ENSG00000162191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301935 ENSG00000162191 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN1 protein_coding protein_coding 156.1706 282.8339 90.18255 6.015856 3.249664 -1.648926 132.03051 250.75341 67.916107 3.741624 3.311869 -1.8842888 0.8200583 0.88696667 0.75396667 -0.1330 0.00419305 4.785498e-20 FALSE TRUE
ENST00000534176 ENSG00000162191 HEK293_OSMI2_2hA HEK293_TMG_2hB UBXN1 protein_coding protein_coding 156.1706 282.8339 90.18255 6.015856 3.249664 -1.648926 7.83592 11.22151 7.094033 1.396792 1.396330 -0.6608411 0.0556750 0.03956667 0.07796667 0.0384 0.04328069 4.785498e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162191 E001 1.728618 8.133366e-03 2.128068e-05 1.311120e-04 11 62676498 62676498 1 - 0.827 0.125 -4.096
ENSG00000162191 E002 1.728618 8.133366e-03 2.128068e-05 1.311120e-04 11 62676499 62676499 1 - 0.827 0.125 -4.099
ENSG00000162191 E003 10.156774 1.951875e-03 9.019736e-01 9.415455e-01 11 62676500 62676500 1 - 0.967 0.946 -0.077
ENSG00000162191 E004 16.421191 1.121111e-03 7.694695e-01 8.511139e-01 11 62676501 62676503 3 - 1.116 1.141 0.088
ENSG00000162191 E005 62.719758 1.033430e-02 9.907304e-08 1.006601e-06 11 62676504 62676516 13 - 1.966 1.594 -1.258
ENSG00000162191 E006 543.243780 2.197847e-04 4.487523e-06 3.229186e-05 11 62676517 62676612 96 - 2.545 2.636 0.300
ENSG00000162191 E007 553.672340 3.684847e-04 2.793459e-10 4.569266e-09 11 62676613 62676639 27 - 2.517 2.650 0.445
ENSG00000162191 E008 38.138112 4.186139e-03 1.647217e-06 1.304764e-05 11 62676640 62676812 173 - 1.735 1.407 -1.121
ENSG00000162191 E009 934.081295 3.335565e-04 1.660954e-10 2.823861e-09 11 62676813 62676896 84 - 2.768 2.873 0.351
ENSG00000162191 E010 1198.303327 1.909465e-04 2.424204e-10 4.001901e-09 11 62676897 62676979 83 - 2.891 2.977 0.286
ENSG00000162191 E011 719.299578 6.209738e-04 3.775385e-04 1.687672e-03 11 62676980 62676980 1 - 2.686 2.754 0.225
ENSG00000162191 E012 852.042687 3.615271e-04 1.794918e-05 1.125259e-04 11 62676981 62677005 25 - 2.757 2.828 0.236
ENSG00000162191 E013 56.601787 1.000996e-03 2.078455e-33 4.525944e-31 11 62677006 62677517 512 - 2.062 1.462 -2.031
ENSG00000162191 E014 802.389379 4.124923e-04 8.163124e-03 2.419663e-02 11 62677518 62677537 20 - 2.754 2.797 0.141
ENSG00000162191 E015 932.070592 9.361494e-05 5.068099e-03 1.611589e-02 11 62677538 62677563 26 - 2.824 2.861 0.121
ENSG00000162191 E016 906.162094 1.137121e-03 4.258759e-04 1.873599e-03 11 62677564 62677585 22 - 2.782 2.855 0.242
ENSG00000162191 E017 1146.232597 1.178616e-03 7.512512e-04 3.083639e-03 11 62677586 62677634 49 - 2.888 2.955 0.221
ENSG00000162191 E018 34.907635 8.192930e-03 7.725730e-12 1.638988e-10 11 62677635 62677739 105 - 1.806 1.297 -1.742
ENSG00000162191 E019 31.160262 1.484721e-02 9.661579e-10 1.436588e-08 11 62677740 62677780 41 - 1.770 1.242 -1.814
ENSG00000162191 E020 1068.263010 9.332175e-04 8.372070e-03 2.471813e-02 11 62677781 62677804 24 - 2.874 2.921 0.158
ENSG00000162191 E021 1143.969069 7.664137e-04 3.365214e-04 1.526470e-03 11 62677805 62677832 28 - 2.891 2.953 0.206
ENSG00000162191 E022 8.752780 2.094355e-03 8.697515e-06 5.860012e-05 11 62677833 62677917 85 - 1.244 0.740 -1.876
ENSG00000162191 E023 2.413974 1.732400e-02 7.183186e-07 6.154274e-06 11 62677918 62677926 9 - 0.967 0.176 -4.049
ENSG00000162191 E024 1078.567300 5.434991e-04 7.756780e-03 2.316638e-02 11 62677927 62677938 12 - 2.883 2.924 0.136
ENSG00000162191 E025 2252.564264 3.168489e-04 1.962866e-01 3.215800e-01 11 62677939 62678088 150 - 3.254 3.233 -0.070
ENSG00000162191 E026 1219.486200 8.330160e-05 1.274206e-08 1.540292e-07 11 62678089 62678118 30 - 3.034 2.956 -0.260
ENSG00000162191 E027 6.751433 2.566616e-03 4.449635e-02 9.927923e-02 11 62678119 62678208 90 - 0.995 0.727 -1.037
ENSG00000162191 E028 3.186775 5.005100e-02 3.258397e-04 1.484282e-03 11 62678209 62678338 130 - 0.967 0.364 -2.653
ENSG00000162191 E029 1394.610785 6.968895e-05 6.050281e-13 1.538327e-11 11 62678339 62678408 70 - 3.102 3.011 -0.301
ENSG00000162191 E030 5.278888 3.150366e-03 1.205564e-06 9.841449e-06 11 62678409 62678443 35 - 1.137 0.501 -2.552
ENSG00000162191 E031 4.581124 3.530789e-03 8.328720e-04 3.376310e-03 11 62678444 62678494 51 - 0.995 0.523 -1.931
ENSG00000162191 E032 1637.309729 8.603212e-04 2.087214e-09 2.911541e-08 11 62678495 62678601 107 - 3.184 3.076 -0.357
ENSG00000162191 E033 1055.933804 1.351215e-03 1.352406e-04 6.822970e-04 11 62678690 62678743 54 - 2.980 2.890 -0.298
ENSG00000162191 E034 39.437243 7.019862e-04 4.317800e-07 3.868278e-06 11 62678744 62678864 121 - 1.730 1.412 -1.086
ENSG00000162191 E035 956.147930 2.995758e-03 2.789566e-02 6.780472e-02 11 62678865 62678952 88 - 2.922 2.851 -0.238
ENSG00000162191 E036 724.216522 5.042690e-03 3.836701e-01 5.278668e-01 11 62678953 62679038 86 - 2.776 2.737 -0.132
ENSG00000162191 E037 387.866175 1.215532e-02 2.434196e-01 3.781942e-01 11 62679039 62679117 79 - 2.530 2.459 -0.235