ENSG00000161513

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000293195 ENSG00000161513 HEK293_OSMI2_2hA HEK293_TMG_2hB FDXR protein_coding protein_coding 24.5913 46.26396 11.14246 1.737823 0.2682634 -2.052838 16.314417 34.2763322 6.8737477 0.1213311 0.7826738 -2.3163675 0.64154167 0.74283333 0.61430000 -0.12853333 2.486294e-01 1.467033e-08 FALSE  
ENST00000578473 ENSG00000161513 HEK293_OSMI2_2hA HEK293_TMG_2hB FDXR protein_coding retained_intron 24.5913 46.26396 11.14246 1.737823 0.2682634 -2.052838 1.227858 0.6388712 0.9493376 0.1042776 0.1655184 0.5641063 0.06917917 0.01383333 0.08456667 0.07073333 1.467033e-08 1.467033e-08 FALSE  
MSTRG.15042.12 ENSG00000161513 HEK293_OSMI2_2hA HEK293_TMG_2hB FDXR protein_coding   24.5913 46.26396 11.14246 1.737823 0.2682634 -2.052838 1.558545 2.7035439 0.8177390 1.3914051 0.4474840 -1.7129304 0.05580833 0.05626667 0.07483333 0.01856667 9.871451e-01 1.467033e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161513 E001 0.3697384 0.0274424043 1.000000e+00 1.000000e+00 17 74862497 74862497 1 - 0.001 0.114 7.788
ENSG00000161513 E002 1.0297335 0.0121989077 2.799044e-01 4.196982e-01 17 74862498 74862498 1 - 0.000 0.278 11.692
ENSG00000161513 E003 1.6960583 0.0112899599 1.032503e-01 1.954209e-01 17 74862499 74862500 2 - 0.000 0.397 12.401
ENSG00000161513 E004 3.6866146 0.0494426311 3.282936e-01 4.717858e-01 17 74862501 74862504 4 - 0.383 0.597 1.066
ENSG00000161513 E005 7.1143073 0.0522227040 2.451950e-01 3.802634e-01 17 74862505 74862517 13 - 0.583 0.819 0.987
ENSG00000161513 E006 39.3315747 0.0142594465 4.297710e-01 5.724367e-01 17 74862518 74862541 24 - 1.398 1.477 0.272
ENSG00000161513 E007 39.8432767 0.0158420793 4.012441e-01 5.449458e-01 17 74862542 74862543 2 - 1.398 1.483 0.293
ENSG00000161513 E008 56.5609483 0.0165021330 1.999335e-01 3.261671e-01 17 74862544 74862561 18 - 1.516 1.634 0.403
ENSG00000161513 E009 112.1420986 0.0305542977 3.336676e-01 4.774057e-01 17 74862562 74862608 47 - 1.837 1.920 0.280
ENSG00000161513 E010 367.4389511 0.0012593109 1.799401e-05 1.127770e-04 17 74862609 74862947 339 - 2.301 2.438 0.455
ENSG00000161513 E011 328.7246190 0.0014192467 2.225275e-04 1.060024e-03 17 74863076 74863246 171 - 2.261 2.387 0.419
ENSG00000161513 E012 301.2033763 0.0012518473 3.676716e-03 1.222992e-02 17 74863896 74864067 172 - 2.246 2.346 0.334
ENSG00000161513 E013 4.8026667 0.0418761368 3.213184e-02 7.611363e-02 17 74864068 74864147 80 - 0.907 0.555 -1.449
ENSG00000161513 E014 208.3111820 0.0005283924 2.184520e-03 7.794092e-03 17 74864148 74864275 128 - 2.070 2.185 0.384
ENSG00000161513 E015 179.6868897 0.0002146353 4.181493e-04 1.843931e-03 17 74864276 74864345 70 - 1.987 2.126 0.464
ENSG00000161513 E016 103.2780539 0.0002987850 1.210014e-01 2.213662e-01 17 74864346 74864347 2 - 1.801 1.880 0.267
ENSG00000161513 E017 185.9442921 0.0001968530 7.506757e-01 8.372775e-01 17 74864480 74864564 85 - 2.110 2.125 0.050
ENSG00000161513 E018 213.7459860 0.0002482911 8.211160e-01 8.872347e-01 17 74864824 74864895 72 - 2.188 2.185 -0.011
ENSG00000161513 E019 192.9869075 0.0002504898 6.098227e-02 1.282872e-01 17 74864896 74864931 36 - 2.190 2.132 -0.195
