ENSG00000161800

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312377 ENSG00000161800 HEK293_OSMI2_2hA HEK293_TMG_2hB RACGAP1 protein_coding protein_coding 42.39623 25.80847 58.3243 3.763432 1.82704 1.175941 15.890167 11.0139716 22.513682 1.2355794 0.3362858 1.0307986 0.38533750 0.4313000 0.3864667 -0.04483333 0.385079666 0.008095189 FALSE TRUE
ENST00000454520 ENSG00000161800 HEK293_OSMI2_2hA HEK293_TMG_2hB RACGAP1 protein_coding protein_coding 42.39623 25.80847 58.3243 3.763432 1.82704 1.175941 13.454040 10.3534982 15.261584 2.3861172 1.3468352 0.5593386 0.33092917 0.3913667 0.2616000 -0.12976667 0.049837758 0.008095189 FALSE TRUE
MSTRG.7269.6 ENSG00000161800 HEK293_OSMI2_2hA HEK293_TMG_2hB RACGAP1 protein_coding   42.39623 25.80847 58.3243 3.763432 1.82704 1.175941 3.312909 0.7986055 4.573739 0.1918808 0.2994473 2.5030171 0.06886667 0.0319000 0.0783000 0.04640000 0.008095189 0.008095189 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161800 E001 5.8061804 0.0583123308 1.311980e-01 2.358255e-01 12 49976923 49977059 137 - 0.699 0.991 1.138
ENSG00000161800 E002 1.8412335 0.0079437314 1.156766e-01 2.137892e-01 12 49989162 49989163 2 - 0.337 0.618 1.421
ENSG00000161800 E003 592.0369395 0.0021285148 4.991724e-17 2.223007e-15 12 49989164 49989873 710 - 2.660 2.895 0.782
ENSG00000161800 E004 138.4409974 0.0080855004 1.187817e-05 7.757727e-05 12 49989874 49989894 21 - 2.024 2.274 0.836
ENSG00000161800 E005 223.3659215 0.0054108942 1.896799e-07 1.825558e-06 12 49989895 49989978 84 - 2.235 2.475 0.801
ENSG00000161800 E006 208.1693060 0.0030233687 5.272617e-10 8.224631e-09 12 49989979 49990021 43 - 2.205 2.447 0.807
ENSG00000161800 E007 468.3727274 0.0006940878 3.233047e-14 9.866159e-13 12 49990022 49990267 246 - 2.592 2.765 0.578
ENSG00000161800 E008 267.8824610 0.0001756276 1.220389e-02 3.402010e-02 12 49990268 49990343 76 - 2.394 2.472 0.260
ENSG00000161800 E009 291.2332528 0.0001920303 5.158298e-01 6.504420e-01 12 49990684 49990792 109 - 2.448 2.484 0.121
ENSG00000161800 E010 247.6674286 0.0038380065 7.877632e-01 8.640488e-01 12 49991998 49992078 81 - 2.376 2.410 0.114
ENSG00000161800 E011 176.8158888 0.0040296335 2.977112e-01 4.390639e-01 12 49992079 49992133 55 - 2.218 2.283 0.219
ENSG00000161800 E012 293.2346503 0.0005411866 3.173336e-01 4.601905e-01 12 49992245 49992377 133 - 2.464 2.462 -0.007
ENSG00000161800 E013 278.6720070 0.0002138017 8.897471e-01 9.335321e-01 12 49992550 49992655 106 - 2.434 2.453 0.063
ENSG00000161800 E014 360.9468226 0.0010951288 4.388316e-01 5.806683e-01 12 49994131 49994329 199 - 2.551 2.550 -0.006
ENSG00000161800 E015 232.4793889 0.0002139951 3.197396e-02 7.581001e-02 12 49994414 49994509 96 - 2.373 2.341 -0.105
ENSG00000161800 E016 130.8129390 0.0026380318 9.227938e-01 9.553190e-01 12 49997040 49997068 29 - 2.108 2.122 0.048
ENSG00000161800 E017 163.1523494 0.0006379103 5.987654e-01 7.202956e-01 12 49997069 49997130 62 - 2.194 2.231 0.121
ENSG00000161800 E018 138.7982861 0.0016512757 5.037790e-01 6.397178e-01 12 49997131 49997159 29 - 2.140 2.134 -0.021
ENSG00000161800 E019 145.5290214 0.0002577547 5.259003e-01 6.592153e-01 12 49997160 49997204 45 - 2.158 2.160 0.007
ENSG00000161800 E020 0.2934659 0.0280839896 6.602634e-01   12 49999139 49999140 2 - 0.092 0.161 0.937
ENSG00000161800 E021 247.0045902 0.0006822992 3.779812e-02 8.696130e-02 12 49999141 49999271 131 - 2.401 2.366 -0.115
ENSG00000161800 E022 2.4668605 0.0070099126 5.735636e-02 1.220870e-01 12 49999310 49999615 306 - 0.382 0.704 1.523
ENSG00000161800 E023 198.1140626 0.0016483691 3.979825e-01 5.417200e-01 12 49999616 49999674 59 - 2.296 2.285 -0.036
ENSG00000161800 E024 181.7434970 0.0005848380 2.928967e-02 7.056451e-02 12 49999675 49999733 59 - 2.271 2.227 -0.146
