ENSG00000161267

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392378 ENSG00000161267 HEK293_OSMI2_2hA HEK293_TMG_2hB BDH1 protein_coding protein_coding 7.054281 16.30687 1.888413 0.26854 0.09337797 -3.103498 1.23774933 2.660644 0.4324718 0.1292578 0.10551331 -2.593530 0.1765208 0.1630667 0.2329333 0.069866667 5.613283e-01 3.701662e-06 FALSE TRUE
ENST00000431056 ENSG00000161267 HEK293_OSMI2_2hA HEK293_TMG_2hB BDH1 protein_coding protein_coding 7.054281 16.30687 1.888413 0.26854 0.09337797 -3.103498 0.07367254 0.000000 0.1069532 0.0000000 0.10695318 3.547859 0.0319750 0.0000000 0.0601000 0.060100000 4.383219e-01 3.701662e-06   FALSE
ENST00000432819 ENSG00000161267 HEK293_OSMI2_2hA HEK293_TMG_2hB BDH1 protein_coding protein_coding 7.054281 16.30687 1.888413 0.26854 0.09337797 -3.103498 0.85036123 2.424190 0.3097815 0.4010818 0.19440064 -2.928283 0.1120458 0.1480000 0.1554333 0.007433333 9.051458e-01 3.701662e-06 FALSE FALSE
ENST00000441275 ENSG00000161267 HEK293_OSMI2_2hA HEK293_TMG_2hB BDH1 protein_coding protein_coding 7.054281 16.30687 1.888413 0.26854 0.09337797 -3.103498 3.17814480 7.812141 0.8650610 0.1067072 0.09480725 -3.160108 0.4285000 0.4791667 0.4581333 -0.021033333 9.204641e-01 3.701662e-06 FALSE TRUE
ENST00000446746 ENSG00000161267 HEK293_OSMI2_2hA HEK293_TMG_2hB BDH1 protein_coding protein_coding 7.054281 16.30687 1.888413 0.26854 0.09337797 -3.103498 0.95762774 2.442424 0.0000000 0.4172361 0.00000000 -7.938065 0.1054708 0.1506333 0.0000000 -0.150633333 3.701662e-06 3.701662e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161267 E001 37.3088370 0.0006402599 0.14415399 0.25365763 3 197509783 197511467 1685 - 1.450 1.320 -0.451
ENSG00000161267 E002 9.4948744 0.0231300422 0.12657792 0.22938184 3 197511468 197511593 126 - 1.002 0.754 -0.954
ENSG00000161267 E003 132.1012218 0.0002521449 0.58403154 0.70802925 3 197511594 197511994 401 - 1.889 1.861 -0.096
ENSG00000161267 E004 113.2596837 0.0003149336 0.97665962 0.98941859 3 197511995 197512167 173 - 1.795 1.795 -0.001
ENSG00000161267 E005 65.2646971 0.0017238920 0.85773225 0.91213676 3 197512168 197512221 54 - 1.547 1.558 0.037
ENSG00000161267 E006 73.8111181 0.0007908643 0.24705407 0.38247027 3 197512222 197512327 106 - 1.534 1.617 0.283
ENSG00000161267 E007 42.1840078 0.0005709617 0.64394512 0.75637979 3 197512328 197512364 37 - 1.345 1.386 0.144
ENSG00000161267 E008 0.0000000       3 197514153 197514262 110 -      
ENSG00000161267 E009 0.0000000       3 197514263 197514263 1 -      
ENSG00000161267 E010 30.3455757 0.0008294320 0.48781060 0.62544755 3 197514264 197514265 2 - 1.179 1.254 0.265
ENSG00000161267 E011 104.7857795 0.0009920789 0.65126862 0.76218980 3 197514266 197514416 151 - 1.743 1.769 0.087
ENSG00000161267 E012 1.2511787 0.0107178384 0.58903507 0.71215826 3 197515357 197515861 505 - 0.000 0.240 11.677
ENSG00000161267 E013 108.4067984 0.0002931775 0.39313674 0.53703024 3 197522640 197522781 142 - 1.735 1.783 0.161
ENSG00000161267 E014 0.7749789 0.0149652262 0.06837559 0.14068172 3 197522782 197523260 479 - 0.479 0.119 -2.675
ENSG00000161267 E015 2.2455014 0.0098392603 0.03437590 0.08047663 3 197524835 197527251 2417 - 0.701 0.290 -2.086
ENSG00000161267 E016 0.5180316 0.0215541614 1.00000000 1.00000000 3 197527887 197527987 101 - 0.000 0.119 10.471
ENSG00000161267 E017 1.5352962 0.2833602305 0.03651686 0.08456272 3 197528310 197529882 1573 - 0.700 0.187 -2.899
ENSG00000161267 E018 1.8339458 0.0078739644 0.01681648 0.04452843 3 197529883 197530101 219 - 0.701 0.240 -2.450
ENSG00000161267 E019 3.2753472 0.0052550823 0.82316064 0.88854185 3 197530102 197530690 589 - 0.479 0.429 -0.256
ENSG00000161267 E020 1.5457760 0.0178067875 0.48560282 0.62347342 3 197530691 197530744 54 - 0.000 0.266 11.815
ENSG00000161267 E021 67.5313274 0.0003878302 0.31558350 0.45834718 3 197532412 197532514 103 - 1.508 1.581 0.252
ENSG00000161267 E022 34.4533683 0.0006699459 0.69953281 0.79922078 3 197532515 197532522 8 - 1.258 1.295 0.131
ENSG00000161267 E023 0.0000000       3 197533485 197533488 4 -      
ENSG00000161267 E024 33.4759463 0.0006866932 0.44545801 0.58699213 3 197533489 197533492 4 - 1.207 1.286 0.279
ENSG00000161267 E025 59.2951876 0.0004145830 0.88132577 0.92794155 3 197533493 197533561 69 - 1.534 1.521 -0.045
ENSG00000161267 E026 3.1143947 0.1257865835 0.76331528 0.84666469 3 197533562 197534156 595 - 0.479 0.417 -0.320
ENSG00000161267 E027 2.0855044 0.1243706046 0.96980886 0.98510699 3 197538306 197538666 361 - 0.302 0.333 0.199
ENSG00000161267 E028 1.0997650 0.0123096151 0.57121989 0.69755501 3 197538667 197538952 286 - 0.302 0.184 -0.933
ENSG00000161267 E029 0.1817044 0.0405652043 0.60467298   3 197546119 197546360 242 - 0.000 0.043 8.831
ENSG00000161267 E030 52.0247043 0.0071317346 0.52436665 0.65790135 3 197546361 197546486 126 - 1.521 1.465 -0.191
ENSG00000161267 E031 1.5112334 0.0116157539 0.87808967 0.92571246 3 197554369 197554561 193 - 0.302 0.265 -0.259
ENSG00000161267 E032 8.3938893 0.0020711016 0.26308467 0.40094171 3 197554562 197554713 152 - 0.905 0.725 -0.707
ENSG00000161267 E033 0.1482932 0.0415177584 0.60108941   3 197555342 197555507 166 - 0.000 0.043 8.823
ENSG00000161267 E034 0.0000000       3 197555508 197555780 273 -      
ENSG00000161267 E035 44.3258021 0.0071541761 0.99980850 1.00000000 3 197555781 197556048 268 - 1.401 1.399 -0.005
ENSG00000161267 E036 0.1515154 0.0480264358 0.03060023   3 197573181 197573323 143 - 0.302 0.000 -13.763