ENSG00000162062

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361837 ENSG00000162062 HEK293_OSMI2_2hA HEK293_TMG_2hB TEDC2 protein_coding protein_coding 50.16519 78.13149 31.69983 4.720788 1.079203 -1.301159 6.268196 13.631899 2.7149949 2.6907035 0.47625302 -2.323719036 0.10215833 0.17176667 0.08676667 -0.085000000 0.0989357171 0.0001759523 FALSE  
ENST00000562253 ENSG00000162062 HEK293_OSMI2_2hA HEK293_TMG_2hB TEDC2 protein_coding retained_intron 50.16519 78.13149 31.69983 4.720788 1.079203 -1.301159 2.858722 1.779011 1.7816350 0.5629997 0.35886898 0.002114589 0.06593750 0.02286667 0.05600000 0.033133333 0.1851602650 0.0001759523 FALSE  
ENST00000563531 ENSG00000162062 HEK293_OSMI2_2hA HEK293_TMG_2hB TEDC2 protein_coding protein_coding 50.16519 78.13149 31.69983 4.720788 1.079203 -1.301159 2.937559 6.716893 1.5946459 3.4191838 1.59464594 -2.067685254 0.05857083 0.08743333 0.04756667 -0.039866667 0.5331983890 0.0001759523 FALSE  
ENST00000566580 ENSG00000162062 HEK293_OSMI2_2hA HEK293_TMG_2hB TEDC2 protein_coding retained_intron 50.16519 78.13149 31.69983 4.720788 1.079203 -1.301159 4.084617 2.818105 3.6671825 0.6980361 0.02331707 0.378765248 0.09778333 0.03573333 0.11593333 0.080200000 0.0001759523 0.0001759523    
ENST00000567489 ENSG00000162062 HEK293_OSMI2_2hA HEK293_TMG_2hB TEDC2 protein_coding protein_coding 50.16519 78.13149 31.69983 4.720788 1.079203 -1.301159 15.424773 24.455192 10.5900986 3.1570790 0.54617208 -1.206652916 0.30504167 0.31116667 0.33576667 0.024600000 0.8484884796 0.0001759523 FALSE  
ENST00000569496 ENSG00000162062 HEK293_OSMI2_2hA HEK293_TMG_2hB TEDC2 protein_coding protein_coding 50.16519 78.13149 31.69983 4.720788 1.079203 -1.301159 4.232359 5.137660 2.5681676 2.4246208 1.31833348 -0.997570792 0.08443750 0.06643333 0.08313333 0.016700000 0.9951183141 0.0001759523 FALSE  
ENST00000569994 ENSG00000162062 HEK293_OSMI2_2hA HEK293_TMG_2hB TEDC2 protein_coding retained_intron 50.16519 78.13149 31.69983 4.720788 1.079203 -1.301159 4.930588 7.750044 2.8625191 0.8136948 0.66965163 -1.433748443 0.09519167 0.09910000 0.09076667 -0.008333333 0.8780924252 0.0001759523 FALSE  
MSTRG.11864.2 ENSG00000162062 HEK293_OSMI2_2hA HEK293_TMG_2hB TEDC2 protein_coding   50.16519 78.13149 31.69983 4.720788 1.079203 -1.301159 2.112896 2.868445 0.8940115 2.8684453 0.89401151 -1.670876728 0.05454583 0.04073333 0.02666667 -0.014066667 0.9657223510 0.0001759523 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000162062 E001 0.2966881 0.0295703010 2.856900e-02   16 2460086 2460093 8 + 0.341 0.000 -12.179
ENSG00000162062 E002 2.1359325 0.0068246491 1.744962e-02 4.593273e-02 16 2460094 2460101 8 + 0.714 0.315 -1.973
