ENSG00000161638

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000293379 ENSG00000161638 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGA5 protein_coding protein_coding 8.487216 9.712994 5.482057 0.6354313 0.1544501 -0.8240541 7.628206 9.40377 4.728902 0.5618815 0.01518482 -0.9902198 0.8984 0.9689 0.8640667 -0.1048333 0.002237174 0.002237174 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161638 E001 177.5826613 0.0015653869 1.319125e-11 2.694095e-10 12 54395261 54395894 634 - 2.025 2.265 0.801
ENSG00000161638 E002 144.7391627 0.0024193567 4.164291e-06 3.015374e-05 12 54395895 54396221 327 - 1.977 2.164 0.626
ENSG00000161638 E003 78.7874824 0.0004298666 2.002284e-02 5.153754e-02 12 54396222 54396376 155 - 1.778 1.881 0.348
ENSG00000161638 E004 0.1515154 0.0423280973 2.418842e-01   12 54397271 54397364 94 - 0.166 0.000 -12.716
ENSG00000161638 E005 32.2260487 0.0006113759 1.793034e-01 3.002365e-01 12 54397365 54397365 1 - 1.409 1.499 0.312
ENSG00000161638 E006 79.5874563 0.0005753787 5.542957e-02 1.187261e-01 12 54397366 54397487 122 - 1.798 1.883 0.286
ENSG00000161638 E007 65.6447162 0.0003950518 3.574439e-01 5.018578e-01 12 54398597 54398698 102 - 1.747 1.790 0.147
ENSG00000161638 E008 0.2214452 0.0376156673 1.000000e+00   12 54398699 54398823 125 - 0.000 0.089 10.450
ENSG00000161638 E009 61.3076615 0.0062907753 5.605890e-01 6.885720e-01 12 54399645 54399758 114 - 1.724 1.763 0.129
ENSG00000161638 E010 0.8846520 0.0135635346 1.181705e-02 3.309734e-02 12 54399759 54399863 105 - 0.521 0.089 -3.349
ENSG00000161638 E011 53.8765094 0.0005375765 1.857515e-01 3.084406e-01 12 54399864 54399947 84 - 1.645 1.715 0.236
ENSG00000161638 E012 8.6292554 0.0026062951 1.039583e-04 5.403181e-04 12 54399948 54400845 898 - 1.200 0.779 -1.567
ENSG00000161638 E013 75.3402757 0.0044658864 9.795767e-01 9.912814e-01 12 54400846 54400995 150 - 1.840 1.840 -0.001
ENSG00000161638 E014 69.4545682 0.0011370336 6.859584e-01 7.885579e-01 12 54401373 54401478 106 - 1.817 1.798 -0.062
ENSG00000161638 E015 0.5838113 0.4679614476 2.584465e-01 3.956998e-01 12 54401560 54401584 25 - 0.378 0.087 -2.637
ENSG00000161638 E016 71.7798420 0.0016342515 4.411150e-01 5.827609e-01 12 54401585 54401665 81 - 1.841 1.805 -0.120
ENSG00000161638 E017 0.8815290 0.1332723161 7.747487e-01 8.548271e-01 12 54401666 54401775 110 - 0.285 0.228 -0.424
ENSG00000161638 E018 64.3876401 0.0011055265 9.034015e-01 9.425264e-01 12 54401776 54401855 80 - 1.771 1.766 -0.019
ENSG00000161638 E019 64.0573452 0.0040790652 2.750230e-01 4.142697e-01 12 54402001 54402080 80 - 1.721 1.784 0.213
ENSG00000161638 E020 39.4614147 0.0010388738 7.762387e-01 8.559278e-01 12 54402081 54402093 13 - 1.549 1.566 0.059
ENSG00000161638 E021 0.1472490 0.0427683591 2.421300e-01   12 54402094 54402179 86 - 0.166 0.000 -12.714
ENSG00000161638 E022 77.2311081 0.0019968948 2.843991e-01 4.246414e-01 12 54402180 54402330 151 - 1.882 1.833 -0.165
ENSG00000161638 E023 54.6623086 0.0004333802 2.607910e-01 3.983879e-01 12 54402983 54403050 68 - 1.739 1.683 -0.191
ENSG00000161638 E024 0.5149242 0.2503014459 9.818632e-01 9.926728e-01 12 54403051 54403172 122 - 0.166 0.164 -0.021
ENSG00000161638 E025 68.7344286 0.0042921372 9.491775e-01 9.721477e-01 12 54403187 54403324 138 - 1.798 1.802 0.013
