ENSG00000161904

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000293760 ENSG00000161904 HEK293_OSMI2_2hA HEK293_TMG_2hB LEMD2 protein_coding protein_coding 46.16856 61.82945 28.70356 2.557566 0.1187988 -1.106795 15.835731 15.581218 14.882310 2.1036687 0.4707046 -0.06616611 0.3615917 0.2520000 0.51863333 0.2666333 2.037817e-05 8.138148e-06 FALSE TRUE
ENST00000421671 ENSG00000161904 HEK293_OSMI2_2hA HEK293_TMG_2hB LEMD2 protein_coding nonsense_mediated_decay 46.16856 61.82945 28.70356 2.557566 0.1187988 -1.106795 7.768419 14.743798 3.947028 0.6073422 0.2756953 -1.89859726 0.1621125 0.2385000 0.13756667 -0.1009333 8.138148e-06 8.138148e-06 FALSE TRUE
ENST00000506578 ENSG00000161904 HEK293_OSMI2_2hA HEK293_TMG_2hB LEMD2 protein_coding protein_coding 46.16856 61.82945 28.70356 2.557566 0.1187988 -1.106795 9.849523 19.780074 1.093932 2.1498508 1.0939317 -4.16405417 0.1869833 0.3202333 0.03803333 -0.2822000 4.431815e-02 8.138148e-06   FALSE
ENST00000508327 ENSG00000161904 HEK293_OSMI2_2hA HEK293_TMG_2hB LEMD2 protein_coding protein_coding 46.16856 61.82945 28.70356 2.557566 0.1187988 -1.106795 9.121089 8.192876 6.699176 0.5816242 0.9801470 -0.28999423 0.2094375 0.1322667 0.23323333 0.1009667 2.968963e-02 8.138148e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161904 E001 0.000000       6 33771202 33771212 11 -      
ENSG00000161904 E002 5.856246 0.0030823820 5.842483e-01 7.082059e-01 6 33771213 33771221 9 - 0.725 0.800 0.299
ENSG00000161904 E003 147.014646 0.0002777090 3.571596e-04 1.607919e-03 6 33771222 33771431 210 - 2.033 2.150 0.392
ENSG00000161904 E004 287.574326 0.0032632774 4.243636e-04 1.867770e-03 6 33771432 33771658 227 - 2.314 2.440 0.420
ENSG00000161904 E005 129.037503 0.0056300956 2.743084e-05 1.646815e-04 6 33771659 33771696 38 - 1.896 2.112 0.727
ENSG00000161904 E006 908.797976 0.0015810730 1.044353e-09 1.543409e-08 6 33771697 33772324 628 - 2.814 2.941 0.425
ENSG00000161904 E007 798.471982 0.0002059419 2.181051e-02 5.528117e-02 6 33772325 33772766 442 - 2.831 2.861 0.101
ENSG00000161904 E008 164.510842 0.0002065512 4.937139e-01 6.307200e-01 6 33772767 33772775 9 - 2.185 2.162 -0.077
ENSG00000161904 E009 148.499706 0.0002230685 2.502110e-01 3.861899e-01 6 33772776 33772778 3 - 2.151 2.112 -0.130
ENSG00000161904 E010 11.164295 0.0015226844 3.298463e-03 1.114491e-02 6 33776614 33776953 340 - 1.226 0.930 -1.074
ENSG00000161904 E011 234.741518 0.0001815994 7.880997e-01 8.642976e-01 6 33776954 33777011 58 - 2.319 2.324 0.014
ENSG00000161904 E012 189.447247 0.0004353710 5.406227e-01 6.717300e-01 6 33777012 33777034 23 - 2.219 2.234 0.053
ENSG00000161904 E013 187.579916 0.0008416710 5.382771e-01 6.697193e-01 6 33777035 33777056 22 - 2.214 2.231 0.058
ENSG00000161904 E014 184.201759 0.0013040606 8.856629e-01 9.308664e-01 6 33777138 33777153 16 - 2.221 2.215 -0.020
ENSG00000161904 E015 324.612494 0.0001698991 5.236632e-02 1.133749e-01 6 33777154 33777239 86 - 2.494 2.450 -0.146
ENSG00000161904 E016 270.449060 0.0001827413 2.768082e-01 4.162835e-01 6 33778242 33778318 77 - 2.404 2.376 -0.093
ENSG00000161904 E017 160.514455 0.0002483174 1.579799e-01 2.724446e-01 6 33778319 33778330 12 - 2.190 2.145 -0.152
ENSG00000161904 E018 236.641384 0.0001965529 2.467204e-01 3.820911e-01 6 33778331 33778387 57 - 2.348 2.317 -0.105
ENSG00000161904 E019 14.439803 0.0021231319 6.371585e-01 7.510952e-01 6 33778388 33780001 1614 - 1.173 1.126 -0.168
ENSG00000161904 E020 3.176263 0.0052373597 1.615350e-01 2.771021e-01 6 33780002 33780099 98 - 0.726 0.507 -0.965
ENSG00000161904 E021 249.538680 0.0003732084 2.237915e-01 3.549409e-01 6 33780100 33780179 80 - 2.373 2.340 -0.110
ENSG00000161904 E022 0.000000       6 33780180 33780299 120 -      
ENSG00000161904 E023 208.606277 0.0001879698 9.981938e-01 1.000000e+00 6 33781077 33781153 77 - 2.273 2.270 -0.009
ENSG00000161904 E024 4.829444 0.0035248015 2.336847e-01 3.667644e-01 6 33781154 33781356 203 - 0.588 0.768 0.756
ENSG00000161904 E025 8.451254 0.0021342409 9.620995e-01 9.800984e-01 6 33781357 33782246 890 - 0.938 0.930 -0.030
ENSG00000161904 E026 166.277126 0.0004736632 4.155851e-01 5.589492e-01 6 33784352 33784427 76 - 2.193 2.165 -0.092
ENSG00000161904 E027 16.640845 0.0010842257 4.422727e-01 5.839357e-01 6 33784428 33784669 242 - 1.250 1.180 -0.247
ENSG00000161904 E028 124.171229 0.0002851403 1.347930e-03 5.135989e-03 6 33786734 33786774 41 - 2.125 2.014 -0.371
ENSG00000161904 E029 22.601785 0.0008923264 1.617993e-06 1.284139e-05 6 33786775 33786873 99 - 1.545 1.193 -1.223
ENSG00000161904 E030 37.327508 0.0041279984 5.960341e-07 5.195163e-06 6 33786874 33787097 224 - 1.738 1.413 -1.112
ENSG00000161904 E031 181.375066 0.0110348949 2.649069e-07 2.479169e-06 6 33788381 33788774 394 - 2.400 2.110 -0.968
ENSG00000161904 E032 146.837244 0.0394884933 3.709307e-04 1.661990e-03 6 33788775 33789130 356 - 2.336 1.997 -1.133