.062 0.583 -1.896
ENSG00000162601 E035 14.6238973 0.0011923938 1.228967e-02 3.422876e-02 1 58689294 58689367 74 - 1.054 0.757 -1.128
ENSG00000162601 E036 18.2568638 0.0009866240 1.127184e-02 3.181207e-02 1 58689368 58689662 295 - 1.140 0.881 -0.952
ENSG00000162601 E037 4.1086327 0.0477253162 1.304653e-06 1.056973e-05 1 58690188 58690225 38 - 0.327 1.180 3.656
ENSG00000162601 E038 14.6039416 0.0312219144 3.364210e-02 7.904201e-02 1 58690226 58690249 24 - 0.968 1.333 1.307
ENSG00000162601 E039 29.8842204 0.0161847236 1.815154e-02 4.745727e-02 1 58690340 58690417 78 - 1.268 1.584 1.095
ENSG00000162601 E040 0.5944058 0.2715913027 5.273025e-02 1.140091e-01 1 58691712 58691804 93 - 0.046 0.470 4.119
ENSG00000162601 E041 1.3392975 0.2596202507 4.146517e-01 5.580544e-01 1 58692406 58692860 455 - 0.224 0.470 1.531
ENSG00000162601 E042 43.0839943 0.0142723603 1.525456e-02 4.106207e-02 1 58692861 58692931 71 - 1.423 1.720 1.013
ENSG00000162601 E043 42.7266956 0.0096608847 1.199567e-03 4.638981e-03 1 58695129 58695207 79 - 1.408 1.751 1.172
ENSG00000162601 E044 26.0210129 0.0117980064 9.866395e-02 1.884499e-01 1 58699985 58700091 107 - 1.221 1.467 0.859