ENSG00000161513 E020 4.2330666 0.0039359796 3.357898e-03 1.131485e-02 17 74864932 74864949 18 - 0.943 0.512 -1.790
ENSG00000161513 E021 242.8827977 0.0001928210 4.615579e-02 1.023225e-01 17 74865719 74865820 102 - 2.286 2.231 -0.183
ENSG00000161513 E022 113.0973211 0.0003059796 5.970662e-01 7.188952e-01 17 74866131 74866136 6 - 1.884 1.912 0.094
ENSG00000161513 E023 154.0300646 0.0002761603 6.283888e-01 7.439282e-01 17 74866137 74866180 44 - 2.021 2.043 0.076
ENSG00000161513 E024 129.4541180 0.0002855991 1.498905e-01 2.615364e-01 17 74866181 74866208 28 - 1.908 1.974 0.222
ENSG00000161513 E025 177.1242379 0.0027017190 9.886986e-01 9.969716e-01 17 74866209 74866244 36 - 2.096 2.100 0.016
ENSG00000161513 E026 217.3798682 0.0019766048 7.682188e-02 1.544107e-01 17 74866446 74866511 66 - 2.239 2.179 -0.202
ENSG00000161513 E027 165.7001723 0.0002651122 3.801691e-03 1.258618e-02 17 74866512 74866544 33 - 2.153 2.055 -0.329
ENSG00000161513 E028 142.2234360 0.0002359843 1.277993e-03 4.904024e-03 17 74866545 74866568 24 - 2.105 1.989 -0.392
ENSG00000161513 E029 4.5822959 0.0203861606 5.445744e-05 3.040254e-04 17 74866569 74866783 215 - 1.065 0.470 -2.443
ENSG00000161513 E030 270.5637611 0.0005052197 3.166224e-02 7.519319e-02 17 74866784 74866876 93 - 2.333 2.274 -0.196
ENSG00000161513 E031 32.6523045 0.0115343764 4.199467e-01 5.632026e-01 17 74866877 74866879 3 - 1.434 1.365 -0.237
ENSG00000161513 E032 2.7499564 0.1293497709 2.631589e-01 4.010222e-01 17 74866880 74866898 19 - 0.656 0.426 -1.085
ENSG00000161513 E033 3.0957468 0.0079891380 6.043247e-01 7.249118e-01 17 74866899 74867005 107 - 0.583 0.491 -0.430
ENSG00000161513 E034 2.6274971 0.2621048701 9.010029e-01 9.408538e-01 17 74868230 74868544 315 - 0.382 0.471 0.475
ENSG00000161513 E035 1.7242607 0.0082363583 3.339350e-01 4.776908e-01 17 74868545 74868753 209 - 0.494 0.312 -1.014
ENSG00000161513 E036 2.2307789 0.1824523175 2.920634e-01 4.330030e-01 17 74869950 74870102 153 - 0.582 0.374 -1.050
ENSG00000161513 E037 201.6126935 0.0003445427 1.918200e-01 3.160416e-01 17 74872036 74872107 72 - 2.190 2.151 -0.132
ENSG00000161513 E038 95.4467258 0.0030474605 1.605744e-01 2.758988e-01 17 74872108 74872133 26 - 1.896 1.826 -0.237
ENSG00000161513 E039 5.0812131 0.0172636645 1.792443e-05 1.123818e-04 17 74872198 74872242 45 - 1.114 0.511 -2.422
ENSG00000161513 E040 7.1136633 0.0023976731 2.115607e-07 2.018205e-06 17 74872243 74872316 74 - 1.237 0.618 -2.368
ENSG00000161513 E041 7.9597694 0.0215918957 5.490626e-10 8.546402e-09 17 74872317 74872377 61 - 1.360 0.570 -3.013
ENSG00000161513 E042 13.3106712 0.0026323155 3.773284e-12 8.422732e-11 17 74872378 74872686 309 - 1.487 0.826 -2.379
ENSG00000161513 E043 4.5069407 0.0036418081 1.848756e-05 1.156103e-04 17 74872687 74872754 68 - 1.064 0.470 -2.444
ENSG00000161513 E044 2.5454143 0.0058293487 7.641724e-06 5.213749e-05 17 74872755 74872768 14 - 0.943 0.243 -3.374
ENSG00000161513 E045 8.8005741 0.0018973954 1.842058e-07 1.777569e-06 17 74872769 74872865 97 - 1.287 0.703 -2.182
ENSG00000161513 E046 149.5995931 0.0005728879 4.282853e-01 5.710842e-01 17 74872866 74873031 166 - 2.052 2.024 -0.092