ENSG00000161204

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000292808 ENSG00000161204 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCF3 protein_coding protein_coding 36.2014 45.71391 25.91952 0.5552864 0.9858804 -0.8183534 2.033453 4.067573 0.7823846 0.5200726 0.7823846 -2.3634381 0.05420000 0.08916667 0.03190000 -0.05726667 0.156104076 4.740514e-08 FALSE TRUE
ENST00000429586 ENSG00000161204 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCF3 protein_coding protein_coding 36.2014 45.71391 25.91952 0.5552864 0.9858804 -0.8183534 18.395412 31.518172 9.7831031 1.6355963 1.4663684 -1.6868035 0.48333333 0.68896667 0.38033333 -0.30863333 0.002023116 4.740514e-08 FALSE TRUE
ENST00000478288 ENSG00000161204 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCF3 protein_coding retained_intron 36.2014 45.71391 25.91952 0.5552864 0.9858804 -0.8183534 2.483264 1.264032 2.1114712 0.4200584 0.2087669 0.7356634 0.07360417 0.02763333 0.08113333 0.05350000 0.022528822 4.740514e-08 TRUE TRUE
MSTRG.24187.9 ENSG00000161204 HEK293_OSMI2_2hA HEK293_TMG_2hB ABCF3 protein_coding   36.2014 45.71391 25.91952 0.5552864 0.9858804 -0.8183534 1.771129 0.000000 1.9839177 0.0000000 1.3418030 7.6394620 0.05734167 0.00000000 0.07356667 0.07356667 0.147840106 4.740514e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161204 E001 0.1817044 0.0397129522 1.000000e+00   3 184186095 184186103 9 + 0.000 0.079 7.549
ENSG00000161204 E002 1.2533568 0.0105483678 9.400632e-01 9.663534e-01 3 184186104 184186159 56 + 0.316 0.299 -0.109
ENSG00000161204 E003 1.2533568 0.0105483678 9.400632e-01 9.663534e-01 3 184186160 184186160 1 + 0.316 0.299 -0.109
ENSG00000161204 E004 4.8485889 0.0351570401 4.588117e-01 5.990849e-01 3 184186161 184186173 13 + 0.803 0.677 -0.513
ENSG00000161204 E005 6.5092494 0.0062791702 2.521660e-01 3.884890e-01 3 184186174 184186175 2 + 0.929 0.774 -0.597
ENSG00000161204 E006 12.9316078 0.0018873669 1.455324e-03 5.490964e-03 3 184186176 184186190 15 + 1.295 0.987 -1.103
ENSG00000161204 E007 21.2307864 0.0019136126 1.876862e-05 1.171513e-04 3 184186191 184186195 5 + 1.513 1.178 -1.167
ENSG00000161204 E008 33.8265172 0.0007201479 1.550783e-02 4.164655e-02 3 184186196 184186198 3 + 1.591 1.430 -0.549
ENSG00000161204 E009 140.1393238 0.0051297848 4.314025e-02 9.680304e-02 3 184186199 184186280 82 + 2.153 2.052 -0.340
ENSG00000161204 E010 223.5511826 0.0002128629 2.284897e-02 5.742540e-02 3 184186507 184186636 130 + 2.328 2.263 -0.218
ENSG00000161204 E011 113.5218064 0.0002978066 7.829578e-01 8.606367e-01 3 184186637 184186654 18 + 1.981 1.986 0.019
ENSG00000161204 E012 4.5178445 0.0049226202 7.415685e-11 1.336199e-09 3 184186655 184186795 141 + 1.157 0.254 -4.075
ENSG00000161204 E013 194.4274556 0.0002509798 1.202548e-02 3.359174e-02 3 184186796 184186875 80 + 2.274 2.198 -0.256
ENSG00000161204 E014 13.5889226 0.0013273253 1.862941e-17 8.818805e-16 3 184186876 184187283 408 + 1.533 0.760 -2.801
ENSG00000161204 E015 7.0956102 0.0199140579 6.794891e-09 8.645210e-08 3 184187364 184187396 33 + 1.271 0.505 -3.006
ENSG00000161204 E016 163.1535079 0.0002233807 1.313654e-02 3.622256e-02 3 184187397 184187443 47 + 2.204 2.122 -0.272
ENSG00000161204 E017 19.3554253 0.0386365114 7.067278e-08 7.386895e-07 3 184187444 184187663 220 + 1.631 0.973 -2.313
ENSG00000161204 E018 203.1305843 0.0025911955 6.991226e-02 1.432355e-01 3 184187664 184187761 98 + 2.290 2.219 -0.237
ENSG00000161204 E019 6.2032806 0.0027231911 2.336434e-06 1.791156e-05 3 184187762 184187860 99 + 1.157 0.577 -2.269
ENSG00000161204 E020 188.8244244 0.0025260203 4.936267e-01 6.306213e-01 3 184187861 184187983 123 + 2.228 2.197 -0.102
