ENSG00000161526

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000577292 ENSG00000161526 HEK293_OSMI2_2hA HEK293_TMG_2hB SAP30BP protein_coding retained_intron 58.06131 67.05164 52.42084 0.9208179 2.583195 -0.3550722 4.654231 4.307229 5.417389 0.3470002 0.4815873 0.33015259 0.08251667 0.06426667 0.1044667 0.04020000 0.091824049 0.0003374879 FALSE TRUE
ENST00000579877 ENSG00000161526 HEK293_OSMI2_2hA HEK293_TMG_2hB SAP30BP protein_coding nonsense_mediated_decay 58.06131 67.05164 52.42084 0.9208179 2.583195 -0.3550722 10.064533 10.301469 9.775422 1.6421964 3.0486774 -0.07554387 0.17059167 0.15333333 0.1820667 0.02873333 0.904602627 0.0003374879 FALSE FALSE
ENST00000584667 ENSG00000161526 HEK293_OSMI2_2hA HEK293_TMG_2hB SAP30BP protein_coding protein_coding 58.06131 67.05164 52.42084 0.9208179 2.583195 -0.3550722 27.605348 37.949131 22.287949 1.7232359 0.1261256 -0.76753594 0.46984167 0.56573333 0.4272000 -0.13853333 0.008277518 0.0003374879 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161526 E001 4.9767753 0.0104734062 1.268059e-02 3.515836e-02 17 75667251 75667337 87 + 0.942 0.614 -1.316
ENSG00000161526 E002 12.1002310 0.0013996133 8.376267e-04 3.393624e-03 17 75667338 75667345 8 + 1.268 0.969 -1.080
ENSG00000161526 E003 39.7781961 0.0052631457 5.065557e-03 1.610888e-02 17 75667346 75667350 5 + 1.688 1.519 -0.576
ENSG00000161526 E004 58.0376539 0.0031336703 1.695906e-03 6.270307e-03 17 75667351 75667355 5 + 1.840 1.687 -0.517
ENSG00000161526 E005 66.9267924 0.0004446042 2.419726e-03 8.521422e-03 17 75667356 75667361 6 + 1.881 1.764 -0.396
ENSG00000161526 E006 93.7974376 0.0003904118 4.371103e-03 1.417991e-02 17 75667362 75667365 4 + 2.011 1.920 -0.305
ENSG00000161526 E007 109.4354717 0.0004891571 8.256315e-06 5.590786e-05 17 75667366 75667369 4 + 2.107 1.967 -0.471
ENSG00000161526 E008 112.0173280 0.0004024454 8.971139e-06 6.030428e-05 17 75667370 75667370 1 + 2.115 1.979 -0.458
ENSG00000161526 E009 114.1700855 0.0003018439 4.196599e-06 3.037260e-05 17 75667371 75667373 3 + 2.125 1.986 -0.466
ENSG00000161526 E010 280.7242560 0.0006030129 2.530022e-02 6.249333e-02 17 75667374 75667425 52 + 2.452 2.413 -0.128
ENSG00000161526 E011 329.2032936 0.0006089750 4.712475e-03 1.513083e-02 17 75667426 75667478 53 + 2.528 2.479 -0.162
ENSG00000161526 E012 0.0000000       17 75668049 75668169 121 +      
ENSG00000161526 E013 496.0702361 0.0002951101 1.190845e-01 2.186398e-01 17 75668516 75668625 110 + 2.683 2.672 -0.037
ENSG00000161526 E014 315.3947174 0.0002038911 5.786352e-01 7.036937e-01 17 75671816 75671863 48 + 2.462 2.491 0.095
ENSG00000161526 E015 0.7468662 0.0465945588 3.295167e-01 4.730350e-01 17 75671864 75672156 293 + 0.347 0.181 -1.247
ENSG00000161526 E016 11.8044827 0.0014564656 1.143882e-01 2.119445e-01 17 75690671 75690772 102 + 1.173 1.036 -0.493
ENSG00000161526 E017 12.8689888 0.0014136129 9.395257e-02 1.813101e-01 17 75691394 75691531 138 + 1.207 1.066 -0.505
ENSG00000161526 E018 7.9954459 0.0062980142 7.827293e-02 1.566989e-01 17 75691532 75691569 38 + 1.049 0.859 -0.712
