ENSG00000162493

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000294489 ENSG00000162493 HEK293_OSMI2_2hA HEK293_TMG_2hB PDPN protein_coding protein_coding 18.1302 23.18015 18.53721 0.7150335 1.089977 -0.3223096 1.172398 1.714631 1.0374727 0.2758643 0.1608416 -0.7193754 0.06633333 0.07416667 0.05733333 -0.01683333 7.183835e-01 3.446374e-10 FALSE TRUE
ENST00000376057 ENSG00000162493 HEK293_OSMI2_2hA HEK293_TMG_2hB PDPN protein_coding protein_coding 18.1302 23.18015 18.53721 0.7150335 1.089977 -0.3223096 5.188168 6.978551 4.3920784 0.7785513 0.5497968 -0.6668086 0.28720833 0.30083333 0.24176667 -0.05906667 6.369616e-01 3.446374e-10 FALSE TRUE
ENST00000510906 ENSG00000162493 HEK293_OSMI2_2hA HEK293_TMG_2hB PDPN protein_coding protein_coding 18.1302 23.18015 18.53721 0.7150335 1.089977 -0.3223096 5.951973 4.633504 8.6766371 0.3926769 1.1924549 0.9035840 0.33605000 0.19923333 0.46390000 0.26466667 1.261068e-07 3.446374e-10 FALSE TRUE
ENST00000621990 ENSG00000162493 HEK293_OSMI2_2hA HEK293_TMG_2hB PDPN protein_coding protein_coding 18.1302 23.18015 18.53721 0.7150335 1.089977 -0.3223096 3.804554 5.075008 3.6973279 1.0852686 0.4635743 -0.4558703 0.20753750 0.21840000 0.19800000 -0.02040000 9.289388e-01 3.446374e-10 FALSE TRUE
MSTRG.338.3 ENSG00000162493 HEK293_OSMI2_2hA HEK293_TMG_2hB PDPN protein_coding   18.1302 23.18015 18.53721 0.7150335 1.089977 -0.3223096 1.862855 4.611469 0.6530208 0.3123212 0.1693603 -2.8012253 0.09440000 0.20016667 0.03443333 -0.16573333 3.446374e-10 3.446374e-10 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162493 E001 10.1819733 0.0018960167 8.756586e-01 9.241480e-01 1 13583465 13583761 297 + 1.015 1.038 0.085
ENSG00000162493 E002 19.2473511 0.0248688338 3.155596e-01 4.583231e-01 1 13583762 13583805 44 + 1.204 1.321 0.410
ENSG00000162493 E003 36.4659635 0.0206137015 2.407655e-01 3.750703e-01 1 13583806 13583831 26 + 1.474 1.585 0.380
ENSG00000162493 E004 30.9054588 0.0301739685 3.685404e-01 5.129510e-01 1 13583832 13583832 1 + 1.411 1.512 0.350
ENSG00000162493 E005 199.6204922 0.0019728253 1.651919e-01 2.819304e-01 1 13583833 13584092 260 + 2.248 2.297 0.163
ENSG00000162493 E006 87.6853407 0.0017238288 7.788788e-01 8.577505e-01 1 13584093 13584100 8 + 1.913 1.931 0.061
ENSG00000162493 E007 0.2965864 0.1338750638 3.943213e-01   1 13584101 13584188 88 + 0.000 0.180 9.850
ENSG00000162493 E008 0.0000000       1 13584267 13584269 3 +      
ENSG00000162493 E009 0.4751703 0.0219683994 8.606625e-01 9.141312e-01 1 13584270 13584341 72 + 0.148 0.182 0.359
ENSG00000162493 E010 0.3289534 0.0285979616 7.380793e-01   1 13585461 13585471 11 + 0.148 0.101 -0.639
ENSG00000162493 E011 0.1472490 0.0427514842 3.171486e-01   1 13585472 13585479 8 + 0.148 0.000 -10.759
ENSG00000162493 E012 1.4726265 0.0092738139 7.277279e-01 8.203342e-01 1 13585480 13585568 89 + 0.419 0.362 -0.318
ENSG00000162493 E013 0.5879639 0.0210188972 1.453839e-01 2.553829e-01 1 13585569 13585592 24 + 0.346 0.101 -2.226
ENSG00000162493 E014 12.0130785 0.0016796534 1.700713e-05 1.071876e-04 1 13585593 13585639 47 + 0.704 1.208 1.897
ENSG00000162493 E015 13.3864269 0.0014921948 3.140588e-06 2.339106e-05 1 13585640 13585714 75 + 0.738 1.260 1.945
ENSG00000162493 E016 30.2616146 0.0006824017 5.007467e-16 1.967745e-14 1 13590963 13591264 302 + 0.940 1.614 2.379
ENSG00000162493 E017 0.5901394 0.4073500619 9.080095e-01 9.456001e-01 1 13595827 13595984 158 + 0.148 0.190 0.431
ENSG00000162493 E018 188.2590949 0.0033226583 1.453358e-03 5.484722e-03 1 13607173 13607306 134 + 2.324 2.216 -0.360
ENSG00000162493 E019 209.0754296 0.0005362406 4.987712e-08 5.378876e-07 1 13610387 13610516 130 + 2.384 2.254 -0.431
ENSG00000162493 E020 131.8743636 0.0002664522 9.847260e-05 5.147578e-04 1 13613687 13613725 39 + 2.175 2.064 -0.371
ENSG00000162493 E021 181.7303192 0.0003010295 1.216551e-01 2.222959e-01 1 13614300 13614405 106 + 2.266 2.233 -0.110
ENSG00000162493 E022 53.3573118 0.0015947059 7.193811e-01 8.142379e-01 1 13614406 13614411 6 + 1.700 1.727 0.091
ENSG00000162493 E023 1.6250738 0.2217193613 3.025043e-01 4.443727e-01 1 13614412 13614514 103 + 0.536 0.351 -0.969
ENSG00000162493 E024 638.5779856 0.0012054546 1.706512e-03 6.302510e-03 1 13615905 13617957 2053 + 2.747 2.806 0.195