ENSG00000161800 E025 0.3289534 0.0269875857 6.550216e-01   12 49999734 49999736 3 - 0.092 0.162 0.939
ENSG00000161800 E026 0.6256415 0.0176026538 6.753798e-01 7.806890e-01 12 50001171 50001171 1 - 0.232 0.162 -0.646
ENSG00000161800 E027 195.1560323 0.0004230427 3.077933e-03 1.049524e-02 12 50001172 50001252 81 - 2.308 2.247 -0.206
ENSG00000161800 E028 8.1594234 0.0040878007 6.623524e-01 7.706758e-01 12 50001941 50002037 97 - 0.931 1.000 0.259
ENSG00000161800 E029 4.0243981 0.0039075008 9.272889e-01 9.582305e-01 12 50002038 50002060 23 - 0.699 0.703 0.020
ENSG00000161800 E030 113.6649577 0.0003500493 5.304278e-03 1.675944e-02 12 50002247 50002247 1 - 2.081 2.004 -0.257
ENSG00000161800 E031 133.9694796 0.0011250803 8.960171e-03 2.617989e-02 12 50002248 50002271 24 - 2.149 2.076 -0.245
ENSG00000161800 E032 120.5500727 0.0005015037 8.281491e-04 3.359968e-03 12 50002272 50002300 29 - 2.112 2.016 -0.322
ENSG00000161800 E033 0.8417882 0.0161027590 2.686535e-01 4.071387e-01 12 50002631 50002691 61 - 0.167 0.371 1.525
ENSG00000161800 E034 0.2924217 0.0271525899 4.404081e-01   12 50004234 50004234 1 - 0.167 0.000 -10.173
ENSG00000161800 E035 114.8824515 0.0004688173 2.851247e-03 9.827171e-03 12 50004235 50004264 30 - 2.087 2.002 -0.286
ENSG00000161800 E036 72.9784685 0.0014018446 1.621291e-01 2.778998e-01 12 50004265 50004277 13 - 1.878 1.833 -0.152
ENSG00000161800 E037 107.0840002 0.0089651508 2.518771e-01 3.881764e-01 12 50004278 50004304 27 - 2.047 1.984 -0.212
ENSG00000161800 E038 111.1577994 0.0053019087 1.102179e-01 2.058667e-01 12 50005256 50005263 8 - 2.066 1.995 -0.237
ENSG00000161800 E039 147.4021390 0.0047412979 2.679925e-03 9.313443e-03 12 50005264 50005290 27 - 2.207 2.079 -0.428
ENSG00000161800 E040 127.7710385 0.0068123609 1.352640e-04 6.823787e-04 12 50005291 50005293 3 - 2.165 1.972 -0.646
ENSG00000161800 E041 197.5964958 0.0011647446 7.632972e-06 5.208528e-05 12 50005294 50005346 53 - 2.334 2.212 -0.405
ENSG00000161800 E042 146.3310407 0.0006555443 1.260355e-03 4.844689e-03 12 50005347 50005357 11 - 2.193 2.109 -0.281
ENSG00000161800 E043 162.7155694 0.0002802220 2.894835e-06 2.173501e-05 12 50005358 50005392 35 - 2.251 2.134 -0.392
ENSG00000161800 E044 319.9713912 0.0001856703 2.324255e-11 4.561516e-10 12 50006434 50006636 203 - 2.543 2.422 -0.404
ENSG00000161800 E045 111.0290676 0.0003231820 1.523434e-03 5.713013e-03 12 50016631 50016634 4 - 2.076 1.984 -0.306
ENSG00000161800 E046 190.4616457 0.0001929484 1.955849e-06 1.524751e-05 12 50016635 50016715 81 - 2.314 2.206 -0.361
ENSG00000161800 E047 97.7367709 0.0002785059 1.013288e-05 6.724264e-05 12 50016716 50016719 4 - 2.039 1.892 -0.493
ENSG00000161800 E048 0.5149111 0.0204169418 2.758884e-01 4.152849e-01 12 50016720 50016720 1 - 0.092 0.279 1.939
ENSG00000161800 E049 0.2987644 0.0290785164 4.401731e-01   12 50016940 50017084 145 - 0.167 0.000 -10.173
ENSG00000161800 E050 9.0173772 0.0018135360 1.896423e-03 6.903404e-03 12 50018516 50018589 74 - 1.098 0.741 -1.354
ENSG00000161800 E051 0.4482035 0.0306313705 2.368462e-01 3.705300e-01 12 50019744 50019806 63 - 0.232 0.000 -10.758
ENSG00000161800 E052 3.1684304 0.0784701912 2.313363e-02 5.802838e-02 12 50021062 50021177 116 - 0.739 0.278 -2.319
ENSG00000161800 E053 41.4492640 0.0005180014 4.229310e-01 5.660683e-01 12 50025328 50025372 45 - 1.632 1.609 -0.078
ENSG00000161800 E054 44.9344399 0.0005039116 2.312253e-01 3.639403e-01 12 50025373 50025397 25 - 1.675 1.632 -0.145
ENSG00000161800 E055 104.2547722 0.0003448581 1.468744e-07 1.444474e-06 12 50025398 50025450 53 - 2.074 1.897 -0.593
ENSG00000161800 E056 16.8886553 0.0245648868 1.763180e-01 2.964563e-01 12 50025451 50025557 107 - 1.291 1.137 -0.546
ENSG00000161800 E057 0.0000000       12 50031697 50031867 171 -      
ENSG00000161800 E058 0.0000000       12 50032970 50033136 167 -