ENSG00000161647

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398389 ENSG00000161647 HEK293_OSMI2_2hA HEK293_TMG_2hB MPP3 protein_coding protein_coding 9.594823 9.153687 8.495822 0.690636 0.6831141 -0.1074776 0.5175105 0.4165606 0.5517099 0.09541897 0.01776335 0.39707456 0.05500833 0.04646667 0.06603333 0.019566667 5.982509e-01 8.741112e-05 FALSE TRUE
ENST00000466083 ENSG00000161647 HEK293_OSMI2_2hA HEK293_TMG_2hB MPP3 protein_coding retained_intron 9.594823 9.153687 8.495822 0.690636 0.6831141 -0.1074776 1.8754586 0.5339605 1.5585682 0.28234167 0.50066697 1.52787446 0.18812500 0.05616667 0.17773333 0.121566667 4.058238e-01 8.741112e-05 FALSE FALSE
ENST00000480958 ENSG00000161647 HEK293_OSMI2_2hA HEK293_TMG_2hB MPP3 protein_coding retained_intron 9.594823 9.153687 8.495822 0.690636 0.6831141 -0.1074776 2.7601252 4.0223395 2.3007353 0.19756572 0.07494788 -0.80326509 0.29487500 0.44116667 0.27310000 -0.168066667 8.741112e-05 8.741112e-05 FALSE TRUE
ENST00000486600 ENSG00000161647 HEK293_OSMI2_2hA HEK293_TMG_2hB MPP3 protein_coding retained_intron 9.594823 9.153687 8.495822 0.690636 0.6831141 -0.1074776 1.1765321 0.9121164 1.1475781 0.08422541 0.26002570 0.32808879 0.11763333 0.10060000 0.13356667 0.032966667 6.242215e-01 8.741112e-05   FALSE
ENST00000496503 ENSG00000161647 HEK293_OSMI2_2hA HEK293_TMG_2hB MPP3 protein_coding nonsense_mediated_decay 9.594823 9.153687 8.495822 0.690636 0.6831141 -0.1074776 2.5892313 2.8178146 2.6546341 0.20961556 0.16393161 -0.08575008 0.27440833 0.30850000 0.31413333 0.005633333 9.773984e-01 8.741112e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161647 E001 0.0000000       17 43800799 43800810 12 -      
ENSG00000161647 E002 10.0940153 0.0066664026 6.675152e-02 1.379954e-01 17 43800811 43801417 607 - 1.144 0.945 -0.727
ENSG00000161647 E003 8.1789955 0.0020767706 5.815735e-01 7.061041e-01 17 43801418 43801487 70 - 0.915 0.971 0.212
ENSG00000161647 E004 43.7482906 0.0205674045 5.867616e-01 7.102527e-01 17 43801488 43801693 206 - 1.668 1.622 -0.159
ENSG00000161647 E005 47.4062300 0.0161956262 6.559555e-01 7.657346e-01 17 43801694 43801877 184 - 1.696 1.660 -0.123
ENSG00000161647 E006 21.2960074 0.0014682617 6.208549e-01 7.379096e-01 17 43808956 43808999 44 - 1.355 1.312 -0.150
ENSG00000161647 E007 27.9814090 0.0009084026 8.446675e-01 9.033364e-01 17 43809000 43809078 79 - 1.441 1.448 0.024
ENSG00000161647 E008 28.5206446 0.0007391294 8.032637e-01 8.747609e-01 17 43810807 43810915 109 - 1.447 1.456 0.033
ENSG00000161647 E009 21.9868214 0.0045654932 9.298012e-01 9.598041e-01 17 43811112 43811156 45 - 1.355 1.341 -0.050
ENSG00000161647 E010 24.4933079 0.0026866372 7.716723e-01 8.526096e-01 17 43811157 43811205 49 - 1.383 1.397 0.049
ENSG00000161647 E011 14.3048456 0.0012347179 7.319130e-02 1.486287e-01 17 43811206 43811571 366 - 1.267 1.104 -0.578
