ENSG00000161813

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398473 ENSG00000161813 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP4 protein_coding protein_coding 21.32123 5.359391 37.66239 0.3545993 1.860733 2.810677 7.1082183 2.36786056 12.8297337 0.34776939 0.92015736 2.432879 0.40717083 0.45326667 0.341800000 -0.1114667 6.115831e-01 1.057124e-10 FALSE TRUE
ENST00000429001 ENSG00000161813 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP4 protein_coding protein_coding 21.32123 5.359391 37.66239 0.3545993 1.860733 2.810677 1.5914376 0.00000000 2.9588606 0.00000000 0.34012566 8.213766 0.06052917 0.00000000 0.078100000 0.0781000 1.057124e-10 1.057124e-10 FALSE TRUE
ENST00000518444 ENSG00000161813 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP4 protein_coding protein_coding 21.32123 5.359391 37.66239 0.3545993 1.860733 2.810677 1.1669110 0.65569793 2.7760902 0.52550850 0.58860120 2.065302 0.05020000 0.11136667 0.072866667 -0.0385000 9.253806e-01 1.057124e-10 FALSE TRUE
ENST00000520064 ENSG00000161813 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP4 protein_coding protein_coding 21.32123 5.359391 37.66239 0.3545993 1.860733 2.810677 0.3304355 0.76441313 0.1841095 0.53627614 0.09207368 -1.996233 0.03976250 0.14003333 0.004666667 -0.1353667 3.391411e-01 1.057124e-10 FALSE TRUE
ENST00000522085 ENSG00000161813 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP4 protein_coding protein_coding 21.32123 5.359391 37.66239 0.3545993 1.860733 2.810677 2.8713952 0.08597028 4.5571120 0.08597028 0.61654057 5.572551 0.08728333 0.01436667 0.123000000 0.1086333 3.460871e-02 1.057124e-10 FALSE TRUE
MSTRG.7284.8 ENSG00000161813 HEK293_OSMI2_2hA HEK293_TMG_2hB LARP4 protein_coding   21.32123 5.359391 37.66239 0.3545993 1.860733 2.810677 3.6407059 0.37609657 5.9103400 0.10489348 0.51619374 3.938646 0.13913333 0.07340000 0.157600000 0.0842000 1.039495e-01 1.057124e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161813 E001 0.0000000       12 50392383 50392588 206 +      
ENSG00000161813 E002 0.0000000       12 50400809 50400856 48 +      
ENSG00000161813 E003 2.6625907 0.0057118234 2.766008e-01 4.160538e-01 12 50400857 50400884 28 + 0.464 0.288 -1.021
ENSG00000161813 E004 6.0604935 0.0026794007 5.058116e-01 6.415385e-01 12 50400885 50400888 4 + 0.703 0.678 -0.103
ENSG00000161813 E005 7.0978069 0.0025227218 2.934019e-01 4.344545e-01 12 50400889 50400894 6 + 0.766 0.678 -0.360
ENSG00000161813 E006 7.2429795 0.0029176528 2.710374e-01 4.097354e-01 12 50400895 50400895 1 + 0.774 0.678 -0.393
ENSG00000161813 E007 11.9715504 0.0014270756 3.818596e-02 8.770340e-02 12 50400896 50400907 12 + 0.975 0.757 -0.840
ENSG00000161813 E008 26.3929515 0.0007275335 7.870444e-02 1.574380e-01 12 50400908 50400928 21 + 1.276 1.206 -0.246
ENSG00000161813 E009 27.2766731 0.0007096612 5.474434e-02 1.175494e-01 12 50400929 50400931 3 + 1.291 1.206 -0.300
ENSG00000161813 E010 33.9352351 0.0005722645 1.933955e-02 5.006860e-02 12 50400932 50400949 18 + 1.383 1.276 -0.372
ENSG00000161813 E011 40.3713078 0.0005576975 1.971983e-03 7.138774e-03 12 50400950 50400955 6 + 1.461 1.298 -0.565
ENSG00000161813 E012 57.1426902 0.0004142044 2.533341e-03 8.863371e-03 12 50400956 50400984 29 + 1.601 1.493 -0.368
ENSG00000161813 E013 57.9849564 0.0004131954 1.546845e-02 4.155548e-02 12 50400985 50401000 16 + 1.601 1.543 -0.198
ENSG00000161813 E014 60.8508945 0.0003983962 2.214796e-02 5.598398e-02 12 50401001 50401028 28 + 1.620 1.577 -0.148
ENSG00000161813 E015 1.6326496 0.0100298506 1.801167e-01 3.013137e-01 12 50401108 50401192 85 + 0.252 0.583 1.845
