ENSG00000162390

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371316 ENSG00000162390 HEK293_OSMI2_2hA HEK293_TMG_2hB ACOT11 protein_coding protein_coding 1.076886 2.223153 0.8030778 0.03688747 0.02158594 -1.457617 0.04389015 0.02523382 0.02095172 0.002933349 0.011703378 -0.1869412 0.06862500 0.01136667 0.02563333 0.01426667 0.66832000 0.02354334 FALSE TRUE
ENST00000479837 ENSG00000162390 HEK293_OSMI2_2hA HEK293_TMG_2hB ACOT11 protein_coding processed_transcript 1.076886 2.223153 0.8030778 0.03688747 0.02158594 -1.457617 0.07477084 0.08138358 0.12742737 0.044212364 0.076925146 0.5886625 0.07132917 0.03613333 0.15393333 0.11780000 0.52180952 0.02354334   FALSE
ENST00000481208 ENSG00000162390 HEK293_OSMI2_2hA HEK293_TMG_2hB ACOT11 protein_coding processed_transcript 1.076886 2.223153 0.8030778 0.03688747 0.02158594 -1.457617 0.52305346 1.27596115 0.28022992 0.190482479 0.111962950 -2.1475789 0.47257917 0.57190000 0.34273333 -0.22916667 0.37076839 0.02354334 FALSE TRUE
ENST00000498228 ENSG00000162390 HEK293_OSMI2_2hA HEK293_TMG_2hB ACOT11 protein_coding processed_transcript 1.076886 2.223153 0.8030778 0.03688747 0.02158594 -1.457617 0.02125815 0.00000000 0.04839578 0.000000000 0.006944946 2.5458641 0.04049167 0.00000000 0.06076667 0.06076667 0.02354334 0.02354334 FALSE TRUE
MSTRG.1240.2 ENSG00000162390 HEK293_OSMI2_2hA HEK293_TMG_2hB ACOT11 protein_coding   1.076886 2.223153 0.8030778 0.03688747 0.02158594 -1.457617 0.41391307 0.84057462 0.32607298 0.205828595 0.163038505 -1.3396633 0.34697917 0.38060000 0.41693333 0.03633333 1.00000000 0.02354334 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162390 E001 5.4644620 0.0060680339 0.718284916 0.81343393 1 54542257 54542365 109 + 0.777 0.720 -0.231
ENSG00000162390 E002 7.0728982 0.0024434147 0.080737977 0.16070149 1 54542366 54542437 72 + 0.987 0.761 -0.871
ENSG00000162390 E003 0.0000000       1 54548220 54548227 8 +      
ENSG00000162390 E004 0.0000000       1 54548228 54548342 115 +      
ENSG00000162390 E005 0.1472490 0.0429001669 0.123559495   1 54548467 54548619 153 + 0.210 0.000 -12.996
ENSG00000162390 E006 11.9250838 0.0020024287 0.192890887 0.31740044 1 54584655 54584862 208 + 1.129 0.986 -0.522
ENSG00000162390 E007 5.2363095 0.1821848621 0.440240054 0.58191788 1 54585835 54585904 70 + 0.857 0.669 -0.758
ENSG00000162390 E008 7.0922866 0.0033254300 0.417591932 0.56092755 1 54592546 54592606 61 + 0.729 0.842 0.449
ENSG00000162390 E009 10.3321488 0.0019189741 0.944743093 0.96930400 1 54593941 54594039 99 + 0.959 0.962 0.012
ENSG00000162390 E010 10.9288068 0.0019121334 0.480064079 0.61836954 1 54594556 54594691 136 + 1.040 0.954 -0.316
ENSG00000162390 E011 5.3399754 0.0986566924 0.989166704 0.99727877 1 54597259 54597263 5 + 0.729 0.706 -0.091
ENSG00000162390 E012 12.0788081 0.0018112571 0.556146925 0.68486978 1 54597264 54597415 152 + 1.064 0.994 -0.257
ENSG00000162390 E013 0.1515154 0.0432666684 0.123301049   1 54597416 54598858 1443 + 0.210 0.000 -12.995
ENSG00000162390 E014 9.0615620 0.0021598870 0.709903126 0.80716011 1 54599296 54599415 120 + 0.859 0.902 0.166
ENSG00000162390 E015 0.8179419 0.0163891739 0.066809802 0.13807947 1 54599416 54599658 243 + 0.458 0.127 -2.456
ENSG00000162390 E016 9.2182783 0.0019324716 0.168365266 0.28606029 1 54601269 54601413 145 + 1.040 0.873 -0.623
ENSG00000162390 E017 7.3971317 0.1024846499 0.593944501 0.71624358 1 54602669 54602724 56 + 0.929 0.799 -0.503
ENSG00000162390 E018 8.0433841 0.0024200403 0.330999301 0.47457712 1 54603871 54603937 67 + 0.959 0.832 -0.484
ENSG00000162390 E019 10.1520577 0.0020056577 0.354008779 0.49829410 1 54604346 54604429 84 + 1.040 0.929 -0.413
ENSG00000162390 E020 11.9721918 0.0016125801 0.069455986 0.14245903 1 54605076 54605209 134 + 0.820 1.043 0.842
ENSG00000162390 E021 11.1722379 0.0017829061 0.736155184 0.82671914 1 54607134 54607265 132 + 0.959 0.993 0.128
ENSG00000162390 E022 13.5190039 0.0013415823 0.795281075 0.86925604 1 54607942 54608068 127 + 1.040 1.063 0.083
ENSG00000162390 E023 68.3132660 0.0005667172 0.001318583 0.00503927 1 54608957 54610329 1373 + 1.604 1.754 0.509
ENSG00000162390 E024 0.3299976 0.0274424043 0.966401003   1 54630734 54630886 153 + 0.000 0.127 10.652
ENSG00000162390 E025 0.7331471 0.0158255519 0.356304854 0.50068791 1 54634688 54639192 4505 + 0.000 0.226 11.580