ENSG00000162585

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378546 ENSG00000162585 HEK293_OSMI2_2hA HEK293_TMG_2hB FAAP20 protein_coding protein_coding 99.28221 206.0837 43.69282 11.90502 1.154839 -2.237502 71.883238 158.186530 27.619460 11.868769 1.3170158 -2.5174387 0.6643167 0.76613333 0.63156667 -0.13456667 2.379420e-03 1.94585e-09 FALSE TRUE
ENST00000400919 ENSG00000162585 HEK293_OSMI2_2hA HEK293_TMG_2hB FAAP20 protein_coding protein_coding 99.28221 206.0837 43.69282 11.90502 1.154839 -2.237502 5.352337 8.391515 4.202465 1.116668 0.1056214 -0.9959849 0.0668625 0.04043333 0.09623333 0.05580000 1.945850e-09 1.94585e-09 FALSE TRUE
ENST00000476803 ENSG00000162585 HEK293_OSMI2_2hA HEK293_TMG_2hB FAAP20 protein_coding processed_transcript 99.28221 206.0837 43.69282 11.90502 1.154839 -2.237502 9.374367 15.330691 6.042414 2.080201 0.5007449 -1.3417810 0.1279792 0.07590000 0.13806667 0.06216667 4.882688e-02 1.94585e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162585 E001 1.0725974 0.0545836045 1.400962e-01 2.481587e-01 1 2184461 2184463 3 - 0.488 0.206 -1.778
ENSG00000162585 E002 3.6856616 0.0678113123 3.936780e-02 8.985244e-02 1 2184464 2184477 14 - 0.859 0.493 -1.563
ENSG00000162585 E003 175.8734919 0.0002351337 1.138226e-24 1.205330e-22 1 2184478 2185174 697 - 2.348 2.037 -1.040
ENSG00000162585 E004 48.0271981 0.0004581403 2.205730e-08 2.552339e-07 1 2185175 2185223 49 - 1.802 1.484 -1.080
ENSG00000162585 E005 70.3485834 0.0020603186 2.862524e-10 4.674971e-09 1 2185224 2185364 141 - 1.963 1.642 -1.081
ENSG00000162585 E006 40.4195926 0.0216804046 1.938776e-05 1.206700e-04 1 2185365 2185397 33 - 1.767 1.391 -1.283
ENSG00000162585 E007 54.8416530 0.0117193374 7.277679e-08 7.590061e-07 1 2185398 2185513 116 - 1.899 1.519 -1.291
ENSG00000162585 E008 12.4737828 0.0016744612 4.562640e-03 1.471809e-02 1 2186004 2186249 246 - 1.229 0.929 -1.088
ENSG00000162585 E009 24.7493137 0.0109986845 4.280227e-09 5.642055e-08 1 2186838 2187206 369 - 1.656 1.150 -1.756
ENSG00000162585 E010 4.6298735 0.0035779845 8.740301e-03 2.563750e-02 1 2189544 2189546 3 - 0.936 0.556 -1.553
ENSG00000162585 E011 4.4481691 0.0036999055 6.210398e-03 1.916847e-02 1 2189547 2189547 1 - 0.936 0.537 -1.640
ENSG00000162585 E012 32.0799434 0.0006402823 1.838798e-01 3.060926e-01 1 2189548 2189568 21 - 1.279 1.398 0.414
ENSG00000162585 E013 57.8388088 0.0004685849 1.773289e-04 8.668634e-04 1 2189569 2189579 11 - 1.390 1.661 0.927
ENSG00000162585 E014 461.9397642 0.0003037359 9.482357e-15 3.127509e-13 1 2189580 2189712 133 - 2.346 2.546 0.665
ENSG00000162585 E015 626.6041134 0.0008766177 1.361496e-10 2.350815e-09 1 2189713 2189781 69 - 2.517 2.676 0.531
ENSG00000162585 E016 195.2250403 0.0003476018 1.053077e-23 1.011162e-21 1 2189782 2191900 2119 - 2.380 2.086 -0.985
ENSG00000162585 E017 148.1361539 0.0003546227 1.828903e-03 6.692554e-03 1 2191901 2192646 746 - 2.123 2.013 -0.366
ENSG00000162585 E018 52.9689288 0.0005057657 3.136257e-02 7.461065e-02 1 2192647 2192844 198 - 1.695 1.571 -0.421
ENSG00000162585 E019 114.6060597 0.0003014072 2.066613e-02 5.288223e-02 1 2192845 2192975 131 - 1.997 1.906 -0.308
ENSG00000162585 E020 35.1064767 0.0046033598 2.736486e-11 5.305691e-10 1 2192976 2193638 663 - 1.762 1.299 -1.586
ENSG00000162585 E021 1633.6385554 0.0001623087 9.935792e-13 2.441066e-11 1 2193639 2193910 272 - 2.995 3.082 0.289
ENSG00000162585 E022 963.4903086 0.0008501961 4.449041e-02 9.927064e-02 1 2193998 2194133 136 - 2.803 2.848 0.150
ENSG00000162585 E023 51.9072433 0.0005105921 1.917069e-06 1.497106e-05 1 2194134 2194213 80 - 1.797 1.532 -0.902
ENSG00000162585 E024 504.9274348 0.0054193523 1.740510e-01 2.934442e-01 1 2194688 2194793 106 - 2.504 2.571 0.223
ENSG00000162585 E025 4.0168011 0.0041195216 9.506801e-01 9.731326e-01 1 2198007 2198062 56 - 0.577 0.592 0.067
ENSG00000162585 E026 4.3113983 0.0044822390 8.748542e-01 9.235864e-01 1 2198063 2198142 80 - 0.577 0.608 0.143
ENSG00000162585 E027 0.2955422 0.0298778770 2.683062e-01   1 2198143 2198753 611 - 0.229 0.062 -2.183
ENSG00000162585 E028 6.5504073 0.0043636123 7.363849e-01 8.268928e-01 1 2198754 2201049 2296 - 0.712 0.770 0.234
ENSG00000162585 E029 0.5180316 0.0223680354 7.136541e-01 8.100899e-01 1 2201050 2201225 176 - 0.000 0.164 11.098
ENSG00000162585 E030 0.0000000       1 2203436 2203563 128 -      
ENSG00000162585 E031 0.0000000       1 2203564 2203630 67 -      
ENSG00000162585 E032 0.0000000       1 2203631 2203882 252 -      
ENSG00000162585 E033 0.1451727 0.0426984750 8.978384e-02   1 2206305 2206424 120 - 0.229 0.000 -12.774
ENSG00000162585 E034 0.1451727 0.0426984750 8.978384e-02   1 2206515 2206667 153 - 0.229 0.000 -12.774
ENSG00000162585 E035 0.0000000       1 2207556 2207733 178 -      
ENSG00000162585 E036 1.7263370 0.0459717757 3.818879e-01 5.261499e-01 1 2212171 2212371 201 - 0.488 0.317 -0.954
ENSG00000162585 E037 1.3274538 0.0099065264 1.948576e-01 3.198225e-01 1 2212372 2212458 87 - 0.488 0.247 -1.444
ENSG00000162585 E038 0.7479104 0.6014557834 3.712921e-01 5.157245e-01 1 2212549 2212720 172 - 0.379 0.155 -1.701