ENSG00000162302

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334205 ENSG00000162302 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KA4 protein_coding protein_coding 25.95734 42.32589 16.86031 3.682711 2.037888 -1.327395 16.868520 27.531728 9.540538 2.11681519 0.2023795 -1.5279652 0.64044167 0.65170000 0.58493333 -0.06676667 7.760741e-01 8.468651e-05 FALSE  
ENST00000528057 ENSG00000162302 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KA4 protein_coding protein_coding 25.95734 42.32589 16.86031 3.682711 2.037888 -1.327395 2.825881 6.946223 1.532200 1.36058929 0.8091021 -2.1733147 0.09605417 0.16076667 0.09266667 -0.06810000 7.108404e-01 8.468651e-05 FALSE  
ENST00000532496 ENSG00000162302 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KA4 protein_coding retained_intron 25.95734 42.32589 16.86031 3.682711 2.037888 -1.327395 1.480235 1.334775 1.868837 0.50582536 0.9474329 0.4824754 0.06838750 0.03086667 0.09953333 0.06866667 8.461305e-01 8.468651e-05 FALSE  
ENST00000532885 ENSG00000162302 HEK293_OSMI2_2hA HEK293_TMG_2hB RPS6KA4 protein_coding retained_intron 25.95734 42.32589 16.86031 3.682711 2.037888 -1.327395 1.513263 1.015982 1.468031 0.06069044 0.3358594 0.5266701 0.07167083 0.02466667 0.08466667 0.06000000 8.468651e-05 8.468651e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162302 E001 0.0000000       11 64359120 64359124 5 +      
ENSG00000162302 E002 0.7406253 0.0153787590 3.042514e-04 1.396610e-03 11 64359125 64359147 23 + 0.591 0.000 -12.529
ENSG00000162302 E003 5.7347387 0.0244593479 5.821108e-03 1.814000e-02 11 64359148 64359161 14 + 1.036 0.648 -1.518
ENSG00000162302 E004 32.2062349 0.0006422288 1.977482e-03 7.157038e-03 11 64359162 64359180 19 + 1.582 1.380 -0.693
ENSG00000162302 E005 32.5696437 0.0006551429 2.667137e-03 9.273764e-03 11 64359181 64359181 1 + 1.582 1.387 -0.670
ENSG00000162302 E006 130.6880587 0.0021501414 2.901197e-06 2.178019e-05 11 64359182 64359283 102 + 2.160 1.980 -0.601
ENSG00000162302 E007 95.6336164 0.0035497561 1.337769e-05 8.629635e-05 11 64359284 64359290 7 + 2.042 1.841 -0.676
ENSG00000162302 E008 117.0741214 0.0012689662 1.972575e-05 1.225176e-04 11 64359378 64359403 26 + 2.098 1.936 -0.541
ENSG00000162302 E009 134.5881987 0.0004492364 8.847225e-07 7.433058e-06 11 64359404 64359449 46 + 2.160 1.995 -0.553
ENSG00000162302 E010 1.2565659 0.0123625139 2.688755e-01 4.073448e-01 11 64359450 64359788 339 + 0.438 0.238 -1.252
ENSG00000162302 E011 236.0587546 0.0013661108 2.070914e-02 5.297440e-02 11 64360163 64360381 219 + 2.326 2.263 -0.211
ENSG00000162302 E012 124.5764014 0.0002888535 2.116366e-01 3.404235e-01 11 64360477 64360516 40 + 2.030 1.990 -0.134
ENSG00000162302 E013 188.7533859 0.0002853053 2.262279e-01 3.578703e-01 11 64360517 64360592 76 + 2.203 2.173 -0.101
ENSG00000162302 E014 4.9075199 0.1139542684 9.813376e-02 1.876813e-01 11 64360593 64360631 39 + 0.930 0.600 -1.337
ENSG00000162302 E015 7.7172146 0.1317170820 3.633592e-02 8.421909e-02 11 64360990 64361133 144 + 1.155 0.725 -1.625
ENSG00000162302 E016 253.0682695 0.0004387620 1.856396e-01 3.082906e-01 11 64361134 64361241 108 + 2.329 2.301 -0.095
ENSG00000162302 E017 245.6535991 0.0005565624 6.571963e-02 1.362378e-01 11 64361469 64361549 81 + 2.329 2.285 -0.147
ENSG00000162302 E018 249.8190277 0.0011641958 1.836981e-01 3.058384e-01 11 64361642 64361745 104 + 2.328 2.296 -0.107
ENSG00000162302 E019 163.4480302 0.0019966939 4.239688e-01 5.669829e-01 11 64361852 64361906 55 + 2.085 2.126 0.136
ENSG00000162302 E020 204.3979122 0.0002738845 9.146727e-01 9.499827e-01 11 64361907 64362002 96 + 2.206 2.216 0.035
ENSG00000162302 E021 287.2191820 0.0001838379 4.365896e-01 5.786484e-01 11 64365301 64365465 165 + 2.341 2.368 0.090
ENSG00000162302 E022 316.0322081 0.0001661709 2.658872e-01 4.039904e-01 11 64368132 64368260 129 + 2.374 2.409 0.115
ENSG00000162302 E023 3.3537000 0.0046058045 2.576761e-01 3.948362e-01 11 64368261 64368403 143 + 0.704 0.528 -0.777
ENSG00000162302 E024 117.5001108 0.0002762988 2.558156e-01 3.927477e-01 11 64368468 64368485 18 + 1.933 1.986 0.177
ENSG00000162302 E025 94.7945010 0.0003297782 7.839407e-01 8.614022e-01 11 64368486 64368488 3 + 1.870 1.889 0.064
ENSG00000162302 E026 244.6088985 0.0002061941 1.519514e-02 4.093036e-02 11 64368489 64368601 113 + 2.229 2.305 0.254
ENSG00000162302 E027 202.9682559 0.0001989403 4.560615e-05 2.595280e-04 11 64368704 64368797 94 + 2.098 2.235 0.459
ENSG00000162302 E028 255.8431514 0.0006963622 4.581401e-02 1.016898e-01 11 64369446 64369619 174 + 2.259 2.327 0.226
ENSG00000162302 E029 283.6217222 0.0002970886 7.808673e-02 1.563968e-01 11 64369699 64369893 195 + 2.313 2.367 0.182
ENSG00000162302 E030 121.2075134 0.0060268720 7.700307e-01 8.515159e-01 11 64370225 64370245 21 + 1.970 1.998 0.094
ENSG00000162302 E031 211.8061392 0.0004392670 3.213208e-01 4.645431e-01 11 64370246 64370384 139 + 2.198 2.237 0.129
ENSG00000162302 E032 201.0736742 0.0025466037 4.686089e-02 1.035839e-01 11 64370563 64370726 164 + 2.134 2.225 0.301
ENSG00000162302 E033 755.7818959 0.0042822462 8.765926e-04 3.532524e-03 11 64371283 64372252 970 + 2.688 2.809 0.402