ENSG00000162144

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000294072 ENSG00000162144 HEK293_OSMI2_2hA HEK293_TMG_2hB CYB561A3 protein_coding protein_coding 49.33687 86.02563 27.09545 6.619666 0.3062512 -1.666351 14.187342 21.463646 11.534865 4.1816117 1.1077570 -0.8953159 0.31434583 0.2445667 0.42500000 0.18043333 2.521755e-02 1.833125e-06 FALSE TRUE
ENST00000447532 ENSG00000162144 HEK293_OSMI2_2hA HEK293_TMG_2hB CYB561A3 protein_coding protein_coding 49.33687 86.02563 27.09545 6.619666 0.3062512 -1.666351 11.104115 25.956040 3.531960 0.5647773 0.3126961 -2.8740061 0.19646667 0.3050000 0.13066667 -0.17433333 1.833125e-06 1.833125e-06 FALSE TRUE
ENST00000535152 ENSG00000162144 HEK293_OSMI2_2hA HEK293_TMG_2hB CYB561A3 protein_coding processed_transcript 49.33687 86.02563 27.09545 6.619666 0.3062512 -1.666351 8.415092 14.173998 5.006157 3.5446255 1.7149041 -1.4996098 0.16432500 0.1599667 0.18466667 0.02470000 9.677137e-01 1.833125e-06   FALSE
ENST00000536687 ENSG00000162144 HEK293_OSMI2_2hA HEK293_TMG_2hB CYB561A3 protein_coding processed_transcript 49.33687 86.02563 27.09545 6.619666 0.3062512 -1.666351 2.814436 3.474107 2.045109 0.8963057 1.4190881 -0.7615743 0.06749167 0.0418000 0.07526667 0.03346667 9.948630e-01 1.833125e-06   FALSE
MSTRG.5564.2 ENSG00000162144 HEK293_OSMI2_2hA HEK293_TMG_2hB CYB561A3 protein_coding   49.33687 86.02563 27.09545 6.619666 0.3062512 -1.666351 8.844293 15.020948 2.940965 1.3728967 0.9999257 -2.3486771 0.17329583 0.1795000 0.10940000 -0.07010000 4.124144e-01 1.833125e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162144 E001 5.3434106 0.0044448459 7.622099e-01 8.458547e-01 11 61348754 61348804 51 - 0.662 0.721 0.246
ENSG00000162144 E002 20.4285368 0.0010274465 1.921448e-02 4.980266e-02 11 61348805 61348817 13 - 1.024 1.276 0.902
ENSG00000162144 E003 47.5140769 0.0028982950 3.941927e-02 8.995630e-02 11 61348818 61348837 20 - 1.455 1.615 0.548
ENSG00000162144 E004 163.7183201 0.0011563909 7.470810e-08 7.776498e-07 11 61348838 61348889 52 - 1.919 2.154 0.789
ENSG00000162144 E005 1358.8250614 0.0025027891 2.009839e-07 1.924712e-06 11 61348890 61349643 754 - 2.916 3.058 0.472
ENSG00000162144 E006 139.6994513 0.0002435256 7.744362e-01 8.546117e-01 11 61349644 61349646 3 - 2.024 2.048 0.082
ENSG00000162144 E007 143.0007225 0.0002401959 6.993630e-01 7.991437e-01 11 61349647 61349656 10 - 2.031 2.059 0.094
ENSG00000162144 E008 302.0267857 0.0002192119 7.303062e-02 1.483772e-01 11 61349657 61349840 184 - 2.403 2.372 -0.102
ENSG00000162144 E009 362.5233780 0.0004420453 9.371343e-05 4.924341e-04 11 61349841 61350125 285 - 2.519 2.442 -0.257
ENSG00000162144 E010 216.7962112 0.0001767115 5.692939e-05 3.162045e-04 11 61350126 61350279 154 - 2.313 2.213 -0.334
ENSG00000162144 E011 250.2212293 0.0010626356 6.239058e-03 1.924031e-02 11 61350280 61350422 143 - 2.348 2.281 -0.225
ENSG00000162144 E012 14.9242625 0.0013148488 5.249172e-02 1.135984e-01 11 61350423 61350990 568 - 0.913 1.149 0.868
ENSG00000162144 E013 303.8892568 0.0002637036 3.177035e-02 7.540746e-02 11 61350991 61351058 68 - 2.322 2.392 0.235
ENSG00000162144 E014 231.3717653 0.0001773937 6.360311e-02 1.326970e-01 11 61351059 61351096 38 - 2.206 2.275 0.229
ENSG00000162144 E015 217.8791389 0.0001840163 2.249351e-01 3.563430e-01 11 61351097 61351132 36 - 2.195 2.245 0.168
ENSG00000162144 E016 194.1344776 0.0012216162 2.152170e-01 3.446802e-01 11 61351133 61351147 15 - 2.136 2.196 0.200
