ENSG00000161202

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313143 ENSG00000161202 HEK293_OSMI2_2hA HEK293_TMG_2hB DVL3 protein_coding protein_coding 29.25921 36.16224 24.31747 2.420968 1.167338 -0.572297 13.179465 15.980447 12.1974399 1.31116973 0.5138391 -0.3894496 0.45440417 0.4409333 0.5033 0.06236667 0.34838943 0.014806 FALSE TRUE
ENST00000478247 ENSG00000161202 HEK293_OSMI2_2hA HEK293_TMG_2hB DVL3 protein_coding retained_intron 29.25921 36.16224 24.31747 2.420968 1.167338 -0.572297 2.616292 1.897563 2.9321311 0.36326720 0.6730525 0.6251308 0.09440417 0.0519000 0.1209 0.06900000 0.05524227 0.014806 FALSE TRUE
ENST00000649847 ENSG00000161202 HEK293_OSMI2_2hA HEK293_TMG_2hB DVL3 protein_coding nonsense_mediated_decay 29.25921 36.16224 24.31747 2.420968 1.167338 -0.572297 1.915179 5.517371 0.2403531 0.06853332 0.2403531 -4.4645573 0.05436667 0.1537667 0.0091 -0.14466667 0.01480600 0.014806 FALSE TRUE
MSTRG.24184.1 ENSG00000161202 HEK293_OSMI2_2hA HEK293_TMG_2hB DVL3 protein_coding   29.25921 36.16224 24.31747 2.420968 1.167338 -0.572297 9.405949 11.769557 7.1110363 0.66206621 0.1220659 -0.7261261 0.31732083 0.3261000 0.2941 -0.03200000 0.58090737 0.014806 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000161202 E001 6.9571756 0.0050490357 3.455538e-01 4.896637e-01 3 184155349 184155376 28 + 0.939 0.831 -0.415
ENSG00000161202 E002 32.7788800 0.0146433531 2.262144e-11 4.448837e-10 3 184155377 184155558 182 + 1.781 1.226 -1.909
ENSG00000161202 E003 11.1826632 0.0015844786 2.552003e-21 1.897446e-19 3 184155559 184155561 3 + 1.455 0.410 -4.131
ENSG00000161202 E004 11.4448959 0.0015237882 2.392602e-23 2.195018e-21 3 184155562 184155564 3 + 1.473 0.363 -4.456
ENSG00000161202 E005 12.0413781 0.0013524005 5.418718e-22 4.313277e-20 3 184155565 184155568 4 + 1.479 0.452 -3.991
ENSG00000161202 E006 148.8965157 0.0068950271 2.037282e-04 9.798845e-04 3 184155569 184155796 228 + 2.254 2.085 -0.565
ENSG00000161202 E007 0.7727888 0.0952799234 9.586417e-01 9.780902e-01 3 184156360 184156447 88 + 0.257 0.250 -0.057
ENSG00000161202 E008 0.9610237 0.3374311569 8.784178e-01 9.259187e-01 3 184156775 184157067 293 + 0.258 0.263 0.037
ENSG00000161202 E009 0.9953799 0.0122048636 5.846296e-01 7.085049e-01 3 184162605 184162801 197 + 0.345 0.252 -0.628
ENSG00000161202 E010 125.2453181 0.0038015372 9.977188e-02 1.901347e-01 3 184163657 184163676 20 + 2.114 2.054 -0.201
ENSG00000161202 E011 170.5236443 0.0037533551 6.119060e-01 7.309466e-01 3 184163677 184163726 50 + 2.215 2.207 -0.026
ENSG00000161202 E012 242.7895762 0.0027120220 8.037984e-01 8.751663e-01 3 184164267 184164388 122 + 2.360 2.364 0.013
ENSG00000161202 E013 2.6688276 0.0076522840 1.688778e-01 2.867202e-01 3 184164478 184164491 14 + 0.667 0.452 -0.990
ENSG00000161202 E014 229.1582435 0.0011942442 3.949175e-01 5.387518e-01 3 184164492 184164601 110 + 2.346 2.332 -0.049
ENSG00000161202 E015 1.7274724 0.0084872384 2.484648e-02 6.155769e-02 3 184164647 184164795 149 + 0.627 0.252 -2.043
ENSG00000161202 E016 187.3837156 0.0015438896 6.349187e-02 1.325131e-01 3 184164796 184164855 60 + 2.283 2.234 -0.166
ENSG00000161202 E017 159.4079726 0.0033848599 2.226538e-01 3.535568e-01 3 184164856 184164929 74 + 2.207 2.168 -0.128
ENSG00000161202 E018 100.1274190 0.0045374659 2.419589e-01 3.765021e-01 3 184164930 184164931 2 + 2.011 1.964 -0.158
ENSG00000161202 E019 27.2181543 0.0007078652 4.558958e-08 4.957131e-07 3 184164932 184165112 181 + 1.622 1.268 -1.221
ENSG00000161202 E020 211.0454050 0.0039527869 1.693200e-01 2.873012e-01 3 184165113 184165206 94 + 2.330 2.289 -0.138
ENSG00000161202 E021 196.5655918 0.0031855444 1.421049e-01 2.508979e-01 3 184165422 184165491 70 + 2.301 2.258 -0.144
ENSG00000161202 E022 188.7964151 0.0006001386 7.593827e-03 2.275626e-02 3 184166126 184166193 68 + 2.297 2.230 -0.224
ENSG00000161202 E023 191.2312648 0.0002186013 8.036664e-01 8.750578e-01 3 184166194 184166265 72 + 2.257 2.258 0.004
ENSG00000161202 E024 206.3855550 0.0002908853 4.997459e-01 6.360198e-01 3 184166446 184166522 77 + 2.296 2.286 -0.032
ENSG00000161202 E025 3.2202835 0.1033086230 6.072404e-01 7.272673e-01 3 184166523 184166605 83 + 0.668 0.562 -0.464
ENSG00000161202 E026 216.4755069 0.0002170086 9.514220e-01 9.736133e-01 3 184166606 184166673 68 + 2.306 2.315 0.032
ENSG00000161202 E027 0.4502799 0.0270846873 3.497462e-02 8.160500e-02 3 184166674 184166701 28 + 0.345 0.000 -10.526
ENSG00000161202 E028 208.8849414 0.0010374321 2.494308e-01 3.852495e-01 3 184166826 184166876 51 + 2.270 2.313 0.142
ENSG00000161202 E029 303.5883381 0.0001919007 3.847699e-02 8.824238e-02 3 184166877 184166975 99 + 2.424 2.477 0.176
ENSG00000161202 E030 367.7690384 0.0002133399 3.078118e-01 4.500476e-01 3 184167580 184167711 132 + 2.525 2.553 0.094
ENSG00000161202 E031 423.6365878 0.0019018724 1.204923e-02 3.365112e-02 3 184167898 184168065 168 + 2.553 2.631 0.258
ENSG00000161202 E032 417.5380524 0.0020209561 2.085991e-04 1.000796e-03 3 184170006 184170221 216 + 2.522 2.635 0.376
ENSG00000161202 E033 363.0800385 0.0011571647 1.046461e-13 2.965577e-12 3 184170319 184170729 411 + 2.398 2.597 0.666
ENSG00000161202 E034 381.2457727 0.0001372853 5.711075e-05 3.171229e-04 3 184170730 184171566 837 + 2.600 2.533 -0.224
ENSG00000161202 E035 1429.5492488 0.0043366897 1.411337e-01 2.495972e-01 3 184171567 184173614 2048 + 3.099 3.152 0.173