ENSG00000161813 E016 1.7841651 0.0134183881 2.352493e-01 3.686536e-01 12 50401193 50401221 29 + 0.279 0.583 1.653
ENSG00000161813 E017 0.1482932 0.0414783308 5.543572e-02   12 50401222 50401281 60 + 0.000 0.288 32.192
ENSG00000161813 E018 5.4368382 0.0030107060 5.416611e-01 6.726188e-01 12 50402675 50402813 139 + 0.629 0.823 0.794
ENSG00000161813 E019 19.8903071 0.0008806791 3.340082e-02 7.857647e-02 12 50412405 50412453 49 + 1.168 1.018 -0.542
ENSG00000161813 E020 1.1135859 0.0112619016 1.000000e+00 1.000000e+00 12 50412454 50412457 4 + 0.224 0.288 0.483
ENSG00000161813 E021 0.9058703 0.7046335291 6.288632e-01 7.443305e-01 12 50415712 50415831 120 + 0.196 0.281 0.678
ENSG00000161813 E022 1.9219654 0.0073672175 5.173419e-01 6.517501e-01 12 50416346 50416434 89 + 0.371 0.288 -0.519
ENSG00000161813 E023 5.0878019 0.0037091989 3.443907e-02 8.060161e-02 12 50420788 50420887 100 + 0.673 0.288 -1.977
ENSG00000161813 E024 46.7692349 0.0007130946 1.764716e-02 4.637538e-02 12 50427762 50427764 3 + 1.513 1.437 -0.260
ENSG00000161813 E025 124.7884883 0.0175013724 1.318389e-02 3.634001e-02 12 50427765 50427909 145 + 1.932 1.845 -0.290
ENSG00000161813 E026 4.3413395 0.0041456415 6.676026e-02 1.380057e-01 12 50428917 50428934 18 + 0.618 0.288 -1.741
ENSG00000161813 E027 122.4415698 0.0013378871 3.449830e-05 2.020528e-04 12 50428935 50429090 156 + 1.926 1.820 -0.359
ENSG00000161813 E028 0.1515154 0.0427598989 8.624303e-01   12 50429091 50429091 1 + 0.046 0.000 -26.338
ENSG00000161813 E029 51.9272622 0.0116251619 9.595563e-03 2.776891e-02 12 50430495 50430497 3 + 1.563 1.425 -0.473
ENSG00000161813 E030 87.4880884 0.0017446061 1.793568e-03 6.579265e-03 12 50430498 50430570 73 + 1.779 1.699 -0.271
ENSG00000161813 E031 144.7963892 0.0066625981 4.562460e-02 1.013430e-01 12 50435488 50435624 137 + 1.988 1.980 -0.027
ENSG00000161813 E032 147.9641860 0.0021239282 1.917375e-02 4.971817e-02 12 50437735 50437838 104 + 1.996 1.996 -0.001
ENSG00000161813 E033 104.0919083 0.0002815247 8.565645e-03 2.520402e-02 12 50440439 50440478 40 + 1.848 1.826 -0.076
ENSG00000161813 E034 110.5686817 0.0002508213 6.860453e-02 1.410532e-01 12 50440479 50440549 71 + 1.868 1.893 0.084
ENSG00000161813 E035 94.3477342 0.0003160701 2.496730e-01 3.855323e-01 12 50441590 50441643 54 + 1.796 1.849 0.181
ENSG00000161813 E036 169.3767565 0.0016877037 1.216979e-01 2.223592e-01 12 50453460 50453672 213 + 2.049 2.095 0.156
ENSG00000161813 E037 140.1061820 0.0067382755 2.122741e-02 5.406768e-02 12 50454314 50454417 104 + 1.975 1.950 -0.086
ENSG00000161813 E038 5.2778541 0.0031592101 6.304937e-06 4.387817e-05 12 50454418 50454962 545 + 0.464 1.180 2.887
ENSG00000161813 E039 5.2100141 0.0760549212 5.742912e-04 2.437717e-03 12 50455507 50455583 77 + 0.481 1.174 2.781
ENSG00000161813 E040 201.8979517 0.0015464917 1.477199e-05 9.441985e-05 12 50461135 50461347 213 + 2.137 2.068 -0.231
ENSG00000161813 E041 1.5544000 0.3798279189 3.187314e-01 4.617050e-01 12 50461348 50461487 140 + 0.224 0.603 2.155
ENSG00000161813 E042 96.6418689 0.0003386020 1.124489e-01 2.091104e-01 12 50462582 50462630 49 + 1.807 1.838 0.103
ENSG00000161813 E043 141.1245411 0.0002655560 1.753317e-02 4.611135e-02 12 50466959 50467120 162 + 1.973 1.983 0.034
ENSG00000161813 E044 114.8358630 0.0002556490 1.435922e-02 3.904511e-02 12 50473415 50473536 122 + 1.888 1.883 -0.019
ENSG00000161813 E045 101.4570170 0.0006751421 6.387520e-02 1.331488e-01 12 50473999 50474107 109 + 1.832 1.849 0.059
ENSG00000161813 E046 92.4396302 0.0008346598 4.125168e-01 5.560699e-01 12 50474108 50474167 60 + 1.785 1.855 0.238
ENSG00000161813 E047 1620.3945976 0.0103931645 1.176927e-07 1.179961e-06 12 50475526 50480004 4479 + 2.986 3.261 0.914