ENSG00000161638 E026 0.0000000       12 54403325 54403624 300 -      
ENSG00000161638 E027 30.1406880 0.0097059252 6.238279e-01 7.403021e-01 12 54403625 54403631 7 - 1.424 1.466 0.144
ENSG00000161638 E028 58.2066805 0.0086674889 8.975027e-01 9.385633e-01 12 54403632 54403779 148 - 1.736 1.727 -0.029
ENSG00000161638 E029 18.4303683 0.0023443721 2.100266e-01 3.385693e-01 12 54403911 54403915 5 - 1.312 1.206 -0.372
ENSG00000161638 E030 30.8124358 0.0008782048 5.306334e-01 6.632068e-01 12 54403916 54403966 51 - 1.481 1.439 -0.144
ENSG00000161638 E031 0.2998086 0.0283690713 6.030830e-01   12 54403967 54404144 178 - 0.166 0.089 -1.029
ENSG00000161638 E032 39.6450125 0.0005527182 2.403081e-01 3.744994e-01 12 54404145 54404246 102 - 1.612 1.544 -0.233
ENSG00000161638 E033 0.5149111 0.0217681645 1.000000e+00 1.000000e+00 12 54404247 54404429 183 - 0.166 0.163 -0.026
ENSG00000161638 E034 31.1036655 0.0006767698 4.046382e-01 5.483379e-01 12 54404430 54404475 46 - 1.500 1.446 -0.188
ENSG00000161638 E035 1.3275556 0.0101278135 9.179983e-02 1.779442e-01 12 54404476 54404702 227 - 0.521 0.227 -1.762
ENSG00000161638 E036 39.9895875 0.0005868982 9.174065e-01 9.518445e-01 12 54404703 54404770 68 - 1.560 1.566 0.021
ENSG00000161638 E037 43.4631126 0.0101804162 2.284692e-01 3.605879e-01 12 54404771 54404894 124 - 1.537 1.628 0.311
ENSG00000161638 E038 22.3510267 0.0008715244 8.328508e-01 8.952832e-01 12 54405166 54405193 28 - 1.312 1.328 0.057
ENSG00000161638 E039 53.2664997 0.0004989149 9.412581e-02 1.815839e-01 12 54405194 54405374 181 - 1.747 1.662 -0.286
ENSG00000161638 E040 34.9461092 0.0006647722 8.185381e-03 2.425425e-02 12 54405664 54405716 53 - 1.617 1.456 -0.550
ENSG00000161638 E041 40.5298582 0.0128026217 4.495453e-02 1.001152e-01 12 54405870 54405926 57 - 1.672 1.523 -0.508
ENSG00000161638 E042 0.7512344 0.2908779374 1.298973e-02 3.588673e-02 12 54405927 54406116 190 - 0.523 0.000 -14.175
ENSG00000161638 E043 33.7570129 0.0007803820 8.059777e-05 4.307669e-04 12 54407649 54407692 44 - 1.650 1.409 -0.825
ENSG00000161638 E044 29.2601410 0.0156124839 1.201755e-02 3.357252e-02 12 54407832 54407876 45 - 1.576 1.363 -0.733
ENSG00000161638 E045 46.5028395 0.0073980870 1.959813e-02 5.062320e-02 12 54408110 54408235 126 - 1.732 1.580 -0.516
ENSG00000161638 E046 36.1670963 0.0006136567 5.521562e-02 1.183628e-01 12 54408756 54408801 46 - 1.602 1.487 -0.396
ENSG00000161638 E047 32.3551561 0.0006786663 7.317585e-03 2.204386e-02 12 54408893 54408954 62 - 1.592 1.424 -0.576
ENSG00000161638 E048 41.6045119 0.0007069619 2.171362e-01 3.469355e-01 12 54409232 54409352 121 - 1.631 1.561 -0.241
ENSG00000161638 E049 38.8924198 0.0134773480 2.846773e-01 4.249299e-01 12 54409485 54409597 113 - 1.612 1.529 -0.283
ENSG00000161638 E050 25.8577780 0.0137259499 3.079138e-01 4.501481e-01 12 54411834 54411907 74 - 1.446 1.355 -0.316
ENSG00000161638 E051 20.7236317 0.0019568821 8.299324e-02 1.642344e-01 12 54411908 54411964 57 - 1.384 1.247 -0.479
ENSG00000161638 E052 0.0000000       12 54412311 54412516 206 -      
ENSG00000161638 E053 0.0000000       12 54413145 54413428 284 -      
ENSG00000161638 E054 29.3453525 0.0254139306 1.954326e-01 3.205035e-01 12 54418981 54419266 286 - 1.519 1.397 -0.420