ENSG00000162437

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000294428 ENSG00000162437 HEK293_OSMI2_2hA HEK293_TMG_2hB RAVER2 protein_coding protein_coding 14.31072 8.040572 20.68616 0.3261697 0.5525122 1.3622 1.3676002 0.8783702 1.57242537 0.1140377 0.46837950 0.8329045 0.09949583 0.11060000 0.075566667 -0.03503333 5.446681e-01 2.034647e-05 FALSE TRUE
ENST00000371072 ENSG00000162437 HEK293_OSMI2_2hA HEK293_TMG_2hB RAVER2 protein_coding protein_coding 14.31072 8.040572 20.68616 0.3261697 0.5525122 1.3622 10.6421314 4.4929115 16.96269232 0.3099938 0.56310421 1.9142854 0.70212083 0.56326667 0.820933333 0.25766667 4.994984e-03 2.034647e-05 FALSE TRUE
MSTRG.1353.5 ENSG00000162437 HEK293_OSMI2_2hA HEK293_TMG_2hB RAVER2 protein_coding   14.31072 8.040572 20.68616 0.3261697 0.5525122 1.3622 0.9312905 0.2144016 1.65971056 0.1136286 0.33650241 2.8954434 0.05548333 0.02583333 0.079900000 0.05406667 2.192073e-01 2.034647e-05 TRUE TRUE
MSTRG.1353.7 ENSG00000162437 HEK293_OSMI2_2hA HEK293_TMG_2hB RAVER2 protein_coding   14.31072 8.040572 20.68616 0.3261697 0.5525122 1.3622 0.9409661 2.3104449 0.06017826 0.6267651 0.06017826 -5.0472334 0.11492917 0.28216667 0.002833333 -0.27933333 2.034647e-05 2.034647e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162437 E001 7.532826 0.0021630337 4.257932e-01 5.686868e-01 1 64745075 64745084 10 + 0.840 1.007 0.633
ENSG00000162437 E002 9.573939 0.0018901317 5.942986e-01 7.165556e-01 1 64745085 64745094 10 + 0.942 1.075 0.489
ENSG00000162437 E003 12.720772 0.0014243334 6.314033e-01 7.464055e-01 1 64745095 64745134 40 + 1.089 1.115 0.095
ENSG00000162437 E004 12.114710 0.0021851509 8.361499e-01 8.975510e-01 1 64745135 64745185 51 + 1.062 1.115 0.193
ENSG00000162437 E005 39.756628 0.0182399211 8.002699e-04 3.260613e-03 1 64745186 64745421 236 + 1.619 1.380 -0.821
ENSG00000162437 E006 40.834264 0.0010812526 1.810847e-07 1.749947e-06 1 64768656 64768722 67 + 1.637 1.358 -0.957
ENSG00000162437 E007 195.658746 0.0051928465 8.506446e-08 8.753983e-07 1 64777623 64778065 443 + 2.286 2.127 -0.533
ENSG00000162437 E008 54.419733 0.0043025860 7.663082e-02 1.541036e-01 1 64778066 64778092 27 + 1.706 1.676 -0.102
ENSG00000162437 E009 0.294498 0.4202930729 7.451313e-01   1 64780709 64780755 47 + 0.136 0.000 -8.403
ENSG00000162437 E010 124.500585 0.0006988963 3.200063e-07 2.943352e-06 1 64781380 64781571 192 + 2.082 1.970 -0.375
ENSG00000162437 E011 98.823940 0.0003325289 2.084110e-07 1.990966e-06 1 64789388 64789514 127 + 1.987 1.854 -0.446
ENSG00000162437 E012 75.941881 0.0003666185 1.661147e-02 4.408295e-02 1 64802976 64803061 86 + 1.849 1.822 -0.092
ENSG00000162437 E013 2.584149 0.0273296500 4.300332e-01 5.726692e-01 1 64804734 64804772 39 + 0.455 0.648 0.899
ENSG00000162437 E014 71.259451 0.0003380070 1.654995e-01 2.823510e-01 1 64804773 64804838 66 + 1.809 1.826 0.057
ENSG00000162437 E015 83.703119 0.0004086503 2.225420e-03 7.922412e-03 1 64804991 64805049 59 + 1.896 1.844 -0.177
ENSG00000162437 E016 81.639865 0.0004431296 2.306728e-02 5.789034e-02 1 64805050 64805105 56 + 1.877 1.858 -0.063
ENSG00000162437 E017 8.868041 0.0018266141 2.950512e-03 1.011824e-02 1 64805106 64805146 41 + 1.026 0.700 -1.260
ENSG00000162437 E018 165.016487 0.0002898645 3.821508e-03 1.263986e-02 1 64807206 64807474 269 + 2.175 2.168 -0.024
ENSG00000162437 E019 87.441424 0.0023063782 4.255739e-02 9.574010e-02 1 64812738 64812849 112 + 1.906 1.891 -0.052
ENSG00000162437 E020 103.634397 0.0002901317 5.074920e-01 6.429928e-01 1 64814704 64814840 137 + 1.957 2.013 0.188
ENSG00000162437 E021 7.989156 0.0259366976 2.000356e-02 5.149601e-02 1 64814841 64816509 1669 + 0.778 1.164 1.444
ENSG00000162437 E022 7.659741 0.0054811516 4.452281e-01 5.867953e-01 1 64825254 64825408 155 + 0.894 0.864 -0.114
ENSG00000162437 E023 944.679316 0.0040044666 5.683616e-17 2.518699e-15 1 64830839 64833232 2394 + 2.846 3.091 0.817