ENSG00000161642

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338010 ENSG00000161642 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF385A protein_coding protein_coding 7.979645 13.61437 4.619222 0.6492286 0.4422225 -1.557348 5.0055958 9.6068697 2.3148955 0.4238994 0.4562102 -2.0484015 0.58437083 0.70613333 0.49426667 -0.21186667 0.02774789 0.02774789 FALSE TRUE
ENST00000352268 ENSG00000161642 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF385A protein_coding protein_coding 7.979645 13.61437 4.619222 0.6492286 0.4422225 -1.557348 0.5046540 1.1823655 0.5548667 0.1644434 0.2484516 -1.0778442 0.05493750 0.08846667 0.12733333 0.03886667 0.88769776 0.02774789 FALSE TRUE
ENST00000551109 ENSG00000161642 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF385A protein_coding protein_coding 7.979645 13.61437 4.619222 0.6492286 0.4422225 -1.557348 0.5083714 0.3652021 0.3951681 0.2689436 0.3951681 0.1108528 0.09249167 0.02546667 0.09493333 0.06946667 0.88858147 0.02774789 FALSE TRUE
ENST00000552382 ENSG00000161642 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF385A protein_coding processed_transcript 7.979645 13.61437 4.619222 0.6492286 0.4422225 -1.557348 1.5123968 1.9398546 0.7972447 0.4704961 0.2535512 -1.2722885 0.19394583 0.14033333 0.16583333 0.02550000 0.86275817 0.02774789 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161642 E001 0.1482932 0.0417805105 1.00000000   12 54369133 54369134 2 - 0.000 0.071 8.513
ENSG00000161642 E002 0.1482932 0.0417805105 1.00000000   12 54369135 54369135 1 - 0.000 0.071 10.601
ENSG00000161642 E003 1.4778222 0.2476360771 0.53707357 0.66871928 12 54369136 54369139 4 - 0.204 0.375 1.198
ENSG00000161642 E004 5.3087793 0.0045533590 0.37538495 0.51981633 12 54369140 54369152 13 - 0.602 0.748 0.617
ENSG00000161642 E005 242.1053547 0.0048389687 0.10915618 0.20430105 12 54369153 54369877 725 - 2.229 2.298 0.233
ENSG00000161642 E006 85.4561350 0.0004768889 0.13969115 0.24759361 12 54369878 54370161 284 - 1.772 1.845 0.248
ENSG00000161642 E007 59.4986773 0.0004621784 0.25431117 0.39097029 12 54370162 54370486 325 - 1.621 1.688 0.230
ENSG00000161642 E008 61.9567611 0.0004490049 0.52037906 0.65434779 12 54370626 54370721 96 - 1.720 1.690 -0.104
ENSG00000161642 E009 70.8260740 0.0004376004 0.83338039 0.89561339 12 54370927 54371005 79 - 1.758 1.751 -0.024
ENSG00000161642 E010 43.5245227 0.0005770821 0.60410774 0.72474796 12 54371006 54371023 18 - 1.515 1.552 0.127
ENSG00000161642 E011 68.2130437 0.0003699299 0.14000141 0.24802311 12 54371024 54371096 73 - 1.793 1.724 -0.233
ENSG00000161642 E012 51.4495329 0.0005845936 0.27142723 0.41018725 12 54371473 54371490 18 - 1.668 1.609 -0.201
ENSG00000161642 E013 71.7983466 0.0027436776 0.84734056 0.90518730 12 54371491 54371582 92 - 1.767 1.760 -0.024
ENSG00000161642 E014 67.2553671 0.0101701340 0.98788025 0.99647495 12 54371583 54371641 59 - 1.730 1.733 0.012
ENSG00000161642 E015 39.6969468 0.0037542699 0.74813706 0.83546911 12 54371642 54371642 1 - 1.482 1.509 0.093
ENSG00000161642 E016 52.6798348 0.0004919588 0.55408473 0.68312512 12 54371643 54371683 41 - 1.595 1.633 0.129
ENSG00000161642 E017 47.5203812 0.0009812135 0.80272507 0.87435954 12 54371684 54371715 32 - 1.567 1.586 0.062
ENSG00000161642 E018 0.1472490 0.0426066867 0.13117736   12 54372894 54372913 20 - 0.204 0.000 -13.758
ENSG00000161642 E019 0.2924217 0.0274424043 0.02762275   12 54372914 54373031 118 - 0.342 0.000 -14.892
ENSG00000161642 E020 83.8798971 0.0003672482 0.01568708 0.04203553 12 54373973 54374135 163 - 1.903 1.801 -0.344
ENSG00000161642 E021 50.0862568 0.0059171251 0.06731973 0.13889698 12 54375844 54375954 111 - 1.695 1.581 -0.386
ENSG00000161642 E022 14.9810877 0.0147629728 0.18616526 0.30893606 12 54379066 54379189 124 - 1.219 1.074 -0.521
ENSG00000161642 E023 0.1515154 0.0457634123 0.13078224   12 54381298 54381447 150 - 0.204 0.000 -13.729
ENSG00000161642 E024 19.6245477 0.0011212475 0.99507527 1.00000000 12 54384428 54384560 133 - 1.219 1.223 0.014
ENSG00000161642 E025 10.1483797 0.0017435758 0.45591018 0.59638881 12 54384561 54384564 4 - 0.880 0.977 0.365
ENSG00000161642 E026 1.3127051 0.1586693471 0.40406852 0.54778430 12 54384565 54384699 135 - 0.446 0.275 -1.023
ENSG00000161642 E027 0.3268771 0.0279508539 0.37070481   12 54384700 54384733 34 - 0.204 0.071 -1.760
ENSG00000161642 E028 0.8072441 0.0168839775 0.90933490 0.94641788 12 54384859 54385002 144 - 0.204 0.232 0.237
ENSG00000161642 E029 0.0000000       12 54385235 54385264 30 -      
ENSG00000161642 E030 0.6976476 0.0542944422 0.24856428 0.38423367 12 54385673 54385768 96 - 0.342 0.132 -1.754
ENSG00000161642 E031 10.0513658 0.0017893875 0.09089231 0.17655544 12 54391235 54391298 64 - 0.763 0.993 0.883