ENSG00000162129

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340729 ENSG00000162129 HEK293_OSMI2_2hA HEK293_TMG_2hB CLPB protein_coding protein_coding 27.13308 43.06567 16.91857 1.585634 1.085649 -1.347413 6.700253 11.844607 3.7608716 1.2058484 0.37939411 -1.6524779 0.2355583 0.2750000 0.22130000 -0.05370000 0.3975439559 3.129116e-11 FALSE TRUE
ENST00000535477 ENSG00000162129 HEK293_OSMI2_2hA HEK293_TMG_2hB CLPB protein_coding nonsense_mediated_decay 27.13308 43.06567 16.91857 1.585634 1.085649 -1.347413 3.996329 7.471275 1.6148941 0.4664843 0.84663253 -2.2029385 0.1349333 0.1732000 0.09156667 -0.08163333 0.6634125505 3.129116e-11 FALSE TRUE
ENST00000538021 ENSG00000162129 HEK293_OSMI2_2hA HEK293_TMG_2hB CLPB protein_coding nonsense_mediated_decay 27.13308 43.06567 16.91857 1.585634 1.085649 -1.347413 3.007986 8.338273 0.3712238 1.6410225 0.37122378 -4.4527678 0.0918375 0.1939333 0.02353333 -0.17040000 0.0557634464 3.129116e-11 FALSE TRUE
ENST00000538039 ENSG00000162129 HEK293_OSMI2_2hA HEK293_TMG_2hB CLPB protein_coding protein_coding 27.13308 43.06567 16.91857 1.585634 1.085649 -1.347413 4.161859 4.993739 3.4176839 0.7818390 0.05427333 -0.5457726 0.1685458 0.1155667 0.20326667 0.08770000 0.0181830651 3.129116e-11 FALSE TRUE
MSTRG.5923.3 ENSG00000162129 HEK293_OSMI2_2hA HEK293_TMG_2hB CLPB protein_coding   27.13308 43.06567 16.91857 1.585634 1.085649 -1.347413 6.320410 6.908729 6.3232190 0.9113282 0.32703012 -0.1275681 0.2641083 0.1607667 0.37720000 0.21643333 0.0002868233 3.129116e-11 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162129 E001 572.2903497 0.0149196998 1.294711e-03 4.958438e-03 11 72285495 72290552 5058 - 2.845 2.640 -0.684
ENSG00000162129 E002 107.1050659 0.0086632585 3.940049e-01 5.379098e-01 11 72290553 72290658 106 - 2.037 1.959 -0.264
ENSG00000162129 E003 126.7867570 0.0472076589 4.529874e-01 5.937913e-01 11 72290659 72290983 325 - 2.124 2.026 -0.328
ENSG00000162129 E004 685.1254033 0.0016928268 2.648461e-19 1.563550e-17 11 72290984 72293296 2313 - 2.940 2.708 -0.773
ENSG00000162129 E005 42.3690538 0.0004966643 8.455655e-08 8.706443e-07 11 72293297 72293299 3 - 1.795 1.475 -1.090
ENSG00000162129 E006 42.4703184 0.0005126305 1.709805e-07 1.660785e-06 11 72293300 72293302 3 - 1.792 1.478 -1.068
ENSG00000162129 E007 50.8234017 0.0004514288 1.381223e-06 1.112583e-05 11 72293303 72293308 6 - 1.844 1.572 -0.923
ENSG00000162129 E008 48.4521991 0.0004799957 5.243952e-04 2.250835e-03 11 72293309 72293309 1 - 1.785 1.575 -0.714
ENSG00000162129 E009 62.2959072 0.0003956965 5.596604e-03 1.754543e-02 11 72293310 72293322 13 - 1.859 1.700 -0.537
ENSG00000162129 E010 92.4598356 0.0003288704 8.500284e-01 9.069603e-01 11 72293323 72293344 22 - 1.936 1.914 -0.074
ENSG00000162129 E011 342.2998501 0.0002026298 3.787093e-09 5.044663e-08 11 72293345 72293615 271 - 2.407 2.508 0.337
ENSG00000162129 E012 296.4925684 0.0002221634 8.740223e-11 1.558702e-09 11 72294022 72294126 105 - 2.324 2.451 0.422
ENSG00000162129 E013 1.0631447 0.0121989077 6.536360e-02 1.356484e-01 11 72294127 72294324 198 - 0.000 0.358 12.642
ENSG00000162129 E014 201.4525021 0.0052753319 5.351636e-03 1.688739e-02 11 72294325 72294345 21 - 2.182 2.274 0.305
ENSG00000162129 E015 298.0131773 0.0002212849 3.118939e-08 3.496708e-07 11 72294346 72294444 99 - 2.343 2.445 0.340
ENSG00000162129 E016 0.9297165 0.0718623053 9.889986e-02 1.887958e-01 11 72294445 72294619 175 - 0.475 0.154 -2.219
ENSG00000162129 E017 147.0619267 0.0002564944 2.320634e-04 1.100248e-03 11 72294620 72294620 1 - 2.045 2.139 0.312
ENSG00000162129 E018 234.1768853 0.0004621816 5.602560e-04 2.385678e-03 11 72294621 72294693 73 - 2.270 2.335 0.216