ENSG00000162062 E003 3.8288834 0.0040780669 2.033095e-01 3.303432e-01 16 2460102 2460108 7 + 0.762 0.564 -0.844
ENSG00000162062 E004 9.7803448 0.0034548332 1.646697e-01 2.812519e-01 16 2460109 2460117 9 + 1.070 0.908 -0.600
ENSG00000162062 E005 38.0868375 0.0073029683 1.716671e-03 6.334350e-03 16 2460118 2460133 16 + 1.666 1.437 -0.784
ENSG00000162062 E006 64.5935755 0.0090891755 1.796697e-02 4.706372e-02 16 2460134 2460144 11 + 1.836 1.679 -0.528
ENSG00000162062 E007 78.7542703 0.0039806372 7.004138e-04 2.900483e-03 16 2460145 2460156 12 + 1.936 1.757 -0.606
ENSG00000162062 E008 95.0006335 0.0055855475 1.428994e-03 5.403564e-03 16 2460157 2460170 14 + 2.011 1.841 -0.571
ENSG00000162062 E009 36.0345140 0.0128762841 1.401305e-01 2.481961e-01 16 2460171 2460282 112 + 1.566 1.438 -0.438
ENSG00000162062 E010 165.5512034 0.0063090436 1.140829e-01 2.114743e-01 16 2460283 2460381 99 + 2.177 2.103 -0.246
ENSG00000162062 E011 66.0680329 0.0049231186 4.571376e-03 1.474074e-02 16 2460382 2460475 94 + 1.850 1.684 -0.563
ENSG00000162062 E012 81.4764804 0.0010528814 8.632489e-03 2.536733e-02 16 2460476 2460622 147 + 1.909 1.785 -0.417
ENSG00000162062 E013 282.7970413 0.0006572368 5.068485e-05 2.852502e-04 16 2460623 2460693 71 + 2.434 2.327 -0.357
ENSG00000162062 E014 17.4826082 0.0010897379 1.003732e-03 3.971469e-03 16 2460694 2460815 122 + 1.385 1.098 -1.014
ENSG00000162062 E015 452.3004797 0.0001439100 1.157862e-03 4.498082e-03 16 2460816 2460936 121 + 2.604 2.541 -0.212
ENSG00000162062 E016 684.0551782 0.0001477140 5.621625e-01 6.898249e-01 16 2460937 2461224 288 + 2.726 2.735 0.030
ENSG00000162062 E017 19.3562874 0.0113729393 3.066201e-05 1.820150e-04 16 2461225 2461449 225 + 1.489 1.100 -1.367
ENSG00000162062 E018 28.0107827 0.0219314537 7.752221e-07 6.595567e-06 16 2461547 2461746 200 + 1.688 1.221 -1.610
ENSG00000162062 E019 308.7865521 0.0001799310 3.410262e-01 4.849529e-01 16 2461747 2461800 54 + 2.408 2.385 -0.079
ENSG00000162062 E020 432.9467751 0.0001493737 7.236419e-01 8.174150e-01 16 2462149 2462239 91 + 2.529 2.535 0.023
ENSG00000162062 E021 427.1466582 0.0001427956 6.945313e-03 2.108097e-02 16 2462415 2462526 112 + 2.484 2.541 0.189
ENSG00000162062 E022 332.4536967 0.0017166239 6.445751e-05 3.532043e-04 16 2462631 2462732 102 + 2.320 2.445 0.420
ENSG00000162062 E023 311.5909921 0.0016761168 4.024896e-08 4.424163e-07 16 2464039 2464153 115 + 2.247 2.425 0.595
ENSG00000162062 E024 263.6195462 0.0001773606 1.199474e-04 6.137222e-04 16 2464154 2464229 76 + 2.233 2.340 0.355
ENSG00000162062 E025 238.5684826 0.0029179314 9.594332e-01 9.785343e-01 16 2464230 2464521 292 + 2.281 2.281 0.001
ENSG00000162062 E026 579.2377702 0.0008680485 3.029096e-07 2.800923e-06 16 2464522 2465320 799 + 2.570 2.684 0.382