ENSG00000162441

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377213 ENSG00000162441 HEK293_OSMI2_2hA HEK293_TMG_2hB LZIC protein_coding protein_coding 22.85009 12.24993 38.29682 0.2450469 1.580236 1.643651 11.887709 6.815676 20.570602 0.3798505 1.2194115 1.592241 0.51965833 0.55713333 0.53636667 -0.02076667 8.800361e-01 1.059252e-09 FALSE TRUE
ENST00000377223 ENSG00000162441 HEK293_OSMI2_2hA HEK293_TMG_2hB LZIC protein_coding protein_coding 22.85009 12.24993 38.29682 0.2450469 1.580236 1.643651 7.641956 4.409701 12.750764 0.6531886 0.4540526 1.529694 0.34097917 0.35846667 0.33326667 -0.02520000 8.716716e-01 1.059252e-09 FALSE TRUE
ENST00000400903 ENSG00000162441 HEK293_OSMI2_2hA HEK293_TMG_2hB LZIC protein_coding protein_coding 22.85009 12.24993 38.29682 0.2450469 1.580236 1.643651 1.582654 0.000000 2.354130 0.0000000 0.4743564 7.885165 0.04805417 0.00000000 0.06106667 0.06106667 1.059252e-09 1.059252e-09 FALSE TRUE
MSTRG.268.1 ENSG00000162441 HEK293_OSMI2_2hA HEK293_TMG_2hB LZIC protein_coding   22.85009 12.24993 38.29682 0.2450469 1.580236 1.643651 1.616457 1.024548 2.521782 0.2286684 0.2927512 1.291152 0.08225000 0.08443333 0.06660000 -0.01783333 7.953728e-01 1.059252e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162441 E001 9.1894345 0.0046109597 1.632919e-01 2.794579e-01 1 9922113 9922358 246 - 0.911 1.087 0.653
ENSG00000162441 E002 719.8496858 0.0119554888 3.863990e-01 5.305803e-01 1 9926293 9929719 3427 - 2.806 2.864 0.194
ENSG00000162441 E003 161.5482298 0.0003875173 2.114469e-06 1.636088e-05 1 9929720 9930252 533 - 2.216 2.089 -0.427
ENSG00000162441 E004 42.5401096 0.0005051721 1.747668e-04 8.558847e-04 1 9930253 9930260 8 - 1.663 1.451 -0.725
ENSG00000162441 E005 147.0555942 0.0002341969 5.389374e-01 6.702685e-01 1 9930261 9930457 197 - 2.139 2.142 0.012
ENSG00000162441 E006 128.2601032 0.0002489941 4.209646e-02 9.490740e-02 1 9931891 9931972 82 - 2.050 2.139 0.298
ENSG00000162441 E007 0.8168978 0.0150210289 6.916082e-01 7.930472e-01 1 9931973 9932180 208 - 0.254 0.186 -0.569
ENSG00000162441 E008 161.2230693 0.0022296215 4.814140e-02 1.058807e-01 1 9932803 9932898 96 - 2.147 2.237 0.302
ENSG00000162441 E009 177.5194126 0.0014563102 1.249031e-01 2.269896e-01 1 9934762 9934860 99 - 2.195 2.265 0.233
ENSG00000162441 E010 208.1143121 0.0002543155 3.051448e-01 4.471871e-01 1 9935492 9935627 136 - 2.288 2.284 -0.016
ENSG00000162441 E011 199.1715118 0.0044532303 1.617362e-01 2.773821e-01 1 9936519 9936627 109 - 2.279 2.238 -0.137
ENSG00000162441 E012 199.4627782 0.0003903736 6.001905e-03 1.861533e-02 1 9942624 9942782 159 - 2.285 2.230 -0.184
ENSG00000162441 E013 51.5274564 0.0041278767 4.215605e-01 5.646928e-01 1 9943249 9943348 100 - 1.667 1.735 0.232
ENSG00000162441 E014 19.3195423 0.0127644605 4.212362e-01 5.643661e-01 1 9943349 9943407 59 - 1.297 1.231 -0.232