ENSG00000161888

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000585486 ENSG00000161888 HEK293_OSMI2_2hA HEK293_TMG_2hB SPC24 protein_coding protein_coding 54.3601 93.14507 25.00795 2.141593 0.7689008 -1.896671 7.854018 10.50536 4.900204 1.5045929 0.1717763 -1.0986437 0.1555250 0.1121667 0.1967667 0.084600000 0.01443566 0.01443566 FALSE TRUE
ENST00000592540 ENSG00000161888 HEK293_OSMI2_2hA HEK293_TMG_2hB SPC24 protein_coding protein_coding 54.3601 93.14507 25.00795 2.141593 0.7689008 -1.896671 27.849572 52.14703 10.345718 0.4854097 0.6928975 -2.3324340 0.4833250 0.5602667 0.4161333 -0.144133333 0.04431667 0.01443566 FALSE TRUE
ENST00000592967 ENSG00000161888 HEK293_OSMI2_2hA HEK293_TMG_2hB SPC24 protein_coding protein_coding 54.3601 93.14507 25.00795 2.141593 0.7689008 -1.896671 2.693688 2.72814 1.646477 0.8227557 0.3443522 -0.7250774 0.0602500 0.0291000 0.0667000 0.037600000 0.19979097 0.01443566 FALSE TRUE
MSTRG.16439.4 ENSG00000161888 HEK293_OSMI2_2hA HEK293_TMG_2hB SPC24 protein_coding   54.3601 93.14507 25.00795 2.141593 0.7689008 -1.896671 12.429583 22.32454 5.902194 1.4993060 1.5440018 -1.9175113 0.2278167 0.2401000 0.2333333 -0.006766667 0.94720912 0.01443566 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161888 E001 9.808407 0.0018314086 4.286375e-04 1.884610e-03 19 11131520 11131607 88 - 1.212 0.805 -1.508
ENSG00000161888 E002 3.460366 0.0322965380 6.709350e-04 2.792325e-03 19 11137312 11137415 104 - 0.955 0.390 -2.459
ENSG00000161888 E003 264.848065 0.0003103669 4.169518e-02 9.417843e-02 19 11145493 11145922 430 - 2.217 2.277 0.200
ENSG00000161888 E004 102.127082 0.0007030024 2.170378e-02 5.506075e-02 19 11145923 11145949 27 - 1.757 1.872 0.388
ENSG00000161888 E005 293.845248 0.0006122001 1.058214e-03 4.160451e-03 19 11145950 11146021 72 - 2.229 2.328 0.331
ENSG00000161888 E006 782.573741 0.0008948776 1.728541e-01 2.919149e-01 19 11146022 11146279 258 - 2.716 2.742 0.084
ENSG00000161888 E007 546.343053 0.0010635440 1.287585e-01 2.324285e-01 19 11146280 11146430 151 - 2.552 2.587 0.117
ENSG00000161888 E008 780.153813 0.0001423152 3.414087e-17 1.554780e-15 19 11146431 11147080 650 - 2.605 2.755 0.500
ENSG00000161888 E009 220.938451 0.0002967598 8.589008e-03 2.526139e-02 19 11147081 11147133 53 - 2.114 2.200 0.289
ENSG00000161888 E010 348.162158 0.0001598851 7.909605e-02 1.580678e-01 19 11147134 11147289 156 - 2.426 2.379 -0.159
ENSG00000161888 E011 67.404712 0.0066510592 4.181105e-04 1.843803e-03 19 11147599 11147817 219 - 1.864 1.634 -0.778
ENSG00000161888 E012 221.095101 0.0002098917 1.004617e-02 2.887556e-02 19 11147818 11147869 52 - 2.259 2.175 -0.281
ENSG00000161888 E013 179.131558 0.0008898673 4.920699e-06 3.507060e-05 19 11147870 11147894 25 - 2.236 2.071 -0.553
ENSG00000161888 E014 319.938049 0.0001978622 1.556279e-07 1.523445e-06 19 11148013 11148117 105 - 2.463 2.327 -0.453
ENSG00000161888 E015 417.228130 0.0012730582 2.694414e-06 2.038045e-05 19 11149094 11149238 145 - 2.570 2.442 -0.427
ENSG00000161888 E016 8.348306 0.1137323599 4.694656e-01 6.087075e-01 19 11149239 11149351 113 - 0.667 0.844 0.711
ENSG00000161888 E017 311.167223 0.0031078237 6.482027e-02 1.347467e-01 19 11155617 11155807 191 - 2.396 2.325 -0.234