ENSG00000162384

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000294360 ENSG00000162384 HEK293_OSMI2_2hA HEK293_TMG_2hB CZIB protein_coding protein_coding 54.96287 68.10169 57.87379 6.83475 1.111077 -0.2347431 33.892701 45.414020 37.158821 6.9460505 0.8050095 -0.2893625 0.61028333 0.66030000 0.64210000 -0.01820000 8.686747e-01 5.389432e-10 FALSE  
ENST00000474227 ENSG00000162384 HEK293_OSMI2_2hA HEK293_TMG_2hB CZIB protein_coding retained_intron 54.96287 68.10169 57.87379 6.83475 1.111077 -0.2347431 4.018104 3.739618 4.866808 0.4171015 0.3250963 0.3791936 0.07590417 0.05596667 0.08413333 0.02816667 1.622359e-01 5.389432e-10    
ENST00000489755 ENSG00000162384 HEK293_OSMI2_2hA HEK293_TMG_2hB CZIB protein_coding retained_intron 54.96287 68.10169 57.87379 6.83475 1.111077 -0.2347431 3.365504 1.805004 4.253245 0.2310557 0.0921918 1.2319794 0.06460000 0.02656667 0.07356667 0.04700000 5.389432e-10 5.389432e-10    
MSTRG.1219.5 ENSG00000162384 HEK293_OSMI2_2hA HEK293_TMG_2hB CZIB protein_coding   54.96287 68.10169 57.87379 6.83475 1.111077 -0.2347431 6.088049 10.751754 4.042916 0.7669018 0.6868531 -1.4088810 0.10633333 0.16296667 0.06986667 -0.09310000 2.703042e-02 5.389432e-10 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162384 E001 20.446002 0.0024639690 4.943398e-01 6.312934e-01 1 53214099 53214136 38 - 1.288 1.352 0.221
ENSG00000162384 E002 213.085201 0.0029921677 5.997163e-01 7.210695e-01 1 53214137 53214374 238 - 2.327 2.318 -0.030
ENSG00000162384 E003 209.078571 0.0029079640 9.303081e-01 9.601599e-01 1 53214375 53214472 98 - 2.310 2.316 0.018
ENSG00000162384 E004 112.820533 0.0016998776 9.299509e-01 9.599064e-01 1 53214473 53214473 1 - 2.043 2.055 0.043
ENSG00000162384 E005 122.247655 0.0006287056 6.800411e-01 7.840477e-01 1 53214474 53214476 3 - 2.089 2.084 -0.016
ENSG00000162384 E006 613.664503 0.0026507090 5.575258e-02 1.192669e-01 1 53214477 53214736 260 - 2.742 2.797 0.183
ENSG00000162384 E007 371.630641 0.0001473374 7.582320e-04 3.108858e-03 1 53215991 53216056 66 - 2.518 2.590 0.239
ENSG00000162384 E008 240.573292 0.0001920056 1.476939e-01 2.585584e-01 1 53216782 53216785 4 - 2.350 2.393 0.142
ENSG00000162384 E009 418.689917 0.0001697559 1.777008e-01 2.982335e-01 1 53216786 53216859 74 - 2.595 2.627 0.107
ENSG00000162384 E010 21.224048 0.0042048655 4.837740e-03 1.548003e-02 1 53216860 53218171 1312 - 1.457 1.244 -0.741
ENSG00000162384 E011 294.848659 0.0017501133 3.900896e-02 8.921399e-02 1 53218172 53218203 32 - 2.422 2.481 0.198
ENSG00000162384 E012 9.224514 0.0018897752 5.182692e-01 6.525364e-01 1 53218204 53218360 157 - 1.040 0.980 -0.222
ENSG00000162384 E013 381.407747 0.0007766232 4.541788e-01 5.948409e-01 1 53218414 53218495 82 - 2.560 2.580 0.068
ENSG00000162384 E014 51.634126 0.0004683628 2.930734e-16 1.190690e-14 1 53218496 53218866 371 - 1.914 1.526 -1.315
ENSG00000162384 E015 338.822350 0.0001993636 8.914799e-02 1.738266e-01 1 53218867 53218923 57 - 2.538 2.513 -0.084
ENSG00000162384 E016 69.432434 0.0005741083 3.767268e-24 3.788204e-22 1 53218924 53219534 611 - 2.052 1.624 -1.441
ENSG00000162384 E017 57.931870 0.0004943165 8.085666e-23 7.036312e-21 1 53219535 53219969 435 - 1.985 1.536 -1.517
ENSG00000162384 E018 28.286723 0.0053695015 5.951996e-10 9.206300e-09 1 53219970 53220086 117 - 1.680 1.230 -1.550
ENSG00000162384 E019 60.542554 0.0135080861 6.419065e-01 7.548510e-01 1 53220087 53220260 174 - 1.756 1.784 0.094
ENSG00000162384 E020 375.804180 0.0009352724 9.558946e-02 1.837754e-01 1 53220261 53220344 84 - 2.539 2.580 0.136
ENSG00000162384 E021 37.435415 0.0005742839 5.747146e-03 1.794711e-02 1 53220345 53220476 132 - 1.665 1.518 -0.501
ENSG00000162384 E022 19.871460 0.0010456868 1.370402e-01 2.439703e-01 1 53220477 53220569 93 - 1.381 1.277 -0.361
ENSG00000162384 E023 217.261395 0.0002466095 4.532815e-03 1.463508e-02 1 53220570 53220634 65 - 2.278 2.357 0.264