ENSG00000162144 E017 24.9146477 0.0007951878 8.929775e-01 9.356078e-01 11 61351148 61352955 1808 - 1.291 1.315 0.085
ENSG00000162144 E018 4.1170241 0.0042005612 2.223232e-01 3.531749e-01 11 61352956 61352984 29 - 0.762 0.584 -0.755
ENSG00000162144 E019 167.9383104 0.0017470596 3.473877e-01 4.915969e-01 11 61352985 61352985 1 - 2.079 2.132 0.177
ENSG00000162144 E020 393.7693728 0.0012161795 8.688179e-01 9.196892e-01 11 61352986 61353105 120 - 2.482 2.494 0.041
ENSG00000162144 E021 239.8182613 0.0002001950 8.091754e-02 1.609659e-01 11 61353106 61353139 34 - 2.304 2.269 -0.116
ENSG00000162144 E022 5.0104074 0.0241159618 2.715698e-01 4.103405e-01 11 61353140 61353562 423 - 0.805 0.643 -0.663
ENSG00000162144 E023 250.7488610 0.0004876860 2.685011e-02 6.568110e-02 11 61353784 61353823 40 - 2.334 2.286 -0.160
ENSG00000162144 E024 184.2419253 0.0002123882 7.015804e-02 1.436318e-01 11 61353824 61353830 7 - 2.198 2.155 -0.144
ENSG00000162144 E025 205.5191360 0.0001836692 1.162207e-01 2.145797e-01 11 61353831 61353854 24 - 2.237 2.204 -0.111
ENSG00000162144 E026 312.3900581 0.0010753088 1.134327e-01 2.105306e-01 11 61353855 61353992 138 - 2.418 2.389 -0.097
ENSG00000162144 E027 7.9272294 0.0044983915 5.535012e-01 6.826192e-01 11 61353993 61354741 749 - 0.913 0.846 -0.253
ENSG00000162144 E028 1.6908495 0.0080128816 5.762733e-01 7.017539e-01 11 61356015 61356088 74 - 0.446 0.350 -0.534
ENSG00000162144 E029 0.8178402 0.0816870004 9.382633e-01 9.652167e-01 11 61356411 61356521 111 - 0.204 0.231 0.232
ENSG00000162144 E030 0.6663248 0.0969906747 3.727109e-01 5.171313e-01 11 61356522 61356529 8 - 0.000 0.231 14.304
ENSG00000162144 E031 146.9162265 0.0007532313 1.772420e-02 4.654040e-02 11 61356530 61356547 18 - 2.126 2.054 -0.241
ENSG00000162144 E032 255.6310396 0.0009840188 2.311229e-02 5.798182e-02 11 61356548 61356627 80 - 2.350 2.298 -0.176
ENSG00000162144 E033 285.5401042 0.0010580306 8.837078e-02 1.726327e-01 11 61356628 61356728 101 - 2.382 2.348 -0.114
ENSG00000162144 E034 1.3190347 0.0098851489 3.367383e-01 4.806085e-01 11 61356729 61356732 4 - 0.446 0.275 -1.019
ENSG00000162144 E035 0.9170165 0.0151627223 3.809826e-01 5.252603e-01 11 61356733 61356784 52 - 0.342 0.185 -1.167
ENSG00000162144 E036 1.5102764 0.0127391996 8.604539e-01 9.139916e-01 11 61356785 61356889 105 - 0.342 0.315 -0.167
ENSG00000162144 E037 5.3034819 0.0030549579 6.927163e-01 7.938794e-01 11 61357203 61357311 109 - 0.662 0.734 0.302
ENSG00000162144 E038 3.7931935 0.0616211981 7.011167e-01 8.004029e-01 11 61357312 61357371 60 - 0.662 0.600 -0.270
ENSG00000162144 E039 259.2404895 0.0021516016 6.778194e-02 1.396833e-01 11 61357733 61357828 96 - 2.348 2.303 -0.150
ENSG00000162144 E040 19.7562251 0.0065111124 8.716486e-01 9.214346e-01 11 61357829 61359425 1597 - 1.219 1.216 -0.008
ENSG00000162144 E041 6.6873644 0.0026088803 3.947082e-01 5.385440e-01 11 61359426 61359571 146 - 0.880 0.775 -0.408
ENSG00000162144 E042 43.8478403 0.0005299648 7.015829e-01 8.006859e-01 11 61359572 61361214 1643 - 1.560 1.549 -0.038
ENSG00000162144 E043 15.3718117 0.0012325604 7.177176e-01 8.130004e-01 11 61361215 61361304 90 - 1.071 1.122 0.184
ENSG00000162144 E044 221.2580720 0.0012418027 5.714684e-02 1.217176e-01 11 61361733 61361819 87 - 2.279 2.232 -0.155
ENSG00000162144 E045 221.4633869 0.0037424839 3.686636e-01 5.130742e-01 11 61361820 61362006 187 - 2.259 2.241 -0.061
ENSG00000162144 E046 229.3233384 0.0002305454 7.985454e-01 8.714573e-01 11 61362007 61362283 277 - 2.252 2.258 0.022