ENSG00000162129 E019 3.2711095 0.1809966367 9.441026e-01 9.689643e-01 11 72294694 72295491 798 - 0.600 0.581 -0.083
ENSG00000162129 E020 316.0523740 0.0002991357 1.230404e-05 8.006057e-05 11 72295492 72295648 157 - 2.394 2.466 0.240
ENSG00000162129 E021 267.9065656 0.0001775298 1.117253e-05 7.341159e-05 11 72301803 72301964 162 - 2.318 2.397 0.261
ENSG00000162129 E022 1.2502363 0.0141441443 5.431569e-01 6.737917e-01 11 72301965 72302303 339 - 0.396 0.269 -0.794
ENSG00000162129 E023 98.6550776 0.0002899850 1.205059e-02 3.365444e-02 11 72302304 72302307 4 - 1.894 1.965 0.239
ENSG00000162129 E024 152.2335390 0.0005029217 3.919563e-03 1.291682e-02 11 72302308 72302348 41 - 2.084 2.151 0.223
ENSG00000162129 E025 1.4674297 0.0095938487 1.444738e-01 2.541118e-01 11 72302349 72302373 25 - 0.541 0.268 -1.534
ENSG00000162129 E026 1.8874188 0.0077054939 6.014998e-02 1.268590e-01 11 72303898 72304197 300 - 0.650 0.316 -1.699
ENSG00000162129 E027 159.7803618 0.0003029452 7.737094e-02 1.552606e-01 11 72307199 72307254 56 - 2.136 2.162 0.087
ENSG00000162129 E028 186.1785554 0.0013877661 6.448273e-02 1.341879e-01 11 72308527 72308604 78 - 2.197 2.230 0.108
ENSG00000162129 E029 0.0000000       11 72310944 72311051 108 -      
ENSG00000162129 E030 0.8846626 0.0135777423 5.668213e-01 6.937030e-01 11 72316503 72317105 603 - 0.175 0.268 0.788
ENSG00000162129 E031 186.2503677 0.0002467024 2.911780e-03 1.000468e-02 11 72317106 72317197 92 - 2.175 2.233 0.193
ENSG00000162129 E032 122.3897059 0.0019751809 8.285228e-02 1.640138e-01 11 72317198 72317220 23 - 2.007 2.047 0.133
ENSG00000162129 E033 183.6912086 0.0044304284 3.149540e-01 4.577065e-01 11 72329707 72329784 78 - 2.203 2.212 0.032
ENSG00000162129 E034 129.7751382 0.0044641410 5.201351e-01 6.541553e-01 11 72329785 72329804 20 - 2.061 2.058 -0.007
ENSG00000162129 E035 0.0000000       11 72332762 72332954 193 -      
ENSG00000162129 E036 0.0000000       11 72336615 72337126 512 -      
ENSG00000162129 E037 0.1482932 0.0413720133 1.000000e+00   11 72352448 72352566 119 - 0.000 0.084 9.992
ENSG00000162129 E038 0.0000000       11 72354267 72354307 41 -      
ENSG00000162129 E039 0.0000000       11 72354308 72354389 82 -      
ENSG00000162129 E040 0.1515154 0.0435780833 2.276787e-01   11 72356881 72357118 238 - 0.175 0.000 -12.716
ENSG00000162129 E041 234.0089158 0.0016586933 7.427427e-01 8.315675e-01 11 72358880 72359008 129 - 2.331 2.309 -0.071
ENSG00000162129 E042 0.0000000       11 72359138 72359206 69 -      
ENSG00000162129 E043 3.6975184 0.0043548530 4.421718e-02 9.878899e-02 11 72372925 72373014 90 - 0.842 0.525 -1.339
ENSG00000162129 E044 196.7308373 0.0002276163 5.529604e-01 6.821785e-01 11 72380281 72380384 104 - 2.275 2.228 -0.155
ENSG00000162129 E045 137.5609651 0.0005580553 1.095210e-01 2.048620e-01 11 72402966 72403038 73 - 2.147 2.063 -0.281
ENSG00000162129 E046 80.8186210 0.0020989766 1.189132e-02 3.327241e-02 11 72403039 72403052 14 - 1.960 1.813 -0.495
ENSG00000162129 E047 0.5514428 0.0198480088 2.814731e-01 4.213712e-01 11 72408098 72408204 107 - 0.000 0.215 11.627
ENSG00000162129 E048 19.4755701 0.0013681472 9.949476e-04 3.940582e-03 11 72428806 72429106 301 - 1.038 1.320 1.004
ENSG00000162129 E049 145.3517680 0.0038836806 8.176991e-01 8.847234e-01 11 72430312 72430363 52 - 2.139 2.097 -0.140
ENSG00000162129 E050 2.0596560 0.0618918928 3.397367e-01 4.836670e-01 11 72430364 72430494 131 - 0.299 0.470 0.978
ENSG00000162129 E051 138.5178964 0.0036271904 8.651125e-01 9.170940e-01 11 72434072 72434130 59 - 2.107 2.083 -0.079
ENSG00000162129 E052 320.9926059 0.0058543683 2.600327e-01 3.975115e-01 11 72434131 72434383 253 - 2.441 2.456 0.049
ENSG00000162129 E053 159.1910898 0.0012741218 3.996505e-02 9.096790e-02 11 72434384 72434680 297 - 2.118 2.160 0.139