ENSG00000161204 E021 222.1864447 0.0004091265 2.376881e-01 3.714704e-01 3 184188141 184188313 173 + 2.253 2.282 0.096
ENSG00000161204 E022 108.5805258 0.0005890471 9.176546e-01 9.519651e-01 3 184188314 184188333 20 + 1.976 1.967 -0.029
ENSG00000161204 E023 153.9861385 0.0002533039 2.832853e-01 4.233692e-01 3 184188334 184188407 74 + 2.095 2.126 0.104
ENSG00000161204 E024 1.5617008 0.1152325345 1.894452e-02 4.921046e-02 3 184188664 184188670 7 + 0.677 0.202 -2.664
ENSG00000161204 E025 100.5497693 0.0003101970 1.339385e-01 2.396216e-01 3 184188761 184188789 29 + 1.889 1.946 0.193
ENSG00000161204 E026 95.1393089 0.0003264258 1.065593e-01 2.004801e-01 3 184188790 184188808 19 + 1.861 1.925 0.216
ENSG00000161204 E027 111.3728969 0.0020353283 1.596683e-01 2.746771e-01 3 184188809 184188841 33 + 1.935 1.993 0.195
ENSG00000161204 E028 117.3793107 0.0002514675 9.598564e-02 1.843528e-01 3 184188929 184188988 60 + 1.956 2.015 0.198
ENSG00000161204 E029 123.8710342 0.0027701538 3.532620e-01 4.974919e-01 3 184189088 184189144 57 + 1.995 2.031 0.121
ENSG00000161204 E030 7.5587689 0.0021975011 8.617514e-03 2.533107e-02 3 184189145 184189254 110 + 1.087 0.775 -1.181
ENSG00000161204 E031 98.6116594 0.0003459143 8.915102e-01 9.347218e-01 3 184189255 184189277 23 + 1.926 1.927 0.003
ENSG00000161204 E032 8.4658381 0.0020195502 7.188453e-09 9.094029e-08 3 184189278 184189387 110 + 1.295 0.660 -2.392
ENSG00000161204 E033 144.5633435 0.0007812199 8.320053e-01 8.947158e-01 3 184189388 184189443 56 + 2.103 2.091 -0.039
ENSG00000161204 E034 7.6682869 0.0488875140 9.413820e-08 9.605838e-07 3 184189444 184189556 113 + 1.319 0.507 -3.163
ENSG00000161204 E035 186.8588436 0.0002106211 8.853580e-01 9.306762e-01 3 184189557 184189632 76 + 2.208 2.199 -0.030
ENSG00000161204 E036 252.0388953 0.0002115420 4.888349e-01 6.263539e-01 3 184189633 184189757 125 + 2.320 2.333 0.044
ENSG00000161204 E037 0.6234634 0.0182460162 9.422645e-01 9.677379e-01 3 184189830 184189854 25 + 0.186 0.202 0.150
ENSG00000161204 E038 190.9456412 0.0002338754 1.069335e-02 3.043730e-02 3 184189855 184189931 77 + 2.156 2.229 0.243
ENSG00000161204 E039 23.7985704 0.0007727045 4.512938e-26 5.414582e-24 3 184189932 184190863 932 + 1.757 1.013 -2.592
ENSG00000161204 E040 7.2352078 0.0022589403 2.421155e-08 2.777357e-07 3 184190864 184190998 135 + 1.245 0.599 -2.480
ENSG00000161204 E041 162.2037816 0.0002483168 2.691002e-01 4.075647e-01 3 184190999 184191043 45 + 2.119 2.150 0.104
ENSG00000161204 E042 247.4635179 0.0002361502 1.543703e-01 2.675883e-01 3 184191123 184191255 133 + 2.300 2.333 0.110
ENSG00000161204 E043 239.5995373 0.0003924523 6.917002e-03 2.100985e-02 3 184192601 184192689 89 + 2.257 2.327 0.236
ENSG00000161204 E044 8.6774498 0.0020206483 5.696206e-03 1.780682e-02 3 184192690 184192804 115 + 1.141 0.829 -1.160
ENSG00000161204 E045 227.2010520 0.0001950206 4.920306e-03 1.570788e-02 3 184192805 184192896 92 + 2.230 2.304 0.245
ENSG00000161204 E046 189.8462839 0.0002092979 7.530503e-02 1.520118e-01 3 184193102 184193149 48 + 2.170 2.219 0.163
ENSG00000161204 E047 238.9191320 0.0001901668 3.764138e-03 1.247996e-02 3 184193150 184193234 85 + 2.252 2.325 0.246
ENSG00000161204 E048 4.3427372 0.0036562240 2.210714e-01 3.516927e-01 3 184193235 184193364 130 + 0.803 0.620 -0.754
ENSG00000161204 E049 285.4342826 0.0023010571 7.593229e-02 1.530058e-01 3 184193365 184193452 88 + 2.344 2.398 0.181
ENSG00000161204 E050 443.7750499 0.0001583176 5.706251e-07 4.993681e-06 3 184193540 184193880 341 + 2.502 2.598 0.317
ENSG00000161204 E051 76.1509286 0.0004566425 4.627838e-03 1.489644e-02 3 184193881 184194012 132 + 1.714 1.848 0.452
ENSG00000161204 E052 6.4967529 0.0029920893 5.319796e-02 1.148473e-01 3 184195780 184195832 53 + 0.980 0.729 -0.972