ENSG00000161647 E012 26.3547255 0.0007245323 9.950788e-01 1.000000e+00 17 43814011 43814091 81 - 1.423 1.417 -0.021
ENSG00000161647 E013 31.0900573 0.0007754205 2.653565e-01 4.034040e-01 17 43814197 43814361 165 - 1.532 1.457 -0.260
ENSG00000161647 E014 5.3800412 0.0030175148 3.821252e-03 1.263923e-02 17 43814362 43814394 33 - 0.989 0.609 -1.511
ENSG00000161647 E015 9.2560047 0.0019894913 5.579182e-04 2.377166e-03 17 43814601 43814634 34 - 1.189 0.818 -1.373
ENSG00000161647 E016 17.7688450 0.0179770926 1.698466e-01 2.880141e-01 17 43816038 43816079 42 - 1.333 1.194 -0.487
ENSG00000161647 E017 1.3016330 0.0630199439 8.727610e-02 1.710040e-01 17 43816677 43816697 21 - 0.516 0.193 -2.026
ENSG00000161647 E018 0.3666179 0.0280383374 8.302895e-01 8.935132e-01 17 43817919 43818045 127 - 0.140 0.107 -0.444
ENSG00000161647 E019 17.3312401 0.0297881425 1.258522e-01 2.283614e-01 17 43818046 43818110 65 - 1.341 1.172 -0.595
ENSG00000161647 E020 1.4350506 0.0094798327 1.534531e-01 2.663664e-01 17 43819000 43819081 82 - 0.516 0.264 -1.447
ENSG00000161647 E021 29.3066032 0.0171232264 5.013344e-02 1.094021e-01 17 43820862 43821058 197 - 1.560 1.389 -0.589
ENSG00000161647 E022 25.6724589 0.0008696603 2.077828e-01 3.358086e-01 17 43823931 43824005 75 - 1.464 1.373 -0.316
ENSG00000161647 E023 76.9156228 0.0004017999 5.656043e-06 3.977285e-05 17 43825041 43825622 582 - 1.755 1.935 0.606
ENSG00000161647 E024 24.7217906 0.0007767235 2.253833e-03 8.011069e-03 17 43825623 43825755 133 - 1.248 1.465 0.752
ENSG00000161647 E025 35.6353312 0.0005967108 2.014677e-01 3.280062e-01 17 43825756 43825841 86 - 1.502 1.571 0.236
ENSG00000161647 E026 33.7916748 0.0006666685 3.413052e-01 4.852148e-01 17 43827751 43827832 82 - 1.497 1.548 0.173
ENSG00000161647 E027 43.1310262 0.0005823167 7.972974e-02 1.591361e-01 17 43829654 43829791 138 - 1.574 1.662 0.299
ENSG00000161647 E028 27.5858780 0.0008021709 7.397224e-02 1.498646e-01 17 43830027 43830107 81 - 1.362 1.477 0.396
ENSG00000161647 E029 24.9882013 0.0025891209 7.296775e-02 1.482749e-01 17 43831244 43831321 78 - 1.309 1.436 0.439
ENSG00000161647 E030 34.3592002 0.0011245643 9.728784e-01 9.870765e-01 17 43831559 43831677 119 - 1.532 1.523 -0.030
ENSG00000161647 E031 24.9171242 0.0009336502 4.199486e-01 5.632026e-01 17 43831882 43831943 62 - 1.435 1.373 -0.215
ENSG00000161647 E032 0.9180607 0.0141853387 2.889465e-01 4.296043e-01 17 43831944 43832076 133 - 0.140 0.326 1.555
ENSG00000161647 E033 1.3253775 0.0100170099 7.677097e-01 8.498869e-01 17 43832077 43832251 175 - 0.330 0.379 0.290
ENSG00000161647 E034 22.1285835 0.0009364160 4.658108e-01 6.054314e-01 17 43832761 43832819 59 - 1.383 1.324 -0.207
ENSG00000161647 E035 15.3465075 0.0012250648 2.335374e-01 3.666023e-01 17 43833101 43833170 70 - 1.258 1.149 -0.384