ENSG00000161526 E019 8.0245788 0.0233333696 4.041480e-02 9.178209e-02 17 75691570 75692043 474 + 1.080 0.828 -0.943
ENSG00000161526 E020 9.5776239 0.0034278138 2.424894e-05 1.475664e-04 17 75692044 75692527 484 + 1.239 0.809 -1.584
ENSG00000161526 E021 1.0726991 0.0117471417 7.618846e-02 1.534175e-01 17 75692528 75692545 18 + 0.483 0.181 -1.977
ENSG00000161526 E022 3.3130088 0.0048604677 3.231447e-05 1.906890e-04 17 75692546 75692687 142 + 0.921 0.309 -2.824
ENSG00000161526 E023 8.0798232 0.0035344123 1.918750e-01 3.161212e-01 17 75692688 75693439 752 + 1.033 0.903 -0.487
ENSG00000161526 E024 317.1661040 0.0001682344 5.793744e-01 7.042897e-01 17 75693440 75693482 43 + 2.464 2.492 0.094
ENSG00000161526 E025 402.9637779 0.0008746044 2.612606e-01 3.989022e-01 17 75699783 75699871 89 + 2.558 2.598 0.135
ENSG00000161526 E026 11.4289828 0.0021635177 2.531651e-02 6.252496e-02 17 75699872 75700259 388 + 1.196 0.992 -0.736
ENSG00000161526 E027 449.3060238 0.0003745647 4.622780e-02 1.024558e-01 17 75702480 75702571 92 + 2.597 2.651 0.181
ENSG00000161526 E028 52.8358997 0.0035426442 3.530352e-04 1.592037e-03 17 75702572 75702946 375 + 1.819 1.635 -0.624
ENSG00000161526 E029 54.2483962 0.0036581572 1.105642e-03 4.322017e-03 17 75702947 75703265 319 + 1.819 1.653 -0.562
ENSG00000161526 E030 18.6009055 0.0052433439 6.581758e-02 1.363993e-01 17 75703266 75703310 45 + 1.355 1.213 -0.497
ENSG00000161526 E031 378.1596551 0.0001704036 4.059985e-01 5.496533e-01 17 75703311 75703371 61 + 2.537 2.570 0.109
ENSG00000161526 E032 45.3505245 0.0133101191 7.638407e-03 2.286923e-02 17 75703372 75703705 334 + 1.759 1.567 -0.650
ENSG00000161526 E033 15.8997923 0.0011741572 4.714152e-02 1.040755e-01 17 75703770 75703807 38 + 1.305 1.153 -0.536
ENSG00000161526 E034 375.4295423 0.0004033399 8.197683e-01 8.862233e-01 17 75703808 75703859 52 + 2.542 2.564 0.072
ENSG00000161526 E035 10.5710269 0.0131483789 5.755040e-01 7.011010e-01 17 75704714 75704755 42 + 0.981 1.059 0.285
ENSG00000161526 E036 306.2162881 0.0015741922 3.536645e-01 4.979263e-01 17 75704756 75704771 16 + 2.473 2.464 -0.031
ENSG00000161526 E037 386.3276174 0.0006992874 7.550796e-02 1.523192e-01 17 75704772 75704814 43 + 2.531 2.587 0.188
ENSG00000161526 E038 62.3629190 0.0109173465 4.629073e-02 1.025605e-01 17 75704815 75705610 796 + 1.855 1.732 -0.416
ENSG00000161526 E039 13.6947672 0.0015243402 2.822326e-01 4.222056e-01 17 75705611 75705693 83 + 1.196 1.112 -0.299
ENSG00000161526 E040 31.7676280 0.0006544201 4.485635e-03 1.450129e-02 17 75705694 75706007 314 + 1.591 1.431 -0.549
ENSG00000161526 E041 437.4172178 0.0019274172 3.460483e-02 8.090961e-02 17 75706008 75706092 85 + 2.572 2.647 0.248
ENSG00000161526 E042 3.5888643 0.0056212061 4.776291e-01 6.161534e-01 17 75706093 75706184 92 + 0.706 0.614 -0.392
ENSG00000161526 E043 3.6942816 0.0046094004 7.782298e-01 8.573000e-01 17 75706185 75706229 45 + 0.670 0.641 -0.123
ENSG00000161526 E044 3.4631828 0.0055310861 3.783947e-01 5.226813e-01 17 75706230 75706339 110 + 0.538 0.689 0.667
ENSG00000161526 E045 1447.5626492 0.0011849343 5.118785e-11 9.496067e-10 17 75706340 75708062 1723 + 3.